Dietary components and human platelet activity

Abstract

Platelet hyperactivity is one of the most important factors responsible for the incidence of cardiovascular disease. There are many nutritive and non-nutritive compounds present in the diet which may affect platelet function in various ways. Recent discovery of anti-platelet factors in plants, vegetables and fruits provides a new dietary means for a long-term strategy to favorably modify human blood platelet activity. This review summarises the effects of these dietary components on human platelet function both in vitro and in vivo.

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

“…Activated platelets play a crucial role in the pathological development of several arterial disorders, including strokes and acute coronary syndromes, which are initiated by plaque disruption and subsequent platelet-thrombus formation [42–44]. Crataegus extract had effective antiplatelet activity at low doses of 100, 200, and 500 mg/kg as indicated by the increase in bleeding time, decrease in platelet aggregation as assessed by PFA-100, and reduction in serum levels of thromboxane B2 [45].…”

Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

“…With further insight, platelet MPs are now acknowledged as bioactive vascular effectors, a storage pool for procoagulant phospholipids and a key modulator of the hemostatic balance. Indeed, elevated levels of circulating platelet MPs are observed in diseases of vascular involvement and high platelet aggregation activity [9], and platelet aggregation which is initiated by platelet activation is an early event in the development of thrombosis [10]. Hence, platelet MPs are now considered as one of the reliable markers of platelet hyperactivity in determining the risk of cardiovascular and thrombotic diseases.…”

Common carp (Cyprinus caprio) and European catfish (Sillurus glanis) from the Danube River as sources of fat soluble vitamins and fatty acids

“…PUFAs can affect platelet function by interacting with membrane proteins and serving as Supported by the National Science Fund, Ministry of Education and Science of Bulgaria, Project No. DVU 440/2008. precursors for secondary messengers (Dutta-Roy 2002). Their effect depends on the fatty acid (FA) chain length and the degree of saturation.…”