Dietary chitooligosaccharide supplementation alleviates intestinal barrier damage, and oxidative and immunological stress in lipopolysaccharide-challenged laying hens

Gu, Yunfeng; Chen, Y.P.; Jin, Rui; Wang, C.; Cui, Wen; Zhou, Yanmin

doi:10.1016/j.psj.2022.101701

Cited by 22 publications

(18 citation statements)

References 58 publications

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“…These discrepancies may be due to differences in genotype, age, diet composition or environment [ 30 ]. Additionally, dietary COS supplementation did not affect feed intake in laying hens with FLS, which was in agreement with the effect of COS supplementation in laying hens under normal physiological conditions [ 18 , 21 ].…”

Section: Discussionsupporting

confidence: 82%

“…To our knowledge, this is the first time the beneficial effect of COS on egg quality in laying hens with FLS has been reported. Similarly, previous studies on egg quality in laying hens under normal physiological conditions found that COS showed beneficial effects on egg-quality characteristics, including yolk color, eggshell strength, eggshell thickness, albumen height and Haugh unit [ 18 , 19 , 21 , 31 , 32 ]. Although the results were not entirely consistent, it can be concluded that COS is effective in improving egg quality in laying hens with or without FLS.…”

Section: Discussionmentioning

confidence: 55%

“…When used as an alternative to antibiotics for laying hens, COS could improve production performance and egg quality under normal physiology conditions [ 18 , 19 ]. Moreover, COS could attenuate intestinal oxidative stress and inflammation in laying hens [ 21 ]. COS could also alleviate oxidative stress and inflammation in the livers, spleens and intestines of broilers [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Feng

Fan

Zhao

et al. 2022

Animals

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This study aimed to investigate the role of chitosan oligosaccharide (COS) as an additive in the feed of laying hens with fatty liver syndrome (FLS). Effects on production performance, egg quality as well as ovarian function were determined. A total of 360 Lohmann Pink-shell laying hens (28 weeks old) were randomly assigned to 5 groups (6 replicates × 12 birds). Hens were fed with a basal diet and a high-energy low-protein (HELP) diet supplemented with 0, 200, 400 and 800 mg/kg COS. COS reversed the lowered laying rates, increased feed-to-egg ratios and decreased albumen heights and Haugh units induced by the HELP diet. Additionally, COS improved the ovarian morphologies damaged by the HELP diet. Furthermore, COS enhanced antioxidant enzyme activities, reduced malonaldehyde levels and downregulated the mRNA expressions of nuclear factor kappa B, pro-inflammation cytokine genes and pro-apoptosis-related genes, while it upregulated the mRNA expression of anti-apoptosis-related genes in the ovaries of HELP-diet-fed hens. These findings suggested that dietary COS supplementation could improve production performance and egg quality in laying hens with FLS, and these beneficial effects were linked to improved ovarian morphology, which was attributed to decreased oxidative stress, inflammation and apoptosis in the ovaries.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

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Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Feng

Fan

Zhao

et al. 2022

Animals

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“…Moreover, the intestine mucosal barrier represents the first line of the host defence against invading enteric pathogens and toxins, which plays key roles in nutrient digestion and absorption ( Turner, 2009 ). LPS stimulation can cause intestinal barrier damage, oxidation and immune stress, and then affect the intestinal development and growth performance of livestock and poultry ( Gu et al, 2022 ). Tight junctions (TJs) are protein complexes in intestinal epithelial cells that can regulate intestinal epithelial permeability and maintain the intestinal barrier integrity ( Suzuki, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary resveratrol supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged with lipopolysaccharide

Xiong

et al. 2022

Front. Microbiol.

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Resveratrol (RES) displays strong antioxidant and anti-inflammatory properties in protecting the animals from various stressors and inflammatory injuries, but its interrelationship with the gut microbiota remained largely unclear. This study was carried out to investigate the effects of dietary RES supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged by lipopolysaccharide (LPS). A total of 240 yellow-feathered broilers were randomly assigned to four treatment groups in a 2 × 2 factorial design. The broilers were fed with the control diet or control diet supplemented with 400 mg/kg RES, followed by challenge with LPS or the same amount of saline. Dietary RES supplementation significantly alleviated the decreases in the final body weight (BW), average daily gain (ADG), and ADFI induced by LPS (P < 0.05). LPS challenge significantly increased plasma concentrations of triglyceride, high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), and cortisol levels, but decreased triiodothyronine (T3) and insulin levels (P < 0.05). Dietary supplementation with RES significantly reversed the elevated creatinine concentrations and the decreased concentrations of T3 and insulin caused by LPS (P < 0.05). Moreover, dietary RES supplementation significantly increased plasma total antioxidant capacity (T-AOC) and catalase (CAT) activities and superoxide dismutase (SOD) and T-AOC activities in jejunal mucosa and reduced malondialdehyde (MDA) concentration in the plasma (P < 0.05). The reduction in the villus height to crypt depth ratio in duodenum, jejunum and ileum and the shortening of villus height in jejunum and ileum caused by LPS were also alleviated by RES treatment (P < 0.05). Furthermore, the increased concentrations of intestinal tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β caused by LPS were significantly decreased by RES treatment (P < 0.05). Dietary RES treatment increased the mRNA expression of claudin-1, claudin-5, occludin, and zonula occludens-1 (ZO-1), and decreased mRNA expression of IL-1β, IL-8, IL-17, and TNF-α after LPS challenge (P < 0.05). Dietary RES treatments significantly decreased the dominance of cecal microbiota, and increased the Pieiou-e and Simpson index. Moreover, dietary RES supplementation increased relative abundance of UCG_ 009, Erysipelotrichaceae, Christensenellaceae_R-7_group, Anaerotruncus, RF39, and Ruminococcus while decreasing the abundance of Alistipes at genus level. Spearman correlation analysis revealed that the microbes at the order and genus levels significantly correlated with indicators of growth performance, antioxidant capacity, and intestinal health. Collectively, dietary supplementation with 400 mg/kg RES could improve growth performance and antioxidant capacity, and modulate intestinal immunity in yellow-feathered broilers challenged by LPS at early stage, which might be closely associated with the regulation of gut microbiota community composition.

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“…It has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury [ 2 , 3 , 4 , 5 , 6 , 7 ]. Moreover, the accumulation of excessive free radicals [ 8 ] induced by LPS damaged the intestinal barrier [ 9 ] and decreased the growth performance of broilers [ 10 ] by triggering inflammation of the gastrointestinal tract [ 11 ], initiating oxidative damage and apoptosis of intestinal epithelial cells [ 12 , 13 ], and disrupting intestinal microbial composition and metabolism [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide

Tang

Shu

et al. 2023

Molecules

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Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic acid (FA) isolated from multiple plants exhibits multiple biological activities. This study investigated whether FA ameliorated intestinal function and microflora in LPS-challenged Tianfu broilers. The results showed that LPS challenge impaired intestinal function, as evidenced by decreased antioxidant functions (p < 0.05), disrupted morphological structure (p < 0.05), and increased intestinal permeability (p < 0.05); however, these adverse effects were improved by FA supplementation. Additionally, FA supplementation preserved sIgA levels (p < 0.05), increased mRNA expression levels of CLDN and ZO-1 (p < 0.05), and enhanced epithelial proliferation (p < 0.05) in the ileal mucosa in LPS-challenged chickens. Moreover, FA supplementation rectified the ileal microflora disturbances in the LPS-challenged broilers. The results demonstrate that dietary FA supplementation decreased LPS-induced intestinal damage by enhancing antioxidant capacity and maintaining intestinal integrity. Furthermore, FA supplementation protects intestinal tight junctions (TJs), elevates secretory immunoglobulin A (sIgA) levels, and modulates ileal microflora composition in LPS-challenged broilers.

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Dietary chitooligosaccharide supplementation alleviates intestinal barrier damage, and oxidative and immunological stress in lipopolysaccharide-challenged laying hens

Cited by 22 publications

References 58 publications

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Effect of dietary resveratrol supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged with lipopolysaccharide

Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide

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