Dietary exposure and biomarkers of arsenic in consumers of fish and shellfish from France

Sirot, Véronique; Guérin, Thierry; Volatier, Jean‐Luc; Leblanc, Jean-Charles

doi:10.1016/j.scitotenv.2008.11.050

Cited by 135 publications

(97 citation statements)

References 42 publications

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“…A recent French study looked not only at dietary arsenic exposure to arsenic from fish and shellfish, but also at arsenic speciation level (Sirot et al, 2009). The highest total arsenic concentrations of 12 to 34 mg/kg were found in bottom dwelling fish species, with the highest concentrations of inorganic arsenic varying from 0.068 to 0.073 mg/kg.…”

Section: Previously Reported Occurrence Resultsmentioning

confidence: 99%

“…Rice, however, appears to be an exception because it contains significant amounts of inorganic arsenic with concentrations often between 0.1 to 0.4 mg arsenic/kg dry mass and sometimes considerably higher Meharg et al, 2009). Although fish and other seafood have a high total arsenic content (typically 2-60 mg arsenic/kg dry mass, SCOOP, 2004;Julshamn et al, 2004), their levels of inorganic arsenic are typically <0.2 mg arsenic/kg dry mass (Edmonds and Francesconi, 1993;Sloth et al, 2005;Sirot et al, 2009). There are, however, some notable exceptions.…”

Section: Inorganic Arsenic Speciesmentioning

confidence: 99%

“…Those samples belonged to the food categories of "fish and fish products", "fish based preparations" and "seafood and seafood products". These speciation data were included in a recently published French study (Sirot et al, 2009). …”

Section: Distribution Of Samples Across Food Categoriesmentioning

confidence: 99%

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Scientific Opinion on Arsenic in Food

2009

EFSA Journal

877

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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Section: Previously Reported Occurrence Resultsmentioning

confidence: 99%

Section: Inorganic Arsenic Speciesmentioning

confidence: 99%

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Scientific Opinion on Arsenic in Food

2009

EFSA Journal

877

220

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“…This viewpoint is fading because metabolites from ingested organoarsenicals are excreted in urine. Therefore, a careful diet history must be taken and/or seafood consumption should be terminated at least 2-3 days before urine collection when using urinary tAs as a biomarker for iAs exposure [141,142]. Also, intake of arsenosugars and/or arsenolipids ingested with seafood results in increased DMA excretion [99,[143][144][145].…”

Section: Biomarkers Of Arsenic Exposurementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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“…Fish are important sources of As in human diet (Baeyens et al, 2009;Sirot et al, 2009). Although in these products, As is mainly present as organic species that are much less toxic, some authors refer that a certain fraction can be found in the toxic inorganic form, so it is always of concern (Moreau et al, 2007;Sirot et al, 2009;Williams et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Levels of arsenic, mercury and selenium inClarias gariepinusfrom Sagua la Grande River, Cuba

Lima

López-Heras

Pedrero

et al. 2013

Ann. Limnol. - Int. J. Lim.

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-This study first reports concentrations of arsenic (As) and selenium (Se) in fish tissue of Clarias gariepinus from Sagua la Grande River in the Villa Clara Province, Cuba. We also confirm the mercury (Hg) levels in these fish obtained previously. Individuals were captured in three areas near Sagua la Grande City, where this fish is a common source of food for the city inhabitants. Concentrations range of As, Hg and Se (in wet weight) were 0.01-0.11 mg.g x1 ; 0.03-0.24 mg.g x1 and 0.75-3.87 mg.g x1 , respectively. As and Se levels were positively correlated (n = 19, r = 0.673, P < 0.05). High levels of Se were found in fish tissue and in 31.6% (n = 6) of individuals captured exceeded the threshold value for Se toxicity, which means that Se is likely to produce adverse consequences on the fish themselves or on the wildlife organisms that eat them. As and Se concentrations were positively correlated with fish weight and length (P < 0.05). Fish from irrigation canal have higher Se concentrations than fish captured in the other two stations. However, no significant differences were found between Hg and As concentrations in fish at the three sampling stations. Finally, as the Se concentrations in C. gariepinus were abnormally high, we suggest the need for studies about Se sources in the zone, the effect of Se in fish and the intake associated with fish consumption.

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Dietary exposure and biomarkers of arsenic in consumers of fish and shellfish from France

Cited by 135 publications

References 42 publications

Scientific Opinion on Arsenic in Food

Scientific Opinion on Arsenic in Food

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Levels of arsenic, mercury and selenium inClarias gariepinusfrom Sagua la Grande River, Cuba

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