Dietary Exposure Assessment of Aflatoxin M1 in Milk and Dairy Products of Latin America

Sibaja, Karen Vanessa Marimón; Garcia, Sabrina de Oliveira; Nogueira, Wesclen Vilar; Oliveira, Francine Kerstner de; Badiale‐Furlong, Eliana; Garda‐Buffon, Jaqueline

doi:10.1080/87559129.2021.1880434

Cited by 9 publications

(2 citation statements)

References 82 publications

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“…In the study of Malissiova et al [ 64 ] in Greece, the ADI of AFM1 for Feta cheese was reported to be 0.01 ng/kg bw/day, which is lower than the lowest ADI obtained (0.04) in the current study. According to a review study by Marimón Sibaja et al [ 71 ], the ADI of AFM1 as a result of milk consumption in Brazil, Costa Rica, Colombia, and Mexico based on studies published from 2003 to 2018 was 2.4, 1.0, 1.2, and 20.9 ng/kg bw/day, respectively. According to the research of Bahrami et al [ 37 ], ADI of AFM1 was reported as 0.018 and 0.249 when inesting raw milk and dairy products in summer and winter, respectively.…”

Section: Resultsmentioning

confidence: 99%

A national systematic literature review for aflatoxin M1 in commonly consumed cheese brands in Iran: Human health risk assessment by Monte Carlo simulation

Massahi,

Kiani,

Sharafi

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

A national systematic literature review for aflatoxin M1 in commonly consumed cheese brands in Iran: Human health risk assessment by Monte Carlo simulation

Massahi,

Kiani,

Sharafi

et al. 2023

Heliyon

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“…Unlike the United States and several developed nations within the European Union, the implementation of the stringent quality control methods for lowering the dietary exposure to mycotoxins is not always feasible. Hence mycotoxin contamination in food and feed pose a major health threat in many underdeveloped and developing countries worldwide (Imade et al, 2021;Marimon Sibaja et al, 2022;Bhardwaj et al, 2023;Sun et al, 2023). Despite years of mitigation efforts, over 5 million people worldwide are at risk of dietary exposure to just aflatoxin (Gummadidala et al, 2019;Eskola et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis

Jesmin,

Cary,

Lebar

et al. 2023

Front. Microbiol.

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Aflatoxins, a family of fungal secondary metabolites, are toxic and carcinogenic compounds that pose an enormous threat to global food safety and agricultural sustainability. Specifically agricultural products in African, Southeast Asian and hot and humid regions of American countries suffer most damage from aflatoxin producing molds due to the ideal climate conditions promoting their growth. Our recent studies suggest that Vibrio gazogenes (Vg), an estuarine bacterium non-pathogenic to plants and humans, can significantly inhibit aflatoxin biosynthesis in the producers. In this study, we investigated the mechanism underlying Vg-dependent aflatoxin inhibition using the prominent aflatoxin producer, Aspergillus flavus. We show that aflatoxin inhibition upon Vg treatment was associated with fungal uptake of Vg-prodigiosin, a red pigment, which was consistently visible inside fungal hyphae during treatment. The association of prodigiosin with aflatoxin inhibition was further evident as Serratia marcescens, another prodigiosin producer, significantly inhibited aflatoxin, while non-producers like Escherichia coli, Staphylococcus aureus, Vibrio harveyi, and Vibrio fischeri did not. Also, pure prodigiosin significantly inhibited aflatoxin biosynthesis. Endocytosis inhibitors, filipin and natamycin, reduced the Vg-prodigiosin uptake by the fungus leading to a significant increase in aflatoxin production, suggesting that uptake is endocytosis-dependent. The Vg treatment also reduced hyphal fusion (>98% inhibition) and branching, which are both endosome-dependent processes. Our results, therefore, collectively support our theory that Vg-associated aflatoxin inhibition is mediated by an endocytosis-dependent uptake of Vg-prodigiosin, which possibly leads to a disruption of normal endosomal functions.

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Detection of aflatoxin M1 in bovine milk from different agro-climatic zones of Chhattisgarh, India, using HPLC-FLD and assessment of human health risks

Pandey¹,

Shakya²,

Patyal³

et al. 2021

Mycotoxin Res

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Dietary Exposure Assessment of Aflatoxin M1 in Milk and Dairy Products of Latin America

Cited by 9 publications

References 82 publications

A national systematic literature review for aflatoxin M1 in commonly consumed cheese brands in Iran: Human health risk assessment by Monte Carlo simulation

A national systematic literature review for aflatoxin M1 in commonly consumed cheese brands in Iran: Human health risk assessment by Monte Carlo simulation

Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis

Detection of aflatoxin M1 in bovine milk from different agro-climatic zones of Chhattisgarh, India, using HPLC-FLD and assessment of human health risks

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