Dietary Factors and Risk of Pancreatic Cancer: a Multi-Centre Case-Control Study in China

Abstract

Background: Pancreatic cancer is the sixth leading cause of cancer death with an increasing trend in China. Dietary intake is believed to play an important role in pancreatic cancer carcinogenesis. The aim of this paper was to evaluate associations between some dietary factors and risk of pancreatic cancer in a multi-centre case-control study conducted in China. Materials and Methods: Cases (n=323) were ascertained from four provincial cancer hospitals. Controls (n=323) were randomly selected from the family members of patients without pancreatic cancer in the same hospitals, 1:1 matched to cases by gender, age and study center. Data were collected with a questionnaire by personal interview. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using conditional logistic regression. Results: Tea intake (OR =0.49; 95%CI: 0.30-0.80) was associated with a half reduction in risk of pancreatic cancer. Reduced vegetable consumption (P trend: 0.04) was significant related to pancreatic cancer. Although no significant association was found for meat and fruit, ORs were all above or below the reference group. A protective effect was found for fruit (OR=1.73 for consumption of 1-2 times/week vs more than 3 times/week; 95%CI: 1.05-2.86). A high intake of meat was associated to a higher risk of pancreatic cancer (OR=0.59 for consumption of 1-2 times /week vs. more than 3 times /week; 95%CI: 0.35-0.97). Conclusions: The present study supports fruit consumption to reduce pancreatic cancer risk and indicates that high consumption of meat is related to an elevated risk. Direct inverse relations with tea and vegetable intake were also confirmed.

Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer

“…The prognosis of patients with advanced stage pancreatic cancer is much worse than for those with early stage disease. Unfortunately, more than 80% of pancreatic cancer patients were in an advanced stage when diagnosed (Huang et al, 2009;Liu et al, 2014) U r i d i n e 5 ' -d i p h o s p h a t e ( U D P ) -glucuronosyltransferases (UGTs) are an important group of phase II drug metabolism enzymes in humans (Tukey and Strassburg, 2000). The human UDPglucuronosyltransferases (UGTs) are a superfamily ofThe UGT enzymes have been divided into two families of proteins termed UGT1 and UGT2, and three subfamilies of proteins termed UGT1A, UGT2A and UGT2B in human beings (Hanioka et al, 2012).…”

Fruit and vegetable intake and pancreatic cancer risk in a population‐based cohort study in Japan

“…In previous cohort studies, no association was found between fruit and vegetable intake and pancreatic cancer risk . However, several case–control studies have suggested an inverse association . To our knowledge, only one Japanese cohort study has been conducted including a small number of Asian participants regarding the association between fruit and vegetable intake and pancreatic cancer risk .…”

“…[19][20][21][22][23][24][25][26] However, several case-control studies have suggested an inverse association. [27][28][29][30][31][32] To our knowledge, only one Japanese cohort study has been conducted including a small number of Asian participants regarding the association between fruit and vegetable intake and pancreatic cancer risk. 26 Furthermore, the results of previous studies, which have taken into account known risk factors such as obesity and smoking, are inconsistent.…”

Nutrients and the Pancreas: An Epigenetic Perspective

“…A meta-analysis [35] reported an inverse relationship between dietary folate intake and pancreatic cancer risk. Additionally, two other case-control studies and several cohort studies observed an inverse relationship [30,31,36,37,38]. The specific mechanism in which folate protects against pancreatic cancer is unknown, however a few are hypothesized.…”

“…Additional case-control studies completed in China and Italy observed a direct inverse relationship between vegetable consumption and pancreatic cancer [36,41]. However, a Canadian case-control demonstrated an increased intake of fresh fruit and cruciferous vegetables in men only was associated with a 49% reduction in risk [42].…”