Dietary chlorogenic acid regulates gut microbiota, serum-free amino acids and colonic serotonin levels in growing pigs

Wu, Yi; Liu, Wenhui; Qi, Li; Li, Yafei; Yan, Yizhe; Huang, Fang; Wu, Xin; Zhou, Quancheng; Shu, Xugang; Ruan, Zheng

doi:10.1080/09637486.2017.1394449

Cited by 47 publications

(32 citation statements)

References 30 publications

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“…In the study of Wu et al. (2018), dietary CGA changed the diversity of intestinal flora, improved intestinal mucosal barrier function and increased the serum levels of free essential, non‐essential and total amino acids in pig. The serum free amino acids are the main source for free amino acids and protein synthesis in muscle.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the higher free amino acid contents in the QC group than in control may be attributed to the increase in oxaloacetate and ketoglutarate in TCA cycle, which could produce delicious amino acids and other non-essential amino acids by transamination. In the study of Wu et al (2018)…”

Section: Effects Of Eu Active Compounds On the Flesh Fatty Acids Anmentioning

confidence: 99%

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Effects of three active components in Eucommia ulmoides on growth and flesh quality of grass carp ( Ctenopharyngodon idellus ) based on transcriptomics

Yang

et al. 2020

Aquacult. Nutr.

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Grass carp (Ctenopharyngodon idellus) is an important cultured freshwater fish with the highest production of 5.52 million tons in 2017, accounting for 6.89% of the finfish aquaculture in the world (FAO, 2019). With the increase in intensive aquaculture, the flesh quality of grass carp showed a declining trend, which has become a growing public concern. In the future, the production increase will not be the primary goal in aquaculture, while obtaining high-quality fish products based on a sustainable aquaculture is becoming an important task for the industry (Kobayashi et al., 2015). As a traditional herb widely used in East Asia, Eucommia ulmoides (EU) has been found many functions including enhancing bones' strength, antioxidant capacity and immunity and reducing body fattiness (Hussain et al., 2016). In recent years, EU has been used as feed additive in pig

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Eu Active Compounds On the Flesh Fatty Acids Anmentioning

confidence: 99%

Effects of three active components in Eucommia ulmoides on growth and flesh quality of grass carp ( Ctenopharyngodon idellus ) based on transcriptomics

Yang

et al. 2020

Aquacult. Nutr.

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“…in the cecum [ 48 ]. In growing pigs, CGA enhanced gut microbiota diversity, the serum free-AA levels (aspartic acid, threonine, alanine, and arginine), and the colonic 5-HT level [ 49 ].…”

Section: Organic Acidsmentioning

confidence: 99%

Dietary Supplementation of Inorganic, Organic, and Fatty Acids in Pig: A Review

Ferronato

Prandini

2020

Animals

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Reduction of antibiotic use has been a hot topic of research over the past decades. The European ban on growth-promoter use has increased the use of feed additivities that can enhance animal growth performance and health status, particularly during critical and stressful phases of life. Pig farming is characterized by several stressful periods, such as the weaning phase, and studies have suggested that the proper use of feed additives during stress could prevent disease and enhance performance through modulation of the gastrointestinal tract mucosa and microbiome. The types of feed additive include acids, minerals, prebiotics, probiotics, yeast, nucleotides, and phytoproducts. This review focuses on commonly used acids, classified as inorganic, organic, and fatty acids, and their beneficial and potential effects, which are widely reported in the bibliography. Acids have long been used as feed acidifiers and preservatives, and were more recently introduced into feed formulated for young pigs with the goal of stabilizing the stomach pH to offset their reduced digestive capacity. In addition, some organic acids represent intermediary products of the tricarboxylic acid cycle (TCA), and thus could be considered an energy source. Moreover, antimicrobial properties have been exploited to modulate microbiota populations and reduce pathogenic bacteria. Given these potential benefits, organic acids are no longer seen as simple acidifiers, but rather as growth promoters and potential antibiotic substitutes owing to their beneficial action on the gastrointestinal tract (GIT).

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“…Wu et al [61] investigated the effects of CGA on the regulation of the gut microbiota, using a 16 S rRNA gene-targeted metagenomic approach, and on the levels of tryptophan and 5-HT. Ninetysix healthy growing pigs were assigned to either standard feed plus 0.05% 3-caffeoylquinic Acid (3-CQA) CGA or a control group, and were observed for 60 days.…”

Section: Gut-microbiota and Serotonin Metabolismmentioning

confidence: 99%

The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis

Stasi

Sadalla

Milani

2019

CDM

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Background:: Serotonin (5-HT) has a pleiotropic function in gastrointestinal, neurological/psychiatric and liver diseases. The aim of this review was to elucidate whether the gut-microbiota played a critical role in regulating peripheral serotonin levels. Methods:: We searched for relevant studies published in English using the PubMed database from 1993 to the present. Results: : Several studies suggested that alterations in the gut-microbiota may contribute to a modulation of serotonin signalling. The first indication regarded the changes in the composition of the commensal bacteria and the intestinal transit time caused by antibiotic treatment. The second indication regarded the changes in serotonin levels correlated to specific bacteria. The third indication regarded the fact that decreased serotonin transporter expression was associated with a shift in gut-microbiota from homeostasis to inflammatory type microbiota. Serotonin plays a key role in the regulation of visceral pain, secretion, and initiation of the peristaltic reflex; however, its altered levels are also detected in many different psychiatric disorders. Symptoms of some gastrointestinal functional disorders may be due to deregulation in central nervous system activity, dysregulation at the peripheral level (intestine), or a combination of both (brain-gut axis) by means of neuro-endocrine-immune stimuli. Moreover, several studies have demonstrated the profibrogenic role of 5-HT in the liver, showing that it works synergistically with platelet-derived growth factor in stimulating hepatic stellate cell proliferation. Conclusion:: Although the specific interaction mechanisms are still unclear, some studies have suggested that there is a correlation between the gut-microbiota, some gastrointestinal and liver diseases and the serotonin metabolism.

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Dietary chlorogenic acid regulates gut microbiota, serum-free amino acids and colonic serotonin levels in growing pigs

Cited by 47 publications

References 30 publications

Effects of three active components in Eucommia ulmoides on growth and flesh quality of grass carp ( Ctenopharyngodon idellus ) based on transcriptomics

Effects of three active components in Eucommia ulmoides on growth and flesh quality of grass carp ( Ctenopharyngodon idellus ) based on transcriptomics

Dietary Supplementation of Inorganic, Organic, and Fatty Acids in Pig: A Review

The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis

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