Dietary emulsifier glycerol monodecanoate affects the gut microbiota contributing to regulating lipid metabolism, insulin sensitivity and inflammation

Zhang, Junhui; Yu, Huilin; Wang, Qianqian; Tang, Jun; Shen, Fei; Cai, Hong; Liu, Tao; Feng, Fengqin; Zhao, Minjie

doi:10.1039/d2fo01689c

Cited by 5 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, not all dietary emulsifiers have an adverse effect on health. Glycerol monodecanoate, a medium-chain monoacylglycerol, positively impacts the gut microbiota and improves lipid metabolism, insulin sensitivity, and inflammation 22 .…”

Section: Discussionmentioning

confidence: 99%

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Panyod,

Wu,

Chang

et al. 2024

Commun Biol

View full text Add to dashboard Cite

Dietary emulsifiers are linked to various diseases. The recent discovery of the role of gut microbiota–host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through the lens of gut microbiota. Lecithin, sucrose fatty acid esters, carboxymethylcellulose (CMC), and mono- and diglycerides (MDG) emulsifiers are common dietary emulsifiers with high exposure levels in the population. This study demonstrates that sucrose fatty acid esters and carboxymethylcellulose induce hyperglycemia and hyperinsulinemia in a mouse model. Lecithin, sucrose fatty acid esters, and CMC disrupt glucose homeostasis in the in vitro insulin-resistance model. MDG impairs circulating lipid and glucose metabolism. All emulsifiers change the intestinal microbiota diversity and induce gut microbiota dysbiosis. Lecithin, sucrose fatty acid esters, and CMC do not impact mucus–bacterial interactions, whereas MDG tends to cause bacterial encroachment into the inner mucus layer and enhance inflammation potential by raising circulating lipopolysaccharide. Our findings demonstrate the safety concerns associated with using dietary emulsifiers, suggesting that they could lead to metabolic syndromes.

show abstract

Section: Discussionmentioning

confidence: 99%

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Panyod,

Wu,

Chang

et al. 2024

Commun Biol

View full text Add to dashboard Cite

show abstract

“…However, not all dietary emulsi ers have an adverse effect on health. Glycerol monodecanoate, a medium-chain monoacylglycerol, positively impacts the gut microbiota and improves lipid metabolism, insulin sensitivity, and in ammation 21 .…”

Section: Discussionmentioning

confidence: 99%

Reassessing the safety of dietary emulsifiers through the lens of gut microbiota

Panyod¹,

Chang³

et al. 2023

Preprint

View full text Add to dashboard Cite

Dietary emulsifiers have been linked to various diseases. The recent discovery of the role of gut microbiota-host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through the lens of gut microbiota. Hydrophilic (lecithin (LEC), sucrose esters (SUC), carboxymethylcellulose (CMC)) and lipophilic (mono- and diglycerides (MDG)) emulsifiers are common dietary emulsifiers with high exposure levels in the population. This study proved that SUC and CMC induced hyperglycemia and hyperinsulinemia. MDG impaired circulating lipid and glucose metabolism. Both hydrophilic and lipophilic emulsifiers changed the intestinal microbiota diversity and induced gut microbiota dysbiosis. Hydrophilic emulsifiers have no impact on mucus–bacterial interactions, whereas MDG tended to cause bacterial encroachment into the inner mucus layer and enhance inflammation potential by raising circulating lipopolysaccharide. Our findings demonstrated the safety concerns associated with using dietary emulsifiers, suggesting that they could lead to metabolic syndromes.

show abstract

Food additives and their implication in inflammatory bowel disease and metabolic syndrome

Besedin,

Shah,

Brennan

et al. 2024

Clinical Nutrition ESPEN

View full text Add to dashboard Cite

Dietary emulsifier glycerol monodecanoate affects the gut microbiota contributing to regulating lipid metabolism, insulin sensitivity and inflammation

Abstract: Glycerol monodecanoate (GMD) is a medium-chain monoacylglycerol that possesses emulsifying and antibacterial properties. Common emulsifiers carboxymethylcellulose and polysorbate-80 have been reported to cause intestinal microbiota dysbiosis and metabolic disturbances. While...

Cited by 5 publications

References 53 publications

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Reassessing the safety of dietary emulsifiers through the lens of gut microbiota

Food additives and their implication in inflammatory bowel disease and metabolic syndrome

Contact Info

Product

Resources

About