Dietary choline supplementation attenuated high-fat diet-induced inflammation through regulation of lipid metabolism and suppression of NFκB activation in juvenile black seabream (<i>Acanthopagrus schlegelii</i>)

Jin, Min; Pan, Tingting; Tocher, Douglas R.; Betancor, Mónica B.; Monroig, Óscar; Shen, Yuedong; Zhu, Tingting; Sun, Peng; Zhou, Qicun

doi:10.1017/jns.2019.34

Cited by 61 publications

(46 citation statements)

References 68 publications

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“…This inflammatory response was slightly alleviated by consuming more choline and removing the choline synthesis inhibitor, AMP. As mentioned earlier, choline supplementation has been demonstrated to attenuate pro-inflammatory response in juvenile black seabream intestine and liver by down-regulating nfb and tnf mRNA expressions (31) . This might be the case for juvenile YTK fed a choline-deficient diet.…”

Section: Liver Histologymentioning

confidence: 84%

“…For example, supplementing choline to a high-lipid diet was reported to reduce liver lipid content, cell damage, and inflammatory response (i.e. down-regulate NFκB expression) in juvenile black seabream (Acanthopagrus schlegelii) (31) . Choline supplementation also prevented signs of lipid malabsorption syndrome in post-smolt Atlantic salmon (Salmo salar L.) but had little effect on liver lipid metabolism (44) .…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

et al. 2020

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Choline plays a crucial role in lipid metabolism for fish, and its deficiency in aquafeed has been linked to compromised health and growth performance. A 56-d experiment was conducted to examine the effects of dietary choline on lipid composition, histology, and plasma biochemistry of yellowtail kingfish (Seriola lalandi; YTK; 156 g initial body weight). The dietary choline content ranged from 0.59 to 6.22 g/kg diet. Three grams of 2-amino-2-methyl-1-propanol (AMP)/kg was added to diets, except for a control diet, to limit de novo choline synthesis. The results showed that the liver lipid content of YTK was similar among diets containing AMP and dominated by free fatty acids (FFA). In contrast, fish fed the control diet had significantly elevated liver triacylglycerol (TAG). Generally, the saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA) content of liver lipid in fish fed diets containing AMP was not influenced by choline content. The SFA and MUFA of liver lipid in fish fed the control diet was similar to other diets except for a decrease in PUFA. The linear relationship between lipid digestibility and plasma cholesterol was significant, otherwise most parameters were unaffected. When AMP is present, higher dietary choline reduced the severity of some hepatic lesions. This study demonstrated that choline-deficiency affects some plasma and liver histology parameters in juvenile YTK which might be useful fish health indicators. Importantly, this study elucidated potential reasons for lower growth in choline-deficient YTK and increased the knowledge on choline metabolism in the fish.

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Section: Liver Histologymentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

et al. 2020

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“…Srebp-1 is a transcription factor responsible for regulating cholesterol and fatty acid/lipid biosynthesis pathways (54,57) . Fas is involved in de novo fatty acid synthesis (28) . G6pd and 6pgd participate in NADPH production and are important genes for fatty acids biosynthesis (58) .…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al (1) reported that black sea bream is prone to store lipid in their liver. Previous studies in black sea bream reported that L-carnitine (27) , choline (28) and bile acids (10) supplementation could improve immune and antioxidative abilities and reduce the histopathological changes caused by HL diets. The present study aimed to investigate whether BBR supplementation in HL diet could effectively reduce lipid accumulation in the liver of black sea bream.…”

mentioning

confidence: 96%

Dietary berberine regulates lipid metabolism in muscle and liver of black sea bream (Acanthopagrus schlegelii) fed normal or high-lipid diets

Wang

Sagada

et al. 2020

Br J Nutr

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This study investigated the influence of berberine (BBR) supplementation in normal and high lipid diets on lipid metabolism and accumulation in black sea bream (Acanthopagrus schlegelii). Berberine was supplemented at 50 mg/kg to control (Con, 11.1% crude lipid) and high lipid (HL, 20.2% crude lipid) diets and named as ConB and HLB, respectively. After the 8-week feeding trial, fish body length and specific growth rate were significantly reduced by high lipid diets (P < 0.05). Muscle and whole-body crude lipid contents were significantly influenced by both BBR supplementation and dietary lipid level. Fish fed HLB diet had significantly lower serum triglyceride, low-density lipoprotein cholesterol contents, and alanine aminotransferase activity compared with the HL group. The HL group presented vast lipid accumulation in the liver, and hypertrophied hepatocytes along with large lipid droplets, and translocation of nuclear to the cell periphery. These abnormalities in black sea bream were alleviated in the HLB group. Berberine supplementation in high lipid diet significantly downregulated the hepatic expression levels of accα, srebp-1, 6pgd, g6pd and pparγ, whereas the lpl, hsl, and cpt1a expression levels were significantly upregulated. However, the expression levels of these genes showed opposite trends in muscle (except for pparγ). In conclusion, dietary BBR supplementation in high lipid diet reduced hepatic lipid accumulation by downregulating lipogenesis gene expression and upregulating lipolysis gene expression, and it increased muscle lipid contents with opposite trends of the mechanism observed in the liver.

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“…145 In juvenile black seabream, choline supplementation suppressed NF-κB activation and increased the expression of lipolysis pathway genes. 146 The increased uptake of choline by HCCs cells promotes phospholipid formation, DNA hypermethylation, and hepatocyte proliferation. Gougelet et al showed that choline-deficient diet reverses these effects and promotes regression of HCC that overexpress β-catenin in mice.…”

Section: Methionine Metabolism and Cldsmentioning

confidence: 99%

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Wang

Liang

et al. 2020

Sig Transduct Target Ther

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As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to being a precursor for glutathione synthesis, and the principal methyl donor for nucleic acid, phospholipid, histone, biogenic amine, and protein methylation, methionine metabolites can participate in polyamine synthesis. Methionine metabolism disorder can aggravate the damage in the pathological state of a disease. In the occurrence and development of chronic liver diseases (CLDs), changes in various components involved in methionine metabolism can affect the pathological state through various mechanisms. A methionine-deficient diet is commonly used for building CLD models. The conversion of key enzymes of methionine metabolism methionine adenosyltransferase (MAT) 1 A and MAT2A/MAT2B is closely related to fibrosis and hepatocellular carcinoma. In vivo and in vitro experiments have shown that by intervening related enzymes or downstream metabolites to interfere with methionine metabolism, the liver injuries could be reduced. Recently, methionine supplementation has gradually attracted the attention of many clinical researchers. Most researchers agree that adequate methionine supplementation can help reduce liver damage. Retrospective analysis of recently conducted relevant studies is of profound significance. This paper reviews the latest achievements related to methionine metabolism and CLD, from molecular mechanisms to clinical research, and provides some insights into the future direction of basic and clinical research.

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Dietary choline supplementation attenuated high-fat diet-induced inflammation through regulation of lipid metabolism and suppression of NFκB activation in juvenile black seabream (Acanthopagrus schlegelii)

Cited by 61 publications

References 68 publications

Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

Dietary berberine regulates lipid metabolism in muscle and liver of black sea bream (Acanthopagrus schlegelii) fed normal or high-lipid diets

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

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