Dietary Effects on Carcinogenicity of Drugs and Related Compounds

Rogers, Adrianne E.

doi:10.1016/b978-0-12-332550-1.50025-1

Cited by 2 publications

(1 citation statement)

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“…The influence of diet on carcinogenesis is an important example of dietary modulation of response to toxicants, e.g., diets high in fibre and low in energy and fat decrease response to many carcinogens (Department of Health and Human Services 1988). Other dietary factors such as lipotropes also play an important role in resistance to chemical carcinogenesis (Rogers 1978). Nutrients play many structural and catalytic roles in foreign compound detoxification (Williams 1978, Hathcock 1985a.…”

Section: Nutritional Toxicologymentioning

confidence: 99%

Nutritional toxicology: Basic principles and actual problems

Hathcock

1990

Food Additives and Contaminants

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Nutritional toxicology is a specialty that combines the backgrounds and research approaches of nutrition and toxicology. Many problems of substantial importance to health and food safety involve interactions of nutrition process and requirement with the effects of toxicological impact. Solution of these problems requires research that meets the procedural and design criteria of experimental nutrition and these of experimental toxicology. The relationships may be described in three basic categories: (1) influence of nutrition on toxicities; (2) influence of toxicants on nutrition; and (3) toxicities of nutrients. Trypsin inhibitor research, an example of diet impacting on toxicological response, illustrates the necessity of controlling nutritional composition aspects that can confound the results. Prolonged acetaminophen administration provides an example of the effects of toxicants on nutritional requirement and function which could be important for persons with marginal sulphur amino acid intake.

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Section: Nutritional Toxicologymentioning

confidence: 99%