Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose–response analysis of observational studies

Hong, Zhi-Qiang; Tian, Changwei; Zhang, Xingliang

doi:10.1007/s10549-012-2172-8

Cited by 28 publications

(19 citation statements)

References 32 publications

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“…The results of a casecontrol study in Australia postulated that the risk of breast cancer rises significantly with 25(OH)D levels lower than 30 ng/ml [19]. Similar results in a meta-analysis by Hong and others suggested a nonlinear relationship between serum vitamin D levels and risk of breast cancer, so that women with [20]. Interestingly, although not conclusive, in our study the 25(OH)D level of those in the fourth quartile who had 3 times lower risk than those in the first quartile was 29.5 ng/ml or above.…”

Section: Vitamin D and Breast Cancer In Iranian Womenmentioning

confidence: 75%

Vitamin D Status and Risk of Breast Cancer in Iranian Women: A Case–Control Study

Jamshidi-Naeini

Akbari

Abdollahi

et al. 2016

Journal of the American College of Nutrition

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Section: Vitamin D and Breast Cancer In Iranian Womenmentioning

confidence: 75%

Vitamin D Status and Risk of Breast Cancer in Iranian Women: A Case–Control Study

Jamshidi-Naeini

Akbari

Abdollahi

et al. 2016

Journal of the American College of Nutrition

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“…When the lowest category was open-ended, the lowest boundary was set to zero. 22,23 All statistical analyses were conducted using STATA software (version 12.0; StatCorp., College Station, TX, USA) and p < 0.05 was considered as statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Lü²,

Zhao

et al. 2015

Intl Journal of Cancer

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While several epidemiological studies have investigated the association between vitamin C and risk of esophageal cancer, the results remain inconsistent. In the present study, a meta-analysis was conducted to assess the impact of dietary vitamin C intake on esophageal cancer risk. Online databases were searched up to March 29, 2015, for studies on the association between dietary vitamin C intake and esophageal cancer risk. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-response analyses were performed using the method of restricted cubic splines with four knots at percentiles of 5, 35, 65 and 95% of the distribution. Publication bias was estimated using Egger's tests and funnel plots. In all, 15 articles were included in this meta-analysis, including 20 studies, containing 7063 controls and 3955 cases of esophageal cancer. By comparing the highest vs. the lowest categories of vitamin C intake, we found that vitamin C was inversely associated with the risk of esophageal cancer [overall OR 5 0.58, 95% CI 5 0.49-0.68, I 2 5 56%]. A linear dose-response relationship was found. With an increase in dietary vitamin C intake of 50 mg/day, the risk of esophageal cancer statistically decreased by 13% (OR 5 0.87, 95% CI 5 0.80-0.93, p linearity 5 0.0002). In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer.Esophageal cancer ranks the tenth most common malignancy and the eighth leading cause of cancer-related deaths worldwide. 1 In 2012, [mt]456,000 newly diagnosed cases and 400,000 related deaths were reported. 2 Most esophageal cancer patients are diagnosed at the advanced stages, and the 5-year survival rate is <20%. 3 Thus, primary prevention of esophageal cancer is becoming critical.A large proportion of cases are induced by the action of chemical carcinogens. The epidemiological evidence suggests that alcohol consumption, smoking tobacco, N-nitroso compound and micronutrient deficiency are among the major risk factors for esophageal cancer. [4][5][6] The ultimate reactive and carcinogenic forms of most chemical carcinogens are strong electrophiles. 7 However, vitamin C can prevent carcinogenesis of esophageal cells by blocking the formation of Nnitroso compounds. [8][9][10][11][12] Since the first study that explored the association between vitamin C and esophageal cancer in 1987, 13 a number of epidemiological studies have investigated the relationship between vitamin C intake and esophageal cancer risk. However, these results are controversial. Therefore, we conducted a meta-analysis to assess the association of dietary vitamin C intake and the risk of esophageal cancer, and to evaluate the dose-response relationship of esophageal cancer and vitamin C intake. Material and Methods Search strategyA comprehensive literature search of Pubmed, and Web of Knowledge was conducted before March 2015. The following keywords were used: "esophageal cancer" or...

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“…When the highest category was open-ended, we considered the width of the category to be the same as that of the adjacent category. When the lowest category was open-ended, the lowest boundary was set to zero [51, 52]. To derive the dose-response curve, we modeled folate using restricted cubic splines with four knots at the 5th, 35th, 65th and 95th percentiles of the distribution [53].…”

Section: Methodsmentioning

confidence: 99%

Folate intake, serum folate levels and esophageal cancer risk: an overall and dose-response meta-analysis

Zhao

Guo

et al. 2017

Oncotarget

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Previously reported findings on the association between folate intake or serum folate levels and esophageal cancer risk have been inconsistent. This study aims to summarize the evidence regarding these relationships using a dose-response meta-analysis approach. We performed electronic searches of the Pubmed, Medline and Cochrane Library electronic databases to identify studies examining the effect of folate on the risk of esophageal cancer. Ultimately, 19 studies were included in the meta-analysis. Summary odds ratios (ORs) were estimated using a random effects model. A linear regression analysis of the natural logarithm of the OR was carried out to assess the possible dose-response relationship between folate intake and esophageal cancer risk. The pooled ORs for esophageal cancer in the highest vs. lowest levels of dietary folate intake and serum folate were 0.63 (95% CI: 0.56-0.71) and 0.71 (95% CI: 0.55-0.92), respectively. The dose-response meta-analysis indicated that a 100 μg/day increment in dietary folate intake reduced the estimate risk of esophageal cancer by 12%. These findings suggest that dietary and serum folate exert a protective effect against esophageal carcinogenesis.

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Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose–response analysis of observational studies

Cited by 28 publications

References 32 publications

Vitamin D Status and Risk of Breast Cancer in Iranian Women: A Case–Control Study

Vitamin D Status and Risk of Breast Cancer in Iranian Women: A Case–Control Study

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Folate intake, serum folate levels and esophageal cancer risk: an overall and dose-response meta-analysis

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