Dietary factors in established atopic dermatitis

David, T J; Patel, Leena; Ewing, Carol; Stanton, Robert

doi:10.1017/cbo9780511545771.017

Cited by 7 publications

(5 citation statements)

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“…The role of dietary factors in preventing disease is still unclear, although it probably plays a small effect if present. 18 There is clear evidence however, from double-blind placebo-controlled food challenges, that some children with AD have food allergies. There is as yet no reliable simple test for the identification of individual food triggers or for the prediction of outcome after dietary elimination in ad.…”

Section: Environmentmentioning

confidence: 99%

“…There is as yet no reliable simple test for the identification of individual food triggers or for the prediction of outcome after dietary elimination in ad. 18 It is possible that exposure to infections in early life may be an important determinant of AD expression. Thus the`hygiene' hypothesis forwarded by Strachan,19 whereby children living with many other siblings arè protected' from expressing allergic disease because of continuous exposure to other infections, could be the explanation of the link between AD and small family size.…”

Section: Environmentmentioning

confidence: 99%

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Epidemiology of atopic dermatitis

Williams

2000

Clinical and Experimental Dermatology

197

142

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Although research into atopic dermatitis (AD) has been dominated by the study of cells and chemical mechanisms over the last 40 years, the last 7 years has witnessed a respectable growth within the field of AD epidemiology. Significant advances include valid disease definitions that can be used in epidemiological studies, global prevalence studies, and studies which quantify the morbidity and economic cost of the disease. These have all helped to argue the case for more research into AD. Epidemiological studies demonstrating that AD is commoner in wealthier families, linkage with small family size, increased prevalence in migrant groups, and the increasing prevalence of the disease all argue strongly towards an important role for the environment in determining disease expression. Future research gaps include evaluation of gene-environment interactions, better studies of the natural history of AD, and better clinical trials that answer questions that are important to physicians and their patients.

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Section: Environmentmentioning

confidence: 99%

Section: Environmentmentioning

confidence: 99%

Epidemiology of atopic dermatitis

Williams

2000

Clinical and Experimental Dermatology

197

142

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“…[2] As sensitization to food early in life may be a predisposing factor,[3] it is important to investigate whether the elimination of dietary triggers can help alleviate the symptoms of atopic dermatitis. The role of dietary factors in atopic dermatitis—either as a causative factor or as a treatment measure through the use of exclusion diets—remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hypoallergenic Diagnostic Diet in Adolescents and Adult Patients Suffering from Atopic Dermatitis

Čelakovská¹,

Ettlerová²,

Bukač³

et al. 2012

Indian J Dermatol

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Aim:To evaluate the effect of a diagnostic hypoallergenic diet on the severity of atopic dermatitis in patients over 14 years of age.Materials and Methods:The diagnostic hypoallergenic diet was recommended to patients suffering from atopic dermatitis for a period of 3 weeks. The severity of atopic dermatitis was evaluated at the beginning and at the end of this diet (SCORAD I, SCORAD II) and the difference in the SCORAD over this period was statistically evaluated.Results:One hundred and forty-nine patients suffering from atopic dermatitis were included in the study: 108 women and 41 men. The average age of the subjects was 26.03 (SD: 9.6 years), with the ages ranging from a minimum of 14 years to a maximum of 63 years. The mean SCORAD at the beginning of the study (SCORAD I) was 32.9 points (SD: 14.1) and the mean SCORAD at the end of the diet (SCORAD II) was 25.2 points (SD: 9.99). The difference between SCORAD I and SCORAD II was evaluated with the Wilcoxon signed-rank test. The average decrease of SCORAD was 7.7 points, which was statistically significant (P=.00000).Conclusion:Introduction of the diagnostic hypoallergenic diet may serve as a temporary medical solution” in patients suffering from moderate or severe forms of atopic dermatitis. It is recommended that this diet be used in the diagnostic workup of food allergy.

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“…However, many food reactions in people with atopic eczema may not necessarily be mediated through immune reactions (5). As sensitization to food early in life may be a predisposing factor (6) it is important to investigate whether the elimination of dietary triggers could help to alleviate the symptoms of atopic eczema.…”

mentioning

confidence: 99%

“…There is a vast amount of literature claiming that dietary elimination causes improvement of atopic eczema in some cases. However, much of the evidence fails to withstand close scrutiny (5).…”

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confidence: 99%

Dietary exclusions for improving established atopic eczema in adults and children: systematic review

Bath‐Hextall

Delamere

Williams

2009

Allergy

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Atopic eczema is the most common inflammatory skin disease of childhood in developed countries. We performed a systematic review of randomized controlled trials to assess the effects of dietary exclusions for the treatment of established atopic eczema. Nine trials (421 participants) were included, most of which were poorly reported. Six were studies of egg and milk exclusion (n = 288), one was a study of few foods (n = 85) and two were studies of an elemental diet (n = 48). There appears to be no benefit of an egg‐ and milk‐free diet in unselected participants with atopic eczema. There is also no evidence of benefit in the use of an elemental or few‐foods diet in unselected cases of atopic eczema. There may be some benefit in using an egg‐free diet in infants with suspected egg allergy who have positive specific IgE to eggs – one study found 51% of the children had a significant improvement in body surface area with the exclusion diet as compared with normal diet (95% CI 1.07–2.11) and change in surface area and severity score was significantly improved in the exclusion diet as compared with the normal diet at the end of 6 weeks (MD 5.50, 95% CI 0.19–10.81) and end of treatment (MD 6.10, 95% CI 0.06–12.14). Despite their frequent use, we find little good quality evidence to support the use of exclusion diets in atopic eczema.

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Dietary factors in established atopic dermatitis

Cited by 7 publications

References 0 publications

Epidemiology of atopic dermatitis

Epidemiology of atopic dermatitis

The Effect of Hypoallergenic Diagnostic Diet in Adolescents and Adult Patients Suffering from Atopic Dermatitis

Dietary exclusions for improving established atopic eczema in adults and children: systematic review

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