Dietary Conjugated Linoleic Acids Alter Serum IGF-I and IGF Binding Protein Concentrations and Reduce Bone Formation in Rats Fed (<i>n</i>-6) or (<i>n</i>-3) Fatty Acids

Li, Yong; Seifert, Mark F.; Ney, Denise M.; Grahn, Mike; Grant, A.L.; Allen, Kim; Watkins, Bruce A.

doi:10.1359/jbmr.1999.14.7.1153

Cited by 154 publications

(125 citation statements)

References 46 publications

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“…PUFAs also increase alkaline phosphatase (ALP) activity in growing male rats as well as insulin-like growth factor I (IGF-1) and insulin-like growth factor binding protein (IGFBP) levels ( [28][29][30]. Both n-6 and n-3 PUFAs seem to be required for growth.…”

Section: Figurementioning

confidence: 99%

“…Dietary PUFAs may up-regulate or down-regulate IGF-I production in bone via their ability to modulate local concentrations of the AA metabolite PGE 2 [30,48,78]. PGE 2 also promotes the expression of various IGF-binding proteins [77,80,82] suggesting that PGE 2 could keep IGF available for stimulation of osteoblasts at a later phase of bone remodeling [77].…”

Section: Effects Of Dietary Polyunsaturated Fatty Acids and Their Promentioning

confidence: 99%

“…Li et al [30] showed that feeding a fish oil-enriched diet to rapidly growing male rats increases the serum concentration of IGFBP-3, an important modulator of IGF-I and overall bone growth and development. Though little data on the in vitro effect of PUFAs on IGF-1 are available, IGF-1 may be involved in the observed effects of PUFAs on osteoclastogenesis.…”

Section: Effects Of Dietary Polyunsaturated Fatty Acids and Their Promentioning

confidence: 99%

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Long-chain polyunsaturated fatty acids: Selected mechanisms of action on bone

Kruger

Coetzee

Haag

et al. 2010

Progress in Lipid Research

144

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Section: Figurementioning

confidence: 99%

Section: Effects Of Dietary Polyunsaturated Fatty Acids and Their Promentioning

confidence: 99%

Section: Effects Of Dietary Polyunsaturated Fatty Acids and Their Promentioning

confidence: 99%

See 1 more Smart Citation

Long-chain polyunsaturated fatty acids: Selected mechanisms of action on bone

Kruger

Coetzee

Haag

et al. 2010

Progress in Lipid Research

144

View full text Add to dashboard Cite

“…53,54 For example, in rodents, CLA deceases body fat accretion by inhibiting adipocyte lipoprotein lipase activity, 34,35 enhances immune function, 54 suppresses carcinogenesis, 20 scavenges free radicals, 54 and possesses anti-inflammatory activity in bone. 24 〈lpha-lipoic acid (␣-LA) is a disulfide mitochondrial coenzyme and potent antioxidant that increases mitochondrial function and metabolic rates in aged rats. 17,44 In humans, ␣-LA supplementation reduced low-density lipoprotein oxidative damage 27 and improved nerve function in diabetic neuropathy.…”

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confidence: 99%

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

et al. 2005

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Corticosteroid therapy for Duchenne muscular dystrophy is effective but associated with long-term side effects. To determine the potential therapeutic benefit from four nutritional compounds (creatine monohydrate, conjugated linoleic acid, ␣-lipoic acid, and ␤-hydroxy-␤-methylbutyrate) alone, in combination, and with corticosteroids (prednisolone), we evaluated the effects on several variables in exercising mdx mice. Outcome measures included grip strength, rotarod performance, serum creatine kinase levels, muscle metabolites, internalized myonuclei, and retroperitoneal fat pad weight. In isolation, each nutritional treatment showed some benefit, with the combination therapy showing the most consistent benefits. Prednisolone and the combination therapy together provided the most consistent evidence of efficacy; increased peak grip strength (P Ͻ 0.05), decreased grip strength fatigue (P Ͻ 0.05), decreased number of internalized myonuclei (P Ͻ 0.01), and smaller retroperitoneal fat pad stores (P Ͻ 0.001). This study provided evidence for therapeutic benefit from a four-compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD.

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“…Additionally, CLA may reduce the rate of bone formation [3] and enhance immunological responses [4,5]. Natural CLA is mainly present in ruminant products such as meat, milk and dairy products which constitute the major source of dietary CLA for humans.…”

Section: Introductionmentioning

confidence: 99%

In vitro metabolism of rumenic acid in bovine liver slices

et al. 2005

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-Ruminant products are the major source of CLA for humans. However, during periods of fat mobilization, the liver might play an important role in CLA metabolism which would limit the availability of the latter for muscles and milk. In this context, rumenic acid (cis-9, trans-11 CLA) metabolism in the bovine liver (n = 5) was compared to that of oleic acid (n = 3) by using the in vitro liver slice method. Liver slices were incubated for 17 h in a medium containing 0.75 mM of FA mixture and 55 µM of either [1-14 C] rumenic acid or [1-14 C] oleic acid at 37 °C under an atmosphere of 95% O 2 -5% CO 2 . Rumenic acid uptake by liver slices was twice (P = 0.009) that of oleic acid. Hepatic oxidation of both FA (> 50% of incorporated FA) led essentially to the production of acidsoluble products and to a lower extent to CO 2 production. Rumenic acid was partly converted (> 12% of incorporated rumenic acid) into conjugated C18:3. CLA and its conjugated derivatives were mainly esterified into polar lipids (71.7%), whereas oleic acid was preferentially esterified into neutral lipids (59.8%). Rumenic acid secretion as part of VLDL particles was very low and was onefourth lower than that of oleic acid. In conclusion, rumenic acid was highly metabolized by bovine hepatocytes, especially by the oxidation pathway and by its conversion into conjugated C18:3 for which the biological properties need to be elucidated. rumenic acid / oleic acid / metabolism / liver / bovine Abbreviations: ASP, acid-soluble products; BSA, bovine serum albumin; CLA, conjugated linoleic acid; FA, fatty acids; NL, neutral lipids; PL, polar lipids; VLDL, very-low density lipoproteins.

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Dietary Conjugated Linoleic Acids Alter Serum IGF-I and IGF Binding Protein Concentrations and Reduce Bone Formation in Rats Fed (n-6) or (n-3) Fatty Acids

Cited by 154 publications

References 46 publications

Long-chain polyunsaturated fatty acids: Selected mechanisms of action on bone

Long-chain polyunsaturated fatty acids: Selected mechanisms of action on bone

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

In vitro metabolism of rumenic acid in bovine liver slices

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