Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

Chen, Rou-An; Wu, Wei-Kai; Panyod, Suraphan; Liu, Po-Yu; Chuang, Hsiao-Li; Chen, Yi‐Hsun; Lyu, Qiang; Hsu, Hua‐Yi; Lin, Ting-Yu; Shen, Ting-Chin David; Yang, Yu-Tang; Zou, Hsin-Bai; Huang, Huai-Syuan; Lin, Yan; Chen, Chieh‐Chang; Ho, Chi‐Tang; Lai, Hsin-Chih; Wu, Ming–Shiang; Hsu, Cheng-Chih; Sheen, Lee‐Yan

doi:10.1128/msystems.00172-22

Cited by 19 publications

(15 citation statements)

References 65 publications

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“…The presence of antibiotic residues in food had also been potentially linked to hepatotoxicity [59,60], carcinogenesis, mutegenesis, reproductive disorders and teratogenicity [55]. Additionally, the presence of antibiotic residues in food and animal feed may affect the gut microbiome causing dysbiosis that can lead to problems suchs as obesity [61], intestinal barrier damage and increased food allergies [62].…”

Section: Antibiotic Resistance and Food Safety: Implications On Publi...mentioning

confidence: 99%

Antibiotic Resistance and Food Safety: Perspectives on New Technologies and Molecules for Microbial Control in the Food Industry

Wu-Wu¹,

Guadamuz-Mayorga²,

Oviedo-Cerdas³

et al. 2023

Preprint

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Antibiotic resistance (ABR) is concerning issue due to its direct and indirect repercusions on public health, since decreased therapeutic effect of certain antibiotic to treatment complications that can cause death. There are several mechanism as to how ABR can be transferred from one microoorganisms to another, and many of them are dependant many environmental factors. The food supply chain is a environment in which ABR gene transfer can occur is multiple pathways, which generate concerns regarding food safety. Here, we summarize relevant mechanisms which are implied in ABR in food supply chain but also we are addressing routes of transmission and prevalence of ABR, implications on public health, and the application of new alternatives to antibiotics such as antimicrobial peptides, mainly bacteriocins, in order to countermeasure ABR.

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Section: Antibiotic Resistance and Food Safety: Implications On Publi...mentioning

confidence: 99%

Antibiotic Resistance and Food Safety: Perspectives on New Technologies and Molecules for Microbial Control in the Food Industry

Wu-Wu¹,

Guadamuz-Mayorga²,

Oviedo-Cerdas³

et al. 2023

Preprint

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“…Colonic bacteria are gram-negative anaerobic bacteria that perform several metabolic activities, including carbohydrate fermentation, production of vitamins B and K, and polysaccharide hydrolysis (Riley et al, 2013;Jung et al, 2018). The dysbiosis of the intestinal microbiota causes metabolic disease (Chen et al, 2022). Antibiotics are one of the most effective drugs in the treatment of diseases, but their excessive use will lead to changes in the intestinal microbiota and antibiotic resistance (Li et al, 2019;Rahman et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…In children, it leads to complications, such as obesity and an increased risk of allergies, caused by changes in the microbiota of the intestines (Li et al, 2019). Exposure to antibiotic residues in childhood interferes with the maturation and colonization of intestinal microbiota (Chen et al, 2022). Furthermore, disruption of microbiota homeostasis leads to neurological disorders, such as anorexia, depression, Alzheimer's, autism, inflammatory bowel diseases, and Parkinson's disease (Van den Abbeele et al, 2013;Piñeiro and Cerniglia, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…According to the reports of the American Food and Drug Administration, 80% of antimicrobials are used to treat livestock that produce food products of animal origin (Rahman et al, 2021). In addition to treating diseases, they are used as a growth stimulant in livestock (Qian et al, 2021;Chen et al, 2022). In the USA, since 1951, the use of antibiotics as a growth promoter for livestock has been allowed (Castanon, 2007).…”

Section: Introductionmentioning

confidence: 99%

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The effect of residual antibiotics in food on intestinal microbiota: a systematic review

Sadighara

Rostami

Shafaroodi

et al. 2023

Front. Sustain. Food Syst.

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IntroductionThe gut microbiota may be altered following changes in diet or exposure to drugs. Humans can be exposed to antibiotic residue in food. People may be exposed to these compounds for years. But in determining the maximum residue level (MRL), the effects of antibiotic residue on the intestinal microbiota are not investigated. Some evidence suggests that antibiotics in small amounts also lead to changes in the intestinal microbiota. Therefore, a systematic study was conducted with the aim of investigating the effect of antibiotic residues in food on the intestinal microbiota.MethodThe main criterion of this research was to investigate the effects of antibiotics at low doses. For this purpose, a search was made in the databases with keywords antibiotic, veterinary antibiotic, food, residue, microbiome, and microbiota. The investigated doses of each of the antibiotics in the studies were compared with their MRL in food.ResultsThe most significant change in the structure and function of the microbiota was made by tetracycline, sulfamethoxazole, cefquinome, florfenicol and tylosin. The lowest observed effect was related to the antibiotics fosfomycin and amoxicillin.DiscussionExposure to antibiotic residues through food is usually a long-term exposure. In vivo studies, changes in the intestinal microbiota were observed. Therefore, it is necessary to inform the breeders and competent authorities in order to comply with the principles of treatment. The gut microbiota may be altered following changes in diet or exposure to drugs.

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“…With this background information, we hypothesize that the use of injectable antimicrobial drugs may have increased in food animals in the U.S. after the implementation of change in VFD regulations, which could increase the detection of violative antibiotic residues in the tissue of food animals in the U.S. Violative antibiotic tissue residues may pose a risk of adverse health effects in humans, such as an increase in resistant bacteria [ 13 , 14 ], allergic reaction [ 14 , 15 ], altering gut microbiota [ 16 ] and obesity [ 16 , 17 ] from consuming such residues. To our knowledge, no study has quantified the association of the VFD rule changes on the presence of violative penicillin, tetracycline, sulfonamide, desfuroylceftiofur, florfenicol, and tilmicosin residues in the tissue of food animals in the US.…”

Section: Introductionmentioning

confidence: 99%

Effect of Changes in Veterinary Feed Directive Regulations on Violative Antibiotic Residues in the Tissue of Food Animals from the Inspector-Generated Sampling in the United States

Sarkar

Okafor

2022

Microorganisms

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The presence of antibiotic residues in the tissue of food animals is a growing concern due to the adverse health effects that they can cause in humans, such as antibiotic resistance bacteria. An inspector-generated sampling (IGS) dataset from the United States National Residue Surveillance Program, collected between 2014 and 2019, was analyzed to investigate the association of changes in the veterinary feed directive (VFD) regulations on the detection of violative penicillin, tetracycline, sulfonamide, desfuroylceftiofur, tilmicosin, and florfenicol, residues in the tissue of food animals. Multivariable logistic regression models were used for analysis. While the animal production class was significantly associated with residue violations for tetracycline, having a sample collection date after the implementation of change in VFD regulations was not. However, the odds of detecting violative sulfonamide and penicillin residues in the tissue of food animals following the implementation of the change in VFD regulations were 36% and 24% lower than those collected before the implementation of the change in VFD regulations period, respectively, irrespective of animal production class. Violative desfuroylceftiofur, tilmicosin, and florfenicol residues in the tissue of food animals were not significantly associated with the implementation of changes in the VFD regulations. Further investigation of the factors that influence the presence of violative antibiotic residues in the tissue of food animals following the change in VFD regulations would lend clarity to this critical issue.

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Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

Cited by 19 publications

References 65 publications

Antibiotic Resistance and Food Safety: Perspectives on New Technologies and Molecules for Microbial Control in the Food Industry

Antibiotic Resistance and Food Safety: Perspectives on New Technologies and Molecules for Microbial Control in the Food Industry

The effect of residual antibiotics in food on intestinal microbiota: a systematic review

Effect of Changes in Veterinary Feed Directive Regulations on Violative Antibiotic Residues in the Tissue of Food Animals from the Inspector-Generated Sampling in the United States

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