Dietary copper intake in artificially fed infants.

Salim, Sherman; Farquharson, James; Arneil, Gavin C.; Cockburn, F.; Forbes, G. I.; Logan, R. W.; Sherlock, Jc; Wilson, Tazewell

doi:10.1136/adc.61.11.1068

Cited by 24 publications

(6 citation statements)

References 18 publications

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“…Studies in human infants show that even over this range of Cu intake, Cu status remains largely unchanged, as assessed by serum Cu concentration and ceruloplasmin activity (24,25,30,31). This suggests that Cu absorption in infants may be tightly regulated; however, little is known about the regulation of Cu absorption and transport mechanisms.…”

mentioning

confidence: 95%

Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model

Bauerly¹,

Kelleher²,

Lönnerdal³

2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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Infants are exposed to variable copper (Cu) intake; Cu in breast milk is low, whereas infant formulas vary in Cu content as well as the water used for their preparation. Little is known about the regulation of Cu absorption during infancy. The objectives of this study were to determine effects of Cu supplementation on Cu absorption and tissue distribution and the expression of Cu transporters in an infant rat model. Suckling rat pups were orally dosed with 0, 10, or 25 microg Cu/day. Intestine and liver were collected at days 10 and 20, and Cu concentration, Cu transporter-1 (Ctr1), Atp7A, Atp7B, and metallothionein (MT) mRNA and protein levels were measured. 67Cu absorption was measured at days 10 and 20. Total 67Cu absorption decreased, and intestinal 67Cu retention increased with increased Cu intake. At day 10, intestine Cu concentration, MT mRNA, and Ctr1 protein levels increased with supplementation, but no changes in Atp7A or Atp7B levels were observed. At day 20, intestine Cu concentration was unaffected by Cu supplementation, but Ctr1 protein and Atp7A mRNA and protein levels were higher than in controls. In liver, Cu level reflected Cu intake at days 10 and 20. There was a significant increase in Ctr1, Atp7B, and MT mRNA expression in liver at both ages with Cu supplementation. In conclusion, the ability of suckling rat pups to tolerate varying amounts of dietary Cu may be due to changes in Cu transporters, facilitated by transcriptional and posttranslational mechanisms. Despite these adaptive changes, Cu supplementation resulted in elevated alanine aminotransferase levels, suggesting a risk of Cu toxicity with supplementation during infancy.

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mentioning

confidence: 95%

Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model

Bauerly¹,

Kelleher²,

Lönnerdal³

2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Despite the growing understanding of the physiological role of copper many clinical problems remain unresolved. For example, it is not yet clear whether current recommendations for copper intake in artificially fed infants are appropriate, nor is it known whether the copper in proprietary infant feeding formulae is adequate in amount, or sufficiently bio-available [2]. Asymptomatic copper deficiency may be much commoner in normally growing pre-term infants than has hitherto been recognised [3].…”

mentioning

confidence: 99%

Copper Deficiency in Infancy

Paterson

Burns

1988

J. Clin. Biochem. Nutr.

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“…In the literature [15,32,39] the plasma zinc levels at birth range from 14.53 gmol/1 to 19.7 gmol/1, in our study the plasma zinc concentration was 14.17 gmol/1 (SD _+ 3.06). Due to supplementation the hypo-allergenic formula had higher zinc and copper contents than the others.…”

Section: Zincmentioning

confidence: 74%

“…At birth the plasma copper concentration in our study was 6.09 btmol/1 (SD _+ 2.17); in the literature [15,32,33] the plasma copper value ranges from 4.56 gmol/1 to 7.2 btmol/1. Newborns have high liver copper concentrations and low plasma copper values [16,17,21,24,25].…”

Section: Coppermentioning

confidence: 96%

Zinc and copper in infants fed breast-milk or different formula

Lombeck

Fuchs

1994

Eur J Pediatr

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In 129 term infants at birth and at the age of 4 months, zinc and copper concentrations of plasma and urine were determined by graphite furnace atomic absorption spectrophotometry and the values correlated to other biochemical parameters and somatic data. Of the infants, 49 were exclusively breast-fed, 44 fed with various commercially available cow's milk formula, 35 fed with a hypoallergenic formula (cows's milk whey hydrolysate, commercially available, supplemented with zinc and copper). Plasma zinc values declined from birth to the age of 4 months in all three groups (P < 0.001). In formula fed children, 4 months old, the values (11.1 +/- 1.7 mumol Zn/l) were significantly lower than in breast-fed (12.2 +/- 1.7 mumol Zn/l; P = 0.004) or babies on hypo-allergenic formula (12.4 +/- 1.6 mumol Zn/l; P = 0.0015). In accordance with the literature plasma copper and caeruloplasmin values increased significantly within the first 4 months of life, the plasma levels were similar in either feeding group, only urinary copper excretion was higher in male infants on hypo-allergenic formula (P < 0.03) at the age of 4 months. There were no correlations between zinc or copper values and alkaline phosphatase. In infants on hypo-allergenic formula there was a negative correlation between plasma zinc and weight or height increments. Despite different zinc and copper supply, presumedly different bioavailability, and different plasma zinc values, all infants thrived and weight and length increments were similar in each group.

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Dietary copper intake in artificially fed infants.

Cited by 24 publications

References 18 publications

Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model

Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model

Copper Deficiency in Infancy

Zinc and copper in infants fed breast-milk or different formula

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