Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study

Kallio, Petteri; Kolehmainen, Marjukka; Laaksonen, David E.; Kekäläinen, J; Salopuro, Titta; Sivenius, Katariina; Pulkkinen, Leena; Mykkänen, Hannu; Niskanen, Leo; Uusitupa, Matti; Poutanen, Kaisa

doi:10.1093/ajcn/85.5.1417

Cited by 121 publications

(81 citation statements)

References 46 publications

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“…17 Also other IGFBPs are reported to have similar functions. Brand-Miller et al 18 have shown that the glycemic index of foods acutely changes the IGFBP1 and IGFBP3 concentrations in circulation.…”

Section: Discussionmentioning

confidence: 98%

“…Studies III-IV: FUNGENUT and GENOBIN study We combined two previously published study populations, FUNGENUT 17 and GENOBIN, 24,25 to examine the associations between gene expression of IGFBP5 and adiponectin at baseline. The participants had impaired fasting glycemia, or IGT and at least two other features of the metabolic syndrome according to the National Cholesterol Education Program criteria: waist circumference 4102 cm (males), 488 cm (females); fasting serum triacylglycerol concentration X1.7 mmol l À1 ; fasting serum highdensity lipoprotein cholesterol o1.0 mmol l À1 (males), o1.3 mmol l À1 (females); blood pressure X130/80 mm Hg.…”

Section: Study I: the Finnish Diabetes Prevention Study (Dps)mentioning

confidence: 99%

“…Reverse transcriptase-PCR was then performed as described earlier. 17 Assays were based on TaqMan chemistry and ABI Prism 7500 SDS software (Applied Biosystems). The following assays, Hs01052296_m1 and Hs00605917_m1 (Applied Biosystems product codes for IGFBP5 and adiponectin, respectively) were ordered.…”

Section: Selection Of Snps and Genotype Analysismentioning

confidence: 99%

“…For this purpose we utilized baseline data from FUNGENUT and GENOBIN study populations at baseline. 17,24 The persons recruited to these studies had metabolic syndrome and impaired glucose metabolism similarly to that of the participants in the DPS. The mRNA concentrations of IGFBP5 and adiponectin were highly correlated in all subjects (Po0.001, r 2 ¼ 0.368) and in women (P ¼ 0.001, r 2 ¼ 0.425) (Figure 4).…”

Section: Gene Expression Correlations In Satmentioning

confidence: 99%

“…17 In addition, it has been shown that IGFBP1 and IGFBP3 respond postprandially to the glycemic load of the diet. 18 Both of these findings indicate that IGFBPs are potential markers for nutritional changes in humans with healthy Figure 1 Schematic presentation of the IGFBP5 gene and the locations of the single-nucleotide polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

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Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin

Kallio

Kolehmainen

et al. 2008

Int J Obes

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Background: Insulin-like growth factor binding protein 5 (IGFBP5) binds to IGF and thus modulates IGF signaling pathway. We have shown earlier that the IGFBP5 gene was downregulated in the adipose tissue after 12-week carbohydrate diet with low insulinemic response. Objective: The aim was to examine the putative contribution of genetic variation of the IGFBP5 gene to the characteristics of metabolic syndrome and incidence of type 2 diabetes (T2DM) in the Finnish Diabetes Prevention Study (DPS). Methods: DPS is a longitudinal study where 522 subjects with impaired glucose tolerance were randomized to either lifestyle intervention group or control group. DNA was available from 507 subjects (mean body mass index (BMI) 31.2±4.5 kg/m 2 , age 55 ± 7 years). The eight single-nucleotide polymorphisms (SNPs) were selected from HapMap database and genotyped by Taqman allelic discrimination protocol. The main results were confirmed in a larger cross-sectional study population (METSIM). In addition, the gene expression of IGFBP5 was studied in two previously published study populations (FUNGENUT and GENOBIN) of 124 subjects with insulin resistance (BMI 32.2 ± 3.5 kg/m 2 , age 57.7 ± 7.4 years). Results: Three out of eight IGFBP5 markers (rs9341234, rs3276 and rs11575134) were significantly associated with circulating adiponectin concentrations in men. Furthermore, mRNA expression studies of subcutaneous adipose tissue showed that mRNA concentrations of IGFBP5 correlated with adiponectin concentrations in all subjects and in women. None of the IGFBP5 SNPs were associated with T2DM. Conclusions: Our findings show that IGFBP5 has a gender-specific association with adiponectin, which may modulate the development of metabolic syndrome.

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Section: Discussionmentioning

confidence: 98%

Section: Study I: the Finnish Diabetes Prevention Study (Dps)mentioning

confidence: 99%

Section: Selection Of Snps and Genotype Analysismentioning

confidence: 99%

Section: Gene Expression Correlations In Satmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin

Kallio

Kolehmainen

et al. 2008

Int J Obes

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Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods

Bagchi¹,

Lau²,

Bagchi³

2010

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Bagchi v pevné vazbě, 688 stran vyd. Wiley-Blackwell, 2.vydání, X/2015 ISBN 9781118930427 katalogová cena cca 6.990 Kč vč.DPH v této nabídce 5.730 Kč vč.DPH (tato cena platí při objednání titulu do 31.12.2015)Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals.A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

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Rye

Poutanen¹,

Katina

Heiniö

2014

Bakery Products Science and Technology

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Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study

Abstract: Dietary carbohydrate modification with rye and pasta or oat, wheat, and potato differentially modulates the gene expression profile in abdominal subcutaneous adipose tissue, even in the absence of weight loss.

Cited by 121 publications

References 46 publications

Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin

Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin

Genomics, Proteomics, and Metabolomics in Nutraceuticals and Functional Foods

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