Dietary citrus flavonoid extract improves lactational performance through modulating rumen microbiome and metabolites in dairy cows

Yu, Shiqiang; Li, Liuxue; Zhao, Huiying; Zhang, Shuyue; Yan, Tiebin; Liu, Ming; Zhao, Yuxing; Jiang, Linshu

doi:10.1039/d2fo02751h

Cited by 12 publications

(15 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings suggest that CFE can exert positive selective pressure on the rumen through the interactions between rumen microbes and genes, ultimately regulating rumen resistance and toxicity. For example, as previous studies have shown, CFE can significantly alter the abundance of Lentisphaerae, which may be an important factor leading to changes in ARG and VFG (Yu et al, 2023). The correlation analysis indicates a strong correlation between Lentisphaerae and 10.3389/fmicb.2023.1201262 Frontiers in Microbiology 09 frontiersin.org multiple ARGs and VFGs, but the specific reasons require further investigation.…”

Section: Discussionmentioning

confidence: 70%

“…Our latest research reported that CFE significantly improved milk performance by regulating the ruminal microbiota composition and function in dairy cows (Yu et al, 2023). The hostmicrobe interactions are crucial for the expression of ARG, colonization, and communication (Zhou et al, 2010;Capra and Laub, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Based on our previous study (Yu et al, 2023), only the rumen fluid samples from dairy cows of fed the CON and CFE at 150 g/d (CFE150) were used for metagenomic analysis. DNA extraction was performed using the standard protocol of the E.Z.N.A.…”

Section: Rumen Fluid Collection and Metagenome Sequencingmentioning

confidence: 99%

“…It is known that flavonoids are anti-inflammatory and anti-oxidative polyphenols, which have been shown to alter bacterial cell membrane permeability and inhibit bacterial cell wall synthesis (Song et al, 2022). Our previous study reported that feeding citrus flavonoid extracts (CFE) improved lactational performance by modulating rumen microbiota composition and function (Yu et al, 2023). However, there is limited research on the effect of natural phytochemicals on the expression of ARGs and VFGs in the rumen of dairy cows.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Citrus flavonoid extracts alter the profiling of rumen antibiotic resistance genes and virulence factors of dairy cows

Yu,

Li,

Zhao

et al. 2023

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

Citrus flavonoid extracts (CFE) have the potential to reduce rumen inflammation, improve ruminal function, and enhance production performance in ruminants. Our previous studies have investigated the effects of CFE on the structure and function of rumen microbiota in dairy cows. However, it remains unclear whether CFE affects the prevalence of antibiotic resistance genes (ARG) and virulence factors genes (VFG) in the rumen. Therefore, metagenomics was used to identify the rumen ARG and VFG in lactating dairy cows fed with CFE diets. The results showed that CFE significantly reduced the levels of Multidrug and Antiphagocytosis in the rumen (p < 0.05) and increased the levels of Tetracycline, Iron uptake system, and Magnesium uptake system (p < 0.05). Furthermore, the changes were found to have associations with the phylum Lentisphaerae. It was concluded that CFE could be utilized as a natural plant product to regulate virulence factors and antibiotic resistance of rumen microbiota, thereby improving rumen homeostasis and the health of dairy cows.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Rumen Fluid Collection and Metagenome Sequencingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Citrus flavonoid extracts alter the profiling of rumen antibiotic resistance genes and virulence factors of dairy cows

Yu,

Li,

Zhao

et al. 2023

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, it is documented that the interaction between the gastrointestinal tract of ruminant animals and polyphenols plays a crucial role in mediating the promotion of host health by plant-derived polyphenols. For instance, these interactions can influence the structure and community of the gastrointestinal microbiota, promoting beneficial bacteria and inhibiting harmful bacteria (Yu et al, 2023). The gut microbiota of ruminant animals can further metabolize active substances such as polyphenols, thereby enhancing their bioavailability and utilization (Bhat et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Dried tea residue can alter the blood metabolism and the composition and functionality of the intestinal microbiota in Hu sheep

Guo,

Yu,

Cao

et al. 2023

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

Ruminant animals face multiple challenges during the rearing process, including immune disorders and oxidative stress. Green tea by-products have gained widespread attention for their significant immunomodulatory and antioxidant effects, leading to their application in livestock production. In this study, we investigated the effects of Dried Tea Residue (DTR) as a feed additive on the growth performance, blood biochemical indicators, and hindgut microbial structure and function of Hu sheep. Sixteen Hu sheep were randomly divided into two groups and fed with 0 and 100 g/d of DTR, respectively. Data were recorded over a 56-day feeding period. Compared to the control group, there were no significant changes in the production performance of Hu sheep fed with DTR. However, the sheep fed with DTR showed a significant increase in IgA (p < 0.001), IgG (p = 0.005), IgM (p = 0.003), T-SOD (p = 0.013), GSH-Px (p = 0.005), and CAT (p < 0.001) in the blood, along with a significant decrease in albumin (p = 0.019), high density lipoprotein (p = 0.050), and triglyceride (p = 0.021). DTR supplementation enhanced the fiber digestion ability of hindgut microbiota, optimized the microbial community structure, and increased the abundance of carbohydrate-digesting enzymes. Therefore, DTR can be used as a natural feed additive in ruminant animal production to enhance their immune and antioxidant capabilities, thereby improving the health status of ruminant animals.

show abstract

Dietary secoisolariciresinol diglucoside crude extract improves growth through modulating rumen bacterial community and epithelial development in lambs

Liu,

Yu,

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUNDFlaxseed lignans, types of polyphenolic compounds, primarily consist of secoisolariciresinol diglucoside (SDG). Natural plant extracts are becoming increasingly important as feed for ruminant animals. An underutilized plant bioactive component, SDG shows promising benefits for young ruminant production. The objective of this study was to assess the impact of SDG on rumen fermentation using an in vitro rumen simulation technology. Additionally, we tested the effects of SDG (0.20 g kg−1 body weight) on rumen development and production performance of lambs in a production setting.RESULTSThe in vitro addition of 100 mg L−1 SDG demonstrated significant regulatory effects, with a notable decrease in the acetate/propionate ratio (P < 0.05). Feeding trials revealed that SDG significantly increased average daily feed intake and average daily weight gain (P < 0.05), and reduced the acetate/propionate ratio (P < 0.05). This led to a significant increase in the relative abundance of Eubacterium ruminantium (P = 0.038) and Butyrivibrio (P = 0.002). Furthermore, it promoted rumen development and upregulated the relative expression of mRNA of Cyclin E1 and CDK2 in rumen epithelial cells (P < 0.05).CONCLUSIONThe SDG extract optimizes the composition of rumen microbiota and the development of rumen epithelial cells, promoting the growth of pre‐weaning lambs. The SDG additive exhibits potential as a novel growth promoter for ruminant animals, offering a promising solution for sustainable livestock production. © 2024 Society of Chemical Industry.

show abstract

Dietary citrus flavonoid extract improves lactational performance through modulating rumen microbiome and metabolites in dairy cows

Abstract: The effects of dietary supplementation with citrus flavonoids extract (CFE) on milk performance, rumen fermentation, rumen microbiome, rumen metabolome, and serum antioxidant indexes were evaluated. Eight multiparous lactating cows were...

Cited by 12 publications

References 64 publications

Citrus flavonoid extracts alter the profiling of rumen antibiotic resistance genes and virulence factors of dairy cows

Citrus flavonoid extracts alter the profiling of rumen antibiotic resistance genes and virulence factors of dairy cows

Dried tea residue can alter the blood metabolism and the composition and functionality of the intestinal microbiota in Hu sheep

Dietary secoisolariciresinol diglucoside crude extract improves growth through modulating rumen bacterial community and epithelial development in lambs

Contact Info

Product

Resources

About