Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats

Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

“…We did not detect significant effect of MeHg on serum IgM level in this study. However, when treated with the same dose of MeHg, rats fed fish oil diet had significantly higher level of IgM than those fed some other diets, suggesting a dramatic influence of fish oil diet on this parameter, as has been shown to occur previously (Hung et al, 1999). More interestingly, while the vehicle control rats fed lard diet had considerably lower serum total IgG level than rats fed other diets, the rats fed seal oil diet had the highest total IgG level which was three times higher than that in the rats fed the lard diet.…”

Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

“…As described above, EPA is a better substrate than DHA for LCAT activity [82]. The displacement of arachidonic acid by EPA in phospholipids increases cyclooxygenase-2-mediated production of PGE 3 , and lipoxygenase-mediated production of LTB 5 , from EPA, with a concomitant reduction in levels of PGE 2 and LTB 4 [90,91,92]. The PGE 2 -to-PGE 3 and LTB 4 -to-LTB 5 switching described by these investigators is likely to be of clinical importance in the in vivo modulation of disease since the EPA-derived products will tend to favour anti-inflammatory, anti-mitotic and anti-allergic activities [90,91,92].…”

Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells

“…Fowler et al [23] found that low dose, short term dietary supplementation with highly purified EPA or DHA can modulate select functional and signaling responses in murine splenic lymphocytes. Hung et al [24] compared the effect of two fish oil preparations with different EPA and DHA contents on immunoglobulin productivity by lymphocytes. They found that EPA in relation to DHA has higher antiallergic activity.…”