Dietary Effect of .GAMMA.-Linolenic Acid on the Lipid Profile of Rat Fed Erucic Acid Rich Oil

Abstract

This study evaluated the effects of dietary supplementation of g-Linolenic acid (18:3n-6, GLA) on the lipid profile of serum and other tissues of rats fed erucic acid (C22:1) rich oil like mustard oil. The rats were fed diet containing 20% mustard oil as erucic acid rich oil and 20% groundnut oil as dietary fat. These groups were kept as reference groups. Another group fed diet containing 20% fat to which evening primrose oil as a source of GLA was blended with mustard oil and groundnut oil at 5% level. The feeding experiment was done for 4 weeks. In another set mustard oil fed group was kept as control while the experimental group was fed evening primrose oil as a source of GLA blended with mustard oil at 2.5% level. The feeding experiment was carried out for 12 weeks. The other dietary components remained same for all the groups. After the scheduled feeding period, it was found that there was no significant change in weight gain, food intake and food efficiency ratio. It was found that dietary GLA resulted in significant decrease in serum triglyceride (TG) and very low density lipoprotein (VLDL) cholesterol and significant increase in high density lipoprotein (HDL) cholesterol in serum in the experimental group. In liver total cholesterol (TC) is significantly higher and in heart and liver TG is significantly lower in GLA fed group.

A Study on Biochemical Properties and Effects of Different Vegetable Oils on Blood Indices in Wistar Rats

“…This results have similarities with previous studied [29,30]. Many reporters have been reported that feeding high levels of rapeseed oil to rats significantly increased cholesterol levels in the adrenal glands and lipidosis in the cardiac tissue and also found that erucic acid may cause some adverse effect in lipid profile of serum [31]. Additionally when rats were fed to diet in combination with coconut oil and sesame oil exhibited significant depletion of serum cholesterol level as compared to mustard oil and slightly increased than control group result showed in Table 3.…”

“…The erucic acid containing mustard oil might be causative factor for increasing LDL. Other researcher also showed this same phenomena [31]. In this study, it was found that sesame oil was decreased LDL than mustard oil group.…”

Dietary Supplementation of Gamma-Linolenic Acid Improves Skin Parameters in Subjects with Dry Skin and Mild Atopic Dermatitis

“…Gamma linolenic acid GLA: 18:3n-6 , which is metabolized from linoleic acid LA: 18:2n-6 , is known for its benefi cial effect such as improvement of lipid profi les 3 or alleviation of premenstrual syndrome PMS 4 . And GLA is also one of the most popular treatments available for dermatitis.…”

Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients

“…The study of Sayantani et al was the only study showing that dietary GLA feeding resulted in significant decrease in serum TG and very low density lipoprotein (VLDL) cholesterol in addition to the significant increase in HDL-C [ 32 ].…”