Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.

Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma‐linolenic acid

“…Diets enriched in fish oil also reduce the amount of LTB, generated via the 5-lipoxygenase pathway in stimulated polymorphonuclear leukocytes (PMN) and monocytes, suppress LTB,-induced PMN chemotaxis and adherence to endothelial cells (2), reduce generation of platelet-activating factor by monocytes (3), and reduce production of interleukin-1 (IL-1) and tumor necrosis factor by peripheral blood monocytes (PBM) (4). Fish oil supplements have therefore been used in attempts to suppress inflammation in experimental models (5)(6)(7) and in patients with rheumatoid arthritis (RA) (3, [8][9][10].…”

Dietary fish oil reduces progression of established renal disease in (NZB × NZW)F1 mice and delays renal disease in BXSB and MRL/1 strains

“…In these experiments, groups of animals were fed diets containing 25% menhaden oil (MO) (by weight) from the time of weaning; additional groups were fed the MO diets beginning at ages 4 months and 5 months (1,2). Although immune abnormalities are detectable early in the life of an (NZB x NZW)FI mouse, overt renal disease, as evidenced by proteinuria, was manifested only after 8 months of age in mice fed control diets (2).…”

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

“…Immune system abnormalities in these mice include increased expression of proto-oncogenes c-myc and cras in splenocytes and thymocytes, production of autoantibodies against a variety of antigens including DNA, and development of immune complexes which localize in the kidneys. Experimentally, dietary supplementation with fish oil lipids suppresses renal disease and prolongs life span in the B/W mouse (53). Our studies showed mean life span of 402• days for FO vs. 267+13 days for corn oil fed animals (54).…”

“…Overabundance and increased activity of Th-1 cells, and pro-inflammatory cytokines, are likely to play a central role in the pathogenesis of lupus erythematosus and other autoimmune diseases. B/W mice spontaneously develop a disease similar to human systemic lupus erythematosus which has been used as an animal model to elucidate the pathogenesis of the disease (53). Immune system abnormalities in these mice include increased expression of proto-oncogenes c-myc and cras in splenocytes and thymocytes, production of autoantibodies against a variety of antigens including DNA, and development of immune complexes which localize in the kidneys.…”