Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses’ Health Study cohorts

Schernhammer, Eva; Feskanich, Diane; Niu, Caroline; Dopfel, Regina; Holmes, Michelle D.; Hankinson, Susan E.

doi:10.3945/ajcn.2009.27826

Cited by 20 publications

(12 citation statements)

References 60 publications

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“…This has two explanations, which are as follows: it is a lipophilic compound that easily diffuses through biological barriers to enter cells, and it is rapidly metabolized, mainly in the liver [191] to 6‐sulfatoxymelatonin. This compound is a recognized major urinary metabolite of melatonin [192]. Therefore, the short half‐life of melatonin should not be associated with urinary loss but with its rapid uptake into cells.…”

Section: Desirable Properties Of Free Radical Scavengersmentioning

confidence: 99%

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano¹,

Tan²,

Reíter³

2011

Journal of Pineal Research

1,023

826

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: Oxidative stress has been proven to be related to the onset of a large number of health disorders. This chemical stress is triggered by an excess of free radicals, which are generated in cells because of a wide variety of exogenous and endogenous processes. Therefore, finding strategies for efficiently detoxifying free radicals has become a subject of a great interest, from both an academic and practical points of view. Melatonin is a ubiquitous and versatile molecule that exhibits most of the desirable characteristics of a good antioxidant. The amount of data gathered so far regarding the protective action of melatonin against oxidative stress is overwhelming. However, rather little is known concerning the chemical mechanisms involved in this activity. This review summarizes the current progress in understanding the physicochemical insights related to the free radical–scavenging activity of melatonin. Thus far, there is a general agreement that electron transfer and hydrogen transfer are the main mechanisms involved in the reactions of melatonin with free radicals. However, the relative importance of other mechanisms is also analyzed. The chemical nature of the reacting free radical also has an influence on the relative importance of the different mechanisms of these reactions. Therefore, this point has also been discussed in detail in the current review. Based on the available data, it is concluded that melatonin efficiently protects against oxidative stress by a variety of mechanisms. Moreover, it is proposed that even though it has been referred to as the chemical expression of darkness, perhaps it could also be referred to as the chemical light of health.

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Section: Desirable Properties Of Free Radical Scavengersmentioning

confidence: 99%

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano¹,

Tan²,

Reíter³

2011

Journal of Pineal Research

1,023

826

View full text Add to dashboard Cite

show abstract

“…Additionally, in a study conducted with young, middle-aged and elderly participants (20 ± 10 year-old, 45 ± 10 year-old and 75 ± 10 year-old, respectively), the total antioxidant capacity were reported to significantly increase in the three groups of individuals after the intake of the experimental juice of grape ( Vitis vinifera cv. Tempranillo), 200 mL twice a day (as the lunch and dinner desserts) for 5 days [ 76 ] as well as the urinary 6-sulfatoxymelatonin, a major metabolite of melatonin commonly used as a biomarker indicating its bioavailability [ 79 ]. Moreover, it was found in vivo in 12 healthy male volunteers that the consumption of tropical fruit (banana) or fruit juices (orange and pineapple) significantly increased the serum melatonin concentration and the highest value was observed at 120 min after intake, i.e., compared with before consumption, pineapple with 146 pg/mL versus 48 pg/mL ( p = 0.002), orange with 151 pg/mL versus 40 pg/mL ( p = 0.005), and banana with 140 pg/mL versus 32 pg/mL ( p = 0.008), respectively.…”

Section: Dietary Sources Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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“…Additionally, in a clinical trial with enrolment of young, middle-aged and elderly participants, the total antioxidant capacity after the intake of the experimental juice of the grape ( Vitis vinifera cv. Tempranillo) increased significantly in all the groups [ 171 , 173 ], suggesting that the consumption of foods rich in phytomelatonin could be able to provide many health benefits [ 11 ]. Moreover, recently Sae-Teaw et al [ 139 ] showed that the consumption of banana or fruit juices (orange and pineapple) significantly increased the serum melatonin concentration and especially at 120 min after the intake, in healthy male volunteers.…”

Section: Melatonin and Potential Nutritional Impact In Health And mentioning

confidence: 99%

Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases

et al. 2018

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In the therapeutic strategies, the role of diet is a well-established factor that can also have an important role in liver diseases. Melatonin, identified in animals, has many antioxidant properties and it was after discovered also in plants, named phytomelatonin. These substances have a positive effect during aging and in pathological conditions too. In particular, it is important to underline that the amount of melatonin produced by pineal gland in human decreases during lifetime and its reduction in blood could be related to pathological conditions in which mitochondria and oxidative stress play a pivotal role. Moreover, it has been indicated that melatonin/phytomelatonin containing foods may provide dietary melatonin, so their ingestion through balanced diets could be sufficient to confer health benefits. In this review, the classification of liver diseases and an overview of the most important aspects of melatonin/phytomelatonin, concerning the differences among their synthesis, their presence in foods and their role in health and diseases, are summarized. The findings suggest that melatonin/phytomelatonin supplementation with diet should be considered important in preventing different disease settings, in particular in liver. Currently, more studies are needed to strengthen the potential beneficial effects of melatonin/phytomelatonin in liver diseases and to better clarify the molecular mechanisms of action.

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Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses’ Health Study cohorts

Abstract: Although no specific nutrients were associated with altered concentrations of melatonin, our findings raise the possibility that several specific foods, including red meat, could affect cancer risk through the lowering of melatonin concentrations.

Cited by 20 publications

References 60 publications

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Dietary Sources and Bioactivities of Melatonin

Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases

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