Dietary calcium intake in patients with inflammatory bowel disease

Vernia, Piero; Loizos, P; Giuseppantonio, I. Di; Amore, B; Chiappini, A; Cannizzaro, S.

doi:10.1016/j.crohns.2013.09.008

Cited by 58 publications

(52 citation statements)

References 45 publications

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“…Patients with gut disorders are unable to retain calcium properly, and they need dietary supplements to increase its levels. Down-regulation of omega-9 MUFA is thus consistent with the onset of the disease [44].…”

Section: Anemia a Common Systemic Complication And/or Extra-intestinmentioning

confidence: 77%

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

Manfredi

Conte

Barberis

et al. 2019

Journal of Proteomics

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Inflammatory bowel disease (IBD) is a chronic inflammatory condition of unknown etiology that can develop in any portion of the digestive tract but which has a high incidence especially in the terminal ileum and/or in the colon. The diagnosis and management of IBD, including Crohn's disease (CD) and ulcerative colitis (UC), is still challenging, and the presence of intestinal inflammation is, to date, a primary criterion for its diagnosis and differentiation from other diseases. Moreover, there is no decisive gold standard diagnostic test based on patient history and physical examination, supplemented with objective laboratory, radiological, endoscopic and histological findings.This study analyzed plasma proteins and fatty acids using mass spectrometry-based techniques. Quantitation of low-abundance plasma proteins was performed by depleting 14 high-abundance proteins, followed by tryptic digestion and LC-MS analysis, while fatty acids were analyzed using GC-MS.We used bioinformatic tools to identify several new potential biomarkers for an early and non-invasive diagnosis of IBD, and to differentiate CD from UC. Moreover, the diagnostic power of the MS-identified biomarkers was also corroborated by Western Blot and ELISA assays. Hence, we identified the biological functions and pathways involved in the various subsets of IBD.Coagulation, fibrinolysis and acute phase response processes were found to be strongly involved in the condition. The involvement of several fatty acids, such as anti-inflammatory mediators, was also identified. Finally, proteomic and lipidomic data were integrated by using combinatorial and multivariate analyses to discover new combined biomarkers and to study the molecular pathways involved in IBD.

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Section: Anemia a Common Systemic Complication And/or Extra-intestinmentioning

confidence: 77%

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease

Manfredi

Conte

Barberis

et al. 2019

Journal of Proteomics

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“…Restriction of dairy products seems to be quite common among IBD patients or up to 65 % [ 11 ]. As a possible consequence, inadequate calcium intake has been reported in one third of patients [ 12 ] along with inadequate intake of vitamin D (36 %) [ 8 ] and low serum vitamin D concentrations [ 13 ]. This can be clinically relevant as osteoporosis has been reported among these patients [ 14 – 18 ] and fracture among patients with IBD is 40 % greater than in general population [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study on nutrient intake and -status in inflammatory bowel disease patients

Vidarsdottir

Johannsdottir

Þórsdóttir

et al. 2015

Nutr J

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Background and aimsInflammatory bowel disease (IBD) can be associated with nutritional problems. The aim of this study was to investigate diet and nutritional status of IBD patients.MethodsA total of 78 participants (35 men and 43 women aged 18–74 years) were included in this cross-sectional study. The majority (80 %) of the participant received infliximab treatment. Participants filled out disease related questionnaires and 31 participants also a 3-day food record. Body composition was measured and blood samples analysed in order to estimate nutritional status.ResultsThe majority (87 %) claimed that diet affects digestive tract symptoms and 72 % had changed diet accordingly. The most common foods restricted were dairy products (60 %), processed meat (55 %), soft drinks (46 %), alcohol (45 %) and fast food (44 %). Body mass index was mostly in the overweight range but 46 % of the participants had been diagnosed with some nutritional deficiency since IBD diagnosis (most common was iron deficiency: 39 %). Patients who restricted meat products had lower ferritin values (48 ± 39 vs. 95 ± 74 μg/L, P = 0.011). Intake of vitamin D and calcium were not adequate (65 % below recommeded intake for both) and 60 % had poor vitamin D status.ConclusionIBD patients often change their dietary intake in order to affect digestive tract symptoms. Many patients have a history of nutrient deficiency. Restriction of dairy and meat consumption is common and is negatively associated with intake or status of micronutrients like calcium and iron. Dietary advice by a dietitian and use of potentially helpful dietary supplements is indicated.

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“…Heaney (18) has argued that the functional outcomes of vitamin D and calcium interaction in vivo may be reflected by "synergistic effects of vitamin D status and calcium intake on calcium absorption," "effects of calcium intake on vitamin D status," and "potential association between calcium and vitamin D status and non-skeletal outcomes" such as cancer and inflammatory bowel disease (IBD). For the latter, Vernia et al (19) have indicated that inadequate calcium intake is present in IBD patients and that this represents a reversible risk factor given that diets in these patients contained significantly less calcium than healthy controls. The context that calcium and vitamin D supplementation disparities can be benchmarked on gender, age, race/ethnicities, dietary preferences, and household economics has been widely advocated (20,21), but the review of Wallace et al (20) pointed out that "low-income, overweight and/or obese minority population may be at greater risk of calcium and vitamin D insufficiency."…”

Section: Editorialmentioning

confidence: 99%