Dietary citric acid supplementation alleviates soybean meal-induced intestinal oxidative damage and micro-ecological imbalance in juvenile turbot,<i>Scophthalmus maximus</i>L

Chen, Zhichu; Zhao, Sifan; Liu, Yang; Yang, Peng; Ai, Qinghui; Zhang, Wenbing; Xu, Weiqi; Zhang, Yongan; Zhang, Yan-Jiao; Mai, Kangsen

doi:10.1111/are.13847

Cited by 37 publications

(32 citation statements)

References 88 publications

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“…The results showed that dietary SBM significantly increased the abundance of Bacteroidetes, and decreased the abundance of Proteobacteria compared with FM group. The increased abundance of Bacteroidetes was consistent with previous studies carried out on turbot fed with soybean meal 3,10,14 . Bacteria of Bacteroidetes phylum possess a lot of genes encoding for carbohydrate-degrading enzymes, and are considered primary degraders of polysaccharides 45 .…”

Section: Discussionsupporting

confidence: 91%

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Liu

et al. 2021

Sci Rep

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Soybean meal-induced enteropathy (SBMIE) is prevalent in aquaculture. The aim of this study is to evaluate the role of daidzein on SBMIE of juvenile turbot (Scophthalmus maximus L.) by feeding with fish meal diet (FM), soybean meal diet (SBM, 40% fish meal protein in FM replaced by soybean meal protein) and daidzein diet (DAID, 40 mg/kg daidzein supplemented to SBM) for 12 weeks. We found that daidzein supplementation elevated the gene expression of anti-inflammatory cytokine TGF-β, decreased gene expression of pro-inflammatory cytokines TNF-α and signal molecules p38, JNK and NF-κB. SBM up-regulated the genes expression related to oxidative stress and apoptosis, but dietary daidzein restored it to the similar level with that in FM group. Moreover, dietary daidzein up-regulated gene expression of tight junction protein, and modified the intestinal microbial profiles with boosted relative abundance of phylum Proteobacteria and Deinococcus–Thermus, genera Sphingomonas and Thermus, species Lactococcus lactis, and decreased abundance of some potential pathogenic bacteria. In conclusion, dietary daidzein could ameliorate SBM-induced intestinal inflammatory response, oxidative stress, mucosal barrier injury and microbiota community disorder of turbot. Moreover, p38, JNK and NF-κB signaling might be involved in the anti-inflammatory process of daidzein, and daidzein itself might act as an antioxidant to resist SBM-induced oxidative damage.

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Section: Discussionsupporting

confidence: 91%

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Liu

et al. 2021

Sci Rep

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“…This effect may have been caused by a reduction in peeling losses, caused by the toxins of pathogenic bacteria, resulting in an increase in villus size and, consequently, a greater area for nutrient absorption and improved intestinal health (Viola & Vieira, ). A beneficial effect of organic acids on intestinal integrity was also observed by Chen et al, (), who found that citric acid supplementation at 1.5% and 3.0% in the diet of juvenile sole Scophthalmus maximus for 12 weeks was able to mitigate oxidative damage induced by soybean meal in the diet, as it reduced the imbalance of the intestinal microbiota and reduced the relative abundance of bacteria of the genus Vibrio in the intestinal tract.…”

Section: Discussionsupporting

confidence: 60%

Dietary organic acids blend alone or in combination with an essential oil on the survival, growth, gut/liver structure and de hemato‐immunological in Nile tilapia Oreochromis niloticus

et al. 2019

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This study evaluated the effects of dietary supplementation of organic acids blend (OAB) alone or in combination with essential oil, Lippia origanoides (OAE) for Nile tilapia fed supplemented diets for 30 days. Fish (1.1 ± 0.04 g) were fed control (Control), or OAB 0.5% or OAB 0.5% + essential oil 0.125% (OAE) respectively. At the end of the experiment, samples were collected for de hemato‐immunological, histological analysis of the intestine and liver, as well as microbiology of the intestine. The pH of the diets supplemented with OAB and OAE reduced 0.92 and 0.19 respectively. The growth and FCR were unaffected by the treatments, but survival was significantly higher in the OAB treatment. Fish fed the OAB diet showed reduced concentration of total heterotrophic bacteria and Pseudomonas sp. in the intestine. Increased glucose in fish fed OAB and high number of circulating monocytes in fish fed OAE diet were observed. The anterior intestine of fish fed OAE diet showed larger number of goblet cells and increased villi height. The diet supplemented with OAB, mainly, improved the intestinal health and survival of tilapia juveniles and can be used in juvenile production.

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“…Many studies have shown that oxidative stress are largely accompanied by inflammation, thus leading to tissue damage (72) . In regard to SBMIE-affected turbots, Chen et al (73) and Tan et al (4) have reported that soybean meal may induce oxidative stress in the turbot intestine by elevating the intestinal MDA content and also decreasing the intestinal total antioxidant capacity and the transcript levels of antioxidant enzymes, including SOD, GPx, heme oxygenase 1 and peroxiredoxin 6. It has been considered that these antioxidant enzymes are consumed upon defense against the oxidation caused by soybean meal (4) .…”

Section: Discussionmentioning

confidence: 99%

Chitosan and chitooligosaccharides attenuate soyabean meal-induced intestinal inflammation of turbot (Scophthalmus maximus): possible involvement of NF-кB, activator protein-1 and mitogen-activated protein kinases pathways

Pan

et al. 2021

Br J Nutr

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An 8-week feeding experiment was conducted to investigate and confront the putative functions of chitosan (CTS) and chitooligosaccharide (COS) in the growth and homeostasis of distal intestine in juvenile turbots fed diets containing soybean meal. Three isolipidic and isonitrogenous diets were formulated by supplemented basal diet (based on a 400 g kg-1 soybean meal) with 7.5 g kg-1 CTS or with 2.0 g kg-1 COS. Our results indicated that both CTS and COS supplementation could significantly improve (i) the growth performance and feed efficiency ratio; (ii) antioxidant activity driven by metabolic enzymes (i.e. catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase); (iii) glutathione levels; (iv) acid phosphatase and lysozyme activity and (v) immunoglobulin M (IgM) content. As a result, these two particular prebiotics were able to significantly attenuate the histological alterations due to local inflammation as well as to decrease the transcriptional levels of proinflammatory cytokines (i.e. IL-1β, IL-8 and TNF-α) and major pathway effectors (i.e. AP-1, NF-кB, p38, JNK and ERK). High throughput sequencing data indicated that dietary CTS and COS could significantly decrease the diversity of intestinal bacteria but elevate the relative abundances of Bacillus, Lactobacillus and Pseudomonas genera. Altogether, these findings suggest that CTS and COS can improve growth of turbot, enhance intestinal immune and anti-oxidant systems and promote the balance of intestinal microbiota. The protective effects, elicited by these two prebiotics, against SBM-induced inflammation could be attributed to their roles in alleviating the overexpression of inflammatory cytokines by possibly down-regulating NF-кB, AP-1 and/or MAPK pathways.

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Dietary citric acid supplementation alleviates soybean meal-induced intestinal oxidative damage and micro-ecological imbalance in juvenile turbot,Scophthalmus maximusL

Cited by 37 publications

References 88 publications

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Dietary organic acids blend alone or in combination with an essential oil on the survival, growth, gut/liver structure and de hemato‐immunological in Nile tilapia Oreochromis niloticus

Chitosan and chitooligosaccharides attenuate soyabean meal-induced intestinal inflammation of turbot (Scophthalmus maximus): possible involvement of NF-кB, activator protein-1 and mitogen-activated protein kinases pathways

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