Dietary chromium deficiency effect on sperm count and fertility in rats

Anderson, Richard A.; Polansky, Marilyn M.

doi:10.1007/bf02789119

Cited by 23 publications

(9 citation statements)

References 6 publications

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“…In a unique study, Anderson and Polansky (1981) have explored the effect of Cr deficiency on male rats. They found that male rats fed a diet containing < 100 µg/kg had by 50% less sperm cells and fertility lower by 25%.…”

Section: Reproductionmentioning

confidence: 99%

Chromium as an essential nutrient: a review

Pechová¹,

Pavlata²

2007

Vet. Med.

359

244

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Chromium (Cr) has been studied since the end of the 19 th century, when carcinogenic effects of hexavalent Cr were discovered. Essentiality of trivalent Cr was demonstrated in 1959; Cr 3+ has been studied in humans and laboratory animals since the 1970s and it is only since the 1990s that Cr has been studied as an essential element in livestock animals with the same intensity. Trivalent chromium is essential to normal carbohydrate, lipid and protein metabolism. Chromium is biologically active as part of an oligopeptide -chromodulin -potentiating the effect of insulin by facilitating insulin binding to receptors at the cell surface. With chromium acting as a cofactor of insulin, Cr activity in the organism is parallel to insulin functions. Cr absorption is low, ranging between 0.4 and 2.0% for inorganic compounds while the availability of organic Cr is more than 10 times higher. Absorbed Cr circulates in blood bound to the β-globulin plasma fraction and is transported to tissues bound to transferrin. Absorbed Cr is excreted primarily in urine, by glomerular filtration; a small amount is excreted through perspiration, bile and in milk. The demand for Cr has been growing as a result of factors commonly referred to as stressors, especially during different forms of nutritional, metabolic and physical strain. This review describes Cr metabolism, the different biological functions of Cr and symptoms of Cr deficiency.

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Section: Reproductionmentioning

confidence: 99%

Chromium as an essential nutrient: a review

Pechová¹,

Pavlata²

2007

Vet. Med.

359

244

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“…Selenium is necessary for glutathione peroxidase because of its role as an antioxidant in both humans and animals (Moslemi & Tavanbakhsh, 2011). In male rats, insufficient Cr in the diet caused decreased sperm cell counts and fertility (Anderson & Polansky, 1981). However, high Cr levels in seminal plasma had an adverse effect on sperm production, motility and sperm counts in infertile men (Bassey, Essien, Isong, Udoh, & Agbara, 2013).…”

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confidence: 99%

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Waheed

Meligy

Dhalam³

2018

Reprod Domestic Animals

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A total of 14 camels of known fertility (controls) at the Camel Research Centre, King Faisal University and 41 infertile dromedaries brought to the Veterinary Teaching Hospital were used in this study during the breeding season. Seminal plasma and serum were obtained from all males, and stored at -80°C until analysis. Concentrations of six trace elements (manganese [Mn], zinc [Zn], iron [Fe], selenium [Se], copper [Cu] and chromium [Cr]) were estimated in the seminal plasma and serum using an atomic absorption spectrophotometer. Results showed significant (p < 0.05 and p < 0.01) differences in semen pH and sperm motility, concentration and abnormalities between the control and infertile dromedaries. In seminal plasma, a significant (p < 0.01) difference in Fe concentrations (7.792 ± 1.567 vs. 61.259 ± 11.967 mg/L) and significant (p < 0.05) differences in Zn (24.763 ± 8.206 vs. 83.981 ± 4.972 mg/L) and Cu (1.653 ± 0.348 vs. 7.905 ± 1.134 mg/L) concentrations existed between the control and infertile dromedaries, respectively. In serum, there were significant (p < 0.05) differences in Fe (6.237 ± 0.695 vs. 151.121 ± 27.604 mg/L) and Cu (24.703 ± 4.195 vs. 6.375 ± 0.644 mg/L) concentrations and a significant (p < 0.01) difference in Zn concentrations (17.086 ± 1.606 vs. 90.422 ± 4.347 mg/L) between the fertile and infertile camels, respectively. There were significant (p < 0.05) positive (r = 0.51) and negative (r = -0.54) correlations between Zn concentrations in seminal plasma and both sperm motility and sperm abnormalities, respectively. In conclusion, seminal plasma and serum trace elements of Fe, Zn and Cu influenced the semen parameters and fertility of dromedary camels. Low concentrations of Fe, Zn and Cu in the seminal plasma were associated with normal fertility in dromedaries.

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“…The best results in motility and sperm concentration were achieved at a dose of 4 μg of chromium per kg of feed ration of chromium; these results however were not statistically signifi cant. In a similar experiment with rats Anderson and Polansky (1981) discovered that the overall sperm count in rats fed a feed ration containing less than 100 μg of chromium per kg of feed ration of chromium decreased. Along with this also successful fertilisation decreased by 25 % as compared with the group which received a supplement of chromium in the feed ration.…”

Section: Discussionmentioning

confidence: 96%

The effect of a supplement of chromium (picolinate) on the level of blood glucose, insulin activity and changes in laboratory evaluation of the ejaculate of breeding boars

Horký¹,

Jančíková²,

Zeman³

2013

Acta Univ. Agric. Silvic. Mendelianae Brun.

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The experiment was based on feeding the organic form of chromium (picolinate) and the assessment of its effect on the level of blood glucose, insulin activity and changes in the laboratory values of the ejaculate (sperm motility, ejaculate volume, sperm concentration and per cent of pathological sperm) in breeding boars. The experiment involved 40 boars divided into two equal groups. Boars of the experimental group (n = 21) received 181.81 μg of chromium per kg of feed ration (FR) administered perorally, in the control group (n = 19) chromium intake was not increased. The chromium supplement significantly (P < 0.05) increased cell absorption of blood glucose in the experimental group of boars as against the control group. There was no difference in insulin activity between the two groups. Changes in laboratory values of the ejaculate were evaluated and no significant differences were discovered in any of the parameters. During the experiment the sperm concentration and motility were absolutely the same in boars of both groups; it can therefore be concluded that increasing the level of chromium in the feed ration of boars of the experimental group had no direct effect on these parameters. It was the same in the case of the ejaculate volume which gradually decreased between periods 1 and 4, in boars receiving chromium by 12.8 % and in the control group by 8.1 %. The beneficial effect of chromium was seen in the reduced count of pathological sperm in boars in periods 3 and 4 of tests as against boars of the control group. In spite of the considerable 26.3 % difference between the groups this decrease was not statistically significant. Data evaluation revealed a significant correlation (P < 0.01) between the number of samplings per boar and sperm concentration. A correlation (P < 0.05) was also detected between the ejaculate volume and sperm concentration

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Dietary chromium deficiency effect on sperm count and fertility in rats

Cited by 23 publications

References 6 publications

Chromium as an essential nutrient: a review

Chromium as an essential nutrient: a review

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

The effect of a supplement of chromium (picolinate) on the level of blood glucose, insulin activity and changes in laboratory evaluation of the ejaculate of breeding boars

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