Dietary Factors and Risk of Advanced Prostate Cancer

Mwangi, W.; Zhang, J.

doi:10.1016/j.annepidem.2013.06.024

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Prostate cancer (PC) is the second common cancer in the world (Mwangi and Zhang, 2013). Compared to other countries in Asia the incidence of PC is higher in Iran and it is the third common cancer in men and the six common cancer in Iranian population (Radmard, 2010;Pakzad et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Bahrami

Movahed

Teymoori

et al. 2019

Asian Pac J Cancer Prev

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Background:Prostate cancer is the second common cancer in the world. Although some associations between dietary intakes and prostate cancer have been found, the effects of dietary nutrients interactions have not yet evaluated. The aim of this study is to assess the association between nutrient patterns and risk of prostate cancer.Methods and Materials:Ninety-seven patients with prostate cancer and 205 controls were asked about their demographic and dietary intakes using validated questionnaires. To extract nutrient patterns, Principal Component Analysis (PCA) based on the 35 nutrient items were applied. Varimax rotation was used for improving interpretation and minimizing correlation between the factors. Logistic regression was used to determine the odds ratio (OR) with 95% confidence interval (CI) of prostate cancer by higher scores on the nutrient patterns.Results:High adherence to the “plant source” pattern was negatively associated with prostate cancer risk (OR 0.29 for the highest vs. the lowest score tertile; 95% CI= 0.13 – 0.65; P value for trend: <0.003). Similarly, the “antioxidant and fiber” pattern was associated with decreasing risk of prostate cancer (OR 0.06 for the highest vs. the lowest score tertile;95% CI=0.02 – 0.19; P value for trend: <0.001). There was no significant association for the “mixed” and “vitamin and minerals” pattern with risk of prostate cancer.Conclusion:This study confirms the potential and important role of nutrients on prostate cancer risk. Our finding revealed that “antioxidant and fiber” and “plant source” pattern is inversely associated with prostate cancer risk; however, further longitudinal and trial studies are needed to make a firm conclusion.

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Section: Introductionmentioning

confidence: 99%

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Bahrami

Movahed

Teymoori

et al. 2019

Asian Pac J Cancer Prev

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Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model

et al. 2015

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Prostate cancer is the most frequent non-cutaneous malignancy in men. There is strong evidence in rodents that neonatal estrogen exposure plays a role in the development of this disease. However, there is little information regarding the effects of estrogen in human fetal prostate tissue. This study explored early life estrogen exposure, with and without a secondary estrogen and testosterone treatment in a human fetal prostate xenograft model. Histopathological lesions, proliferation, and serum hormone levels were evaluated at 7, 30, 90, and 200-day time-points after xenografting. The expression of 40 key genes involved in prostatic glandular and stromal growth, cell-cycle progression, apoptosis, hormone receptors and tumor suppressors was evaluated using a custom PCR array. Epigenome-wide analysis of DNA methylation was performed on whole tissue, and laser capture-microdissection (LCM) isolated epithelial and stromal compartments of 200-day prostate xenografts. Combined initial plus secondary estrogenic exposures had the most severe tissue changes as revealed by the presence of hyperplastic glands at day 200. Gene expression changes corresponded with the cellular events in the KEGG prostate cancer pathway, indicating that initial plus secondary exposure to estrogen altered the PI3K-Akt signaling pathway, ultimately resulting in apoptosis inhibition and an increase in cell cycle progression. DNA methylation revealed that differentially methylated CpG sites significantly predominate in the stromal compartment as a result of estrogen-treatment, thereby providing new targets for future investigation. By using human fetal prostate tissue and eliminating the need for species extrapolation, this study provides novel insights into the gene expression and epigenetic effects related to prostate carcinogenesis following early life estrogen exposure.

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Dietary Factors and Risk of Advanced Prostate Cancer

Cited by 2 publications

References 47 publications

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model

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