2024
DOI: 10.1186/s40035-024-00406-z
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Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Russell G. Wells,
Lee E. Neilson,
Andrew W. McHill
et al.

Abstract: Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a CAG repeat expansion in the huntingtin gene HTT. HD is characterized by a variety of debilitating symptoms including involuntary movements, cognitive impairment, and psychiatric disturbances. Despite considerable efforts, effective disease-modifying treatments for HD remain elusive, necessitating exploration of novel therapeutic approaches, including lifestyle mo… Show more

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