Dietary Factors Affect Food Reward and Motivation to Eat

Pandit, Rahul; Mercer, Julian G.; Overduin, Joost; Fleur, Susanne E. la; Adan, Roger A.H.

doi:10.1159/000338073

Cited by 37 publications

(26 citation statements)

References 286 publications

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“…In mice, consumption of HFD is akin to administration of drugs of abuse and environmental enrichment blunts the rewarding effects of drugs (Xu et al, 2007; El Rawas et al, 2009; Pandit et al, 2012). Thus it is possible that environmental enrichment decreases the reward associated with HFD, resulting in protection from diet-induced obesity.…”

Section: Discussionmentioning

confidence: 99%

Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior

et al. 2014

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Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates circadian rhythms in mice. In this study, we sought to determine whether voluntary wheel-running activity could prevent the proximate effects of high-fat diet consumption on circadian organization and behavioral rhythms in mice. Mice were housed with locked or freely rotating running wheels and fed chow or high-fat diet for 1 week and rhythms of locomotor activity, eating behavior, and molecular timekeeping (PERIOD2::LUCIFERASE luminescence rhythms) in ex vivo tissues were measured. Wheel-running activity delayed the phase of the liver rhythm by 4 h in both chow- and high-fat diet-fed mice. The delayed liver phase was specific to wheel-running activity since an enriched environment without the running wheel did not alter the phase of the liver rhythm. In addition, wheel-running activity modulated the effect of high-fat diet consumption on the daily rhythm of eating behavior. While high-fat diet consumption caused eating events to be more evenly dispersed across the 24 h-day in both locked-wheel and wheel-running mice, the effect of high-fat diet was much less pronounced in wheel-running mice. Together these data demonstrate that wheel-running activity is a salient factor that modulates liver phase and eating behavior rhythms in both chow- and high-fat-diet fed mice. Wheel-running activity in mice is both a source of exercise and a self-motivating, rewarding behavior. Understanding the putative reward-related mechanisms whereby wheel-running activity alters circadian rhythms could have implications for human obesity since palatable food and exercise may modulate similar reward circuits.

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Section: Discussionmentioning

confidence: 99%

Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior

et al. 2014

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“…Over time, highly palatable foods may disrupt these appetite regulatory mechanisms (de Macedo et al, 2016; Johnson & Wardle, 2014) and promote hedonic eating (Lerma-Cabrera et al, 2016; Pandit, Mercer, Overduin, la Fleur, & Adan, 2012). Specifically, there is evidence that highly palatable foods can dampen satiety signals, thus leading to overeating.…”

Section: Maintenance Of Famentioning

confidence: 99%

Psychological and Neurobiological Correlates of Food Addiction

Kalon

Hong

Tobin

et al. 2016

International Review of Neurobiology

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Food addiction (FA) is loosely defined as hedonic eating behavior involving the consumption of highly palatable foods (ie, foods high in salt, fat, and sugar) in quantities beyond homeostatic energy requirements. FA shares some common symptomology with other pathological eating disorders, such as binge eating. Current theories suggest that FA shares both behavioral similarities and overlapping neural correlates to other substance addictions. Although preliminary, neuroimaging studies in response to food cues and the consumption of highly palatable food in individuals with FA compared to healthy controls have shown differing activation patterns and connectivity in brain reward circuits including regions such as the striatum, amygdala, orbitofrontal cortex, insula, and nucleus accumbens. Additional effects have been noted in the hypothalamus, a brain area responsible for regulating eating behaviors and peripheral satiety networks. FA is highly impacted by impulsivity and mood. Chronic stress can negatively affect hypothalamic–pituitary–adrenal axis functioning, thus influencing eating behavior and increasing desirability of highly palatable foods. Future work will require clearly defining FA as a distinct diagnosis from other eating disorders.

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“…Palatable food readily stimulates relative caloric over-consumption in both humans and laboratory animals, an outcome related to food reward and possibly to addiction-like processes. Pandit et al [1] review the effects of a range of obesogenic diets on feeding behaviour, leptin resistance and hypothalamic neuropeptide systems, and how the properties of the diet influence these parameters. These interactions could be important in dietary reformulation to limit over-consumption and weight gain.…”

Section: Introductionmentioning

confidence: 99%

“…These interactions could be important in dietary reformulation to limit over-consumption and weight gain. Pandit et al [1] argue that by understanding how and why the composition of the diet affects its reward value and addictive potential, it may be possible to develop novel foods that limit consumption and weight gain. The relationships between food properties and their sensory and physiological effects are discussed.…”

Section: Introductionmentioning

confidence: 99%