Dietary coenzyme Q₁₀ may improve the growth performance and antioxidant status in quails exposed to cold stress

The effect of dietary coenzyme Q10 supplementation on egg quality and liver histopathology of layer quails under cadmium challenge

“…Our histopathological findings further show that supplementation of CoQ10 attenuated the deleterious oxidative stress and hepatocyte necrosis resulting from Cd exposure. This ameliorative action of CoQ10 may be due to the free radical scavenging activity of CoQ10 (Bayril et al, 2020; Formigli et al, 2003; Polak et al, 2011).…”

“…The supplementation of CoQ10 in broiler diets improved antioxidant capacity and mitochondrial function associated with lower mortality rate (Geng & Guo, 2005). Bayril et al (2020) showed that treatment of cold‐stressed quail with CoQ10 alleviated stress effects and reduced the concentration of hepatic malondialdehyde. Although, Williams (1992) declared that albumen quality is not considerably influenced by the bird's nutrition, there is evidence indicating that albumen height and Haugh units are improved by dietary supplements such as alpha lipoic acid and CoQ10 (Terčič et al, 2011).…”

Glucose supplementation improves intestinal amino acid transport and muscle amino acid pool in pigs during chronic cold exposure

“…Usually, mammals experience active resistance, adaptation and exhaustion during chronic cold exposure and prolonged exposure to low temperatures may lead to irreversible negative effects ( Selye, 1979 ). Extensive data have confirmed that cold limits animal growth and increases feed intake ( Bayril et al., 2020 ; Toghiani et al., 2020 ). More worryingly, long-term cold exposure induces oxidative stress and inflammation in organs, even causing death in animals ( Liu et al., 2019 , 2022 ; Luo et al., 2019 ).…”

Coenzyme Q10 enhances testicular functions and sexual behavior through regulating steroidogenic-related gene expression and inflammatory pathways of Japanese quail (Coturnix japonica) aganist cadmium

“…Numerous research works are focused on the mechanism dynamics of the defensive activities in which CoQ10-administered quails revealed a decline in serum TNF-α and IL-6 expression and hepatic Inos ( Rafieian-Naeini et al., 2022 ). Bayril et al. (2020) reported that CoQ10 has anti-inflammatory impacts in birds subjected to cold stress by constraining nitric oxide, tumor necrosis factor-α (TNF-α), IL-1β, and mitogenic protein kinases; which may indicate that CoQ10 as a probably potent anti-inflammatory drug ( Abdulidha et al., 2020 ).…”

“…CoQ10 also has the exceptional capability to perform as a potent free radical scavenger fat-soluble antioxidant, therefore restraining the damage related to oxidative stress ( Mollaei et al., 2022 ). As well as directly deactivating free radicals, CoQ10 can retain antioxidants like vitamin C (ascorbate) and vitamin E (α-tocopherol) ( Bayril et al, 2020 ). Below 5% of administrated orally, CoQ10 is assumed to spread to the blood circulation, and higher levels of CoQ10 in the plasma are required to stimulate peripheral tissue absorption ( Abdulidha et al., 2020 ).…”