2010
DOI: 10.1158/1078-0432.ccr-10-0446
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Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

Abstract: Purpose: Glioblastomas are the most common and most deadly primary brain tumors. Here, we evaluated the chemotherapeutic effect of the natural polyphenol curcumin on glioma cells in vitro and in vivo using an immunocompetent orthotopic mouse model.Experimental Design: Curcumin's effects on proliferation, cell cycle, migration, invasion, JAK/STAT3 signaling, STAT3 target gene expression, and STAT3C rescue experiments were determined in murine glioma cell lines in vitro. Therapeutic effects of curcumin in vivo w… Show more

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Cited by 124 publications
(97 citation statements)
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“…This has been observed in multiple studies, although often with varying results depending on the cancer cell line Kunnumakkara et al, 2009;Lin et al, 2010;Weissenberger et al, 2010;Sun et al, 2011). uPA levels were also decreased in curcumin-treated cells, in which inhibition of NF-kB activity was identified as the chief culprit .…”
Section: Ink4amentioning
confidence: 84%
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“…This has been observed in multiple studies, although often with varying results depending on the cancer cell line Kunnumakkara et al, 2009;Lin et al, 2010;Weissenberger et al, 2010;Sun et al, 2011). uPA levels were also decreased in curcumin-treated cells, in which inhibition of NF-kB activity was identified as the chief culprit .…”
Section: Ink4amentioning
confidence: 84%
“…uPA levels were also decreased in curcumin-treated cells, in which inhibition of NF-kB activity was identified as the chief culprit . Similarly, inhibition of tumor metastasis by curcumin has been frequently observed and attributed to the reduction in MMP-2, MMP-9, uPA, and aquaporin 3 protein levels Weissenberger et al, 2010;Wong et al, 2010;Soung and Chung, 2011). Although the mechanism is relatively elusive, aquaporins play a role in tumor growth and metastasis (Nico and Ribatti, 2010), during which MMPs are upregulated via the PI3K-Akt pathway to facilitate these processes.…”
Section: Ink4amentioning
confidence: 99%
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“…Glioblastomas are known to be the most common and most deadly of primary brain tumors [251]. The anti-cancer effects of curcumin were evaluated on glioma cells were evaluated in vitro and in vivo using an immunocompetent orthotopic mouse model.…”
Section: Curcuminmentioning
confidence: 99%
“…The dietary intake of antioxidant foods or supplements may reduce oxidative stress and, subsequently, lessen mtDNA damage (Weissenberger et al, 2010). Generally it is believed that the identification of dietary factors that play a key role in the protection of the mitochondria and the alleviation of symptoms associated with diabetes is crucial to the development of preventive measures.…”
Section: Oxidative Stress and Dietary Antioxidantsmentioning
confidence: 99%