Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high‐fat fed mice

Lecomte, Manon; Couëdelo, Leslie; Meugnier, Emmanuelle; Plaisancié, Pascale; Létisse, Marion; Benoit, Bérengère; Gabert, Laure; Penhoat, Armelle; Durand, Annie; Pineau, Gaëlle; Joffre, Florent; Géloën, Alain; Vaysse, Carole; Laugerette, Fabienne; Michalski, Marie‐Caroline

doi:10.1002/mnfr.201500703

Cited by 79 publications

(62 citation statements)

References 55 publications

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“…Moreover regarding the impact of PL emulsifiers, including soybean PL into the high fat diet resulted in higher expression of inflammatory markers in adipose tissue, namely leptin, TNF-alpha and MCP-1, together with a higher expression of LBP. In contrast, milk PL did not induce adipose tissue hypertrophy and inflammation, and both plasma LBP concentration and LBP expression in adipose tissue were lower in this group (Lecomte et al, 2016).…”

Section: Importance Of Lps Transportersmentioning

confidence: 57%

“…Mice were fed a high-fat diet containing 20% of lipids (mostly palm oil) or modified diets in which 1.2% of oil has been replaced with 1.2% soybean phospholipids or 1.2% milk phospholipids. The diet containing soybean PL (commonly called soybean lecithin) induced adipose tissue hypertrophy and increased markers of inflammation, including circulating LBP concentration and its expression by the adipose tissue, compared with the high fat diet devoid of PL (Lecomte et al, 2016). Interestingly, milk PL did not induce such effect, which could be partly due to their effect on providing faster triglyceride digestion and absorption compared with soybean PL as also observed in vitro and in mice (Lecomte et al, 2015).…”

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 84%

“…Lower panel: lean and obese subjects were submitted to two different postprandial tests varying by the amount of fat in the meal. (Laugerette et al, 2011(Laugerette et al, , 2012Lecomte et al, 2016). (A) Catheterized rats were forced fed with saline, sunflower oil + saline or an emulsion of sunflower oil in saline using soybean phospholipids (lecithin) as emulsifier and blood was drawn along the postprandial phase.…”

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 99%

“…5). Unlike soybean PL, milk PL in the high fat diet were found to increase the number of colonic goblet cells, thereby possibly contributing to an improved gut barrier that can prevent LPS translocation from the colon to the circulation (Lecomte et al, 2016). Consequences in the field of infant nutrition regarding the metabolic impact of native breastmilk fat globules vs artificially formulated fat droplets would deserve to be elucidated (Bourlieu and Michalski, 2015;Gallier et al, 2015).…”

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 99%

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Dietary lipid emulsions and endotoxemia

Michalski¹,

Vors²,

Lecomte³

et al. 2016

OCL

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-The low-grade inflammation observed in obesity is a risk factor for cardiovascular diseases and insulin resistance. Among factors triggering such inflammation, recent works revealed the role of bacterial lipopolysaccharides (LPS), so-called endotoxins. LPS are naturally present in the gut via the intestinal microbiota. Recent studies show that they can induce in plasma a metabolic endotoxemia after the consumption of unbalanced hyperlipidic meals. This article reviews recent knowledge gained on the role of intestinal lipid absorption and the composition of dietary lipids on: (i) the induction of metabolic endotoxemia, (ii) the types of plasma transporters of LPS and (iii) associated low-grade inflammation. Notably, lipids are present in foods under various physicochemical structures and notably in emulsified form. Our recent works reveal that such structure and the type of emulsifier can modulate postprandial lipemia; recent results on the possible consequences on metabolic endotoxemia will be discussed.Keywords: Nutrition / fat / oil / emulsifier / inflammation Résumé -Émulsions lipidiques alimentaires et endotoxémie. L'inflammation à bas bruit observée en situation d'obésité représente un facteur de risque cardiovasculaire et d'insulinorésistance. Parmi les facteurs responsables de cette inflammation, des travaux récents ont révélé l'implication des lipopolysaccharides bactériens, aussi appelés endotoxines. Ces endotoxines sont naturellement présentes dans le tractus digestif via le microbiote intestinal. Des études récentes montrent qu'elles peuvent générer une endotoxémie métabolique dans le plasma suite à la consommation de repas déséquilibrés hyperlipidiques. L'objectif de cette revue est de faire le point sur les connaissances récentes concernant le rôle de l'absorption intestinale des lipides et de la composition de ces derniers sur : (i) l'établissement d'une endotoxémie métabolique, (ii) la qualité des transporteurs plasmatiques des LPS et (iii) l'inflammation à bas bruit associée. En particulier, les lipides sont présents dans les aliments sous différentes structures physico-chimiques et notamment sous forme émulsionnée. Nos travaux récents montrent que cette structure est à même de moduler la lipémie postprandiale. Des résultats récents sur les possibles conséquences sur l'endotoxémie métabolique sont discutés.

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Section: Importance Of Lps Transportersmentioning

confidence: 57%

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 84%

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 99%

Section: Oil Composition Emulsified Structure and Dietary Emulsifiermentioning

confidence: 99%

See 2 more Smart Citations

Dietary lipid emulsions and endotoxemia

Michalski¹,

Vors²,

Lecomte³

et al. 2016

OCL

Self Cite

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“…This way, all high‐fat diets contained the same amount of milk TG (1.4%) but differed by the amount of MPL (0%, 1.1%, or 1.6% as specifically analyzed). Of note, 1.1% of MPL is equivalent to ≈25 mg SM kg –1 of body weight in a human using the Human Equivalent Dose calculation of the FDA . An additional group was fed a chow diet (low‐fat, LF) to be used as a reference group.…”

Section: Methodsmentioning

confidence: 99%

Milk Polar Lipids in a High‐Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids

Milard

Laugerette

Durand

et al. 2019

Molecular Nutrition Food Res

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Scope Enhanced adiposity and metabolic inflammation are major features of obesity associated with altered gut microbiota and intestinal barrier. How these metabolic outcomes can be impacted by milk polar lipids (MPL), naturally containing 25% of sphingomyelin, is investigated in mice fed a mixed high‐fat (HF) diet . Methods and results Male C57Bl/6 mice receive a HF‐diet devoid of MPL (21% fat, mainly palm oil, in chow), or supplemented with 1.1% or 1.6% of MPL (HF‐MPL1; HF‐MPL2) via a total‐lipid extract from butterserum concentrate for 8 weeks. HF‐MPL2 mice gain less weight versus HF (p < 0.01). Diets do not impact plasma markers of inflammation but in the liver, HF‐MPL2 tends to decrease hepatic gene expression of macrophage marker F4/80 versus HF‐MPL1 (p = 0.06). Colonic crypt depth is the maximum in HF‐MPL2 (p < 0.05). In cecal microbiota, HF‐MPL1 increases Bifidobacterium animalis versus HF (p < 0.05). HF‐MPL2 decreases Lactobacillus reuteri (p < 0.05), which correlates negatively with the fecal loss of milk sphingomyelin‐specific fatty acids (p < 0.05). Conclusion In mice fed a mixed HF diet, MPL can limit HF‐induced body weight gain and modulate gut physiology and the abundance in microbiota of bacteria of metabolic interest. This supports further exploration of how residual unabsorbed lipids reaching the colon can impact HF‐induced metabolic disorders.

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Docosahexaenoic acid‐enriched phospholipids exhibit superior effects on obesity‐related metabolic disorders to egg yolk phospholipids and soybean phospholipids in mice

Liu

Cui

Leng

et al. 2016

Euro J Lipid Sci & Tech

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Bioactive phospholipids (PL) from different origins varied greatly in the chemical constitutions, especially the fatty acid compositions, which might influence its physiological activities in turn. In the study, egg yolk phospholipids (EGG‐PL), soybean phospholipids (SOY‐PL), and marine docosahexaenoic acid‐enriched phospholipids (DHA‐PL) were administered to high fat (HF) diet‐induced obese C57BL/6J mice for 7 weeks to compare their effects on obesity‐related metabolic disorders. EGG‐PL, SOY‐PL, and DHA‐PL significantly decreased epididymal adipose tissue weights, reduced blood pressures and lowered hepatic TG levels. Only DHA‐PL efficiently decreased perirenal adipose tissue weights, and reduced serum glucose, insulin, IL‐6 and TG levels. These three phospholipids significantly decreased delta‐9 desaturation indices, the ratio of oleic acid versus stearic acid, and reduced the enzyme activities and gene expressions of FAS in the liver, while DHA‐PL also markedly reduced mRNA levels of SREBP‐1c and SCD‐1. Hepatic total catalase and peroxisomal β‐oxidation activities were significantly increased after DHA‐PL supplementation. These data indicated that the biological effects of PL with different fatty acid compositions were not completely equivalent and DHA‐PL, rich in n‐3 PUFA, was more efficient in ameliorating obesity‐related metabolic disorders, especially the lipid metabolism, attributing to the better inhibition of SREBP‐1c mediated lipogenesis and the elevation of hepatic lipolysis. Practical applications: This research gives the public the guidance of the dietary intake of bioactive phospholipids from the perspective of nutrition and it supplies informational support for the development of functional foods containing DHA‐PL participating to the prevention of chronic metabolic diseases in humans. In another aspect, this research also provides an important direction for the development and utilization of marine aquatic raw materials since these materials are the best sources of n‐3 polyunsaturated fatty acid enriched‐phospholipids. Dietary egg yolk phospholipids, soybean phospholipids, and marine docosahexaenoic acid‐enriched phospholipids (DHA‐PL) could efficiently improve obesity‐related metabolic disorders in mice. Notably, DHA‐PL, rich in n‐3 PUFA, exhibited the best ameliorative effects, especially on the lipid metabolism, which could be attributed to the better inhibition of SREBP‐1c mediated lipogenesis and the elevation of hepatic lipolysis. Such findings would be useful in the development of functional foods containing DHA‐PL participating to prevent chronic metabolic disease in humans.

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Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high‐fat fed mice

Abstract: Unlike SPL, MPL in the high-fat diet did not induce WAT hypertrophy and inflammation but increased colonic goblet cells. This supports further clinical exploration of different sources of dietary emulsifiers in the frame of obesity outbreak.

Cited by 79 publications

References 55 publications

Dietary lipid emulsions and endotoxemia

Dietary lipid emulsions and endotoxemia

Milk Polar Lipids in a High‐Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids

Docosahexaenoic acid‐enriched phospholipids exhibit superior effects on obesity‐related metabolic disorders to egg yolk phospholipids and soybean phospholipids in mice

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