Dietary Fat and Fish Intake and Age-Related Maculopathy

Smith, Wayne

doi:10.1001/archopht.118.3.401

Cited by 188 publications

(115 citation statements)

References 36 publications

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“…Foods that mainly contributed to the risk of AMD were beef, pork, and lamb; in particular, total fat and α-linolenic acid were risk factors. In contrast, DHA intake showed a modest inverse correlation with AMD risk, confirming the previously reported beneficial actions of fish intake [70]. In the same year, conflicting results were reported.…”

Section: Omega-3 and Omega-6 Pufasupporting

confidence: 76%

“…Smith et al [70] reported a borderline significant increase in the risk for late AMD in association with high levels of dietary cholesterol intake [70], thus confirming results reported by Mares-Perlman et al [83]. Similarly, the AREDS study described an increased likelihood of developing AMD with an increased cholesterol intake [73].…”

Section: Cholesterolsupporting

confidence: 53%

“…Subsequently, Smith et al reported only a borderline significant association between SFA intake and the risk for early AMD [70]. Similarly, Cho et al described a modest increase in the risk of AMD for subjects with a high dietary intake of saturated fats [69].…”

Section: 3mentioning

confidence: 99%

“…Previous studies have reported inverse association between MUFA and AMD risk. In particular, Smith et al reported that a high dietary intake of MUFA was a risk factor for early AMD [70], and Parekh et al demonstrated that it was a protective factor for intermediate AMD [76]. A potential explanation of these contrasting results was reported by the AREDS study group.…”

Section: 2mentioning

confidence: 99%

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Review of nutrient actions on age-related macular degeneration

Zampatti¹,

Ricci²,

Cusumano³

et al. 2014

Nutrition Research

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The actions of nutrients and related compounds on age-related macular degeneration however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression.

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Section: Omega-3 and Omega-6 Pufasupporting

confidence: 76%

Section: Cholesterolsupporting

confidence: 53%

Section: 3mentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

See 2 more Smart Citations

Review of nutrient actions on age-related macular degeneration

Zampatti¹,

Ricci²,

Cusumano³

et al. 2014

Nutrition Research

View full text Add to dashboard Cite

show abstract

“…Few epidemiological studies are available concerning the associations of AMD with fat. In two cross-sectional studies [25,26], weekly fish consumption, which is the main source of DHA, was associated with a 50 to 60 % reduction in risk for AMD, after multivariate adjustment. In the Eye Disease Case Control Study, a high dietary intake of 6 PUFA was significantly associated with a 2 fold increased risk for exsudative AMD, after multivariate adjustment.…”

mentioning

confidence: 99%

Application of Nutrigenomics in Eye Health

Delcourt¹

2007

Nutrigenomics - Opportunities in Asia

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Murine High-Fat Diet and Laser Photochemical Model of Basal Deposits in Bruch Membrane

Dithmar

Sharara²,

Curcio³

et al. 2001

Arch Ophthalmol

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To examine the histologic, histochemical, and ultrastructural changes in Bruch membrane in mice on a high-fat diet with and without laser photochemical injury. Methods: Five groups of C57BL/6 mice were studied. Group 1 included 2-month-old mice on a normal diet; group 2 included 8-month-old mice on a normal diet; group 3 included 8-month-old mice on a high-fat diet; groups 4 and 5 included 8-month-old mice on a normal diet or highfat diet, respectively, that underwent laser application of one eye with argon blue laser (488 nm). The mice were killed and plasma lipid levels were measured. The eyes were examined by standard electron microscopy, filipin histochemistry for unesterified cholesterol (UC) and esterified cholesterol (EC), and the osmium-tannic acidphenylenediamine method for preserving extracellular lipid particles. Results: The plasma cholesterol level was significantly higher in the mice on the high-fat diet than the controls (PϽ.001). Bruch membrane was thicker in group 2 than group 1 (P=.04) and group 3 had a thicker Bruch membrane than group 2 (P=.003). All eyes in group 3 exhibited accumulation of electron-lucent debris. There was no histochemical and ultrastructural evidence that this material represented accumulated UC or EC. Seven of 9 laserinjured eyes in group 5 accumulated basal laminar deposit (BlamD)-like material in Bruch membrane (P=.02). Conclusions: Electron-lucent debris accumulates in murine Bruch membrane, and the amount correlates with age and high-fat diet. This debris has some similarities with basal linear deposits, although the debris does not form a discrete layer external to the basement membrane of the retinal pigment epithelium as occurs in basal linear deposits. These deposits do not appear to be UC or EC. Laser photochemical injury of the retinal pigment epithelium may result in the appearance of BlamDlike deposits in eyes with electron-lucent debris. The BlamD-like deposits in this model are similar to the basal laminar deposits that occur in age-related macular degeneration. Clinical Relevance: This is an animal model of ultrastructural BlamD-like material in Bruch membrane that is very similar to the deposits that occur in age-related macular degeneration.

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Dietary Fat and Fish Intake and Age-Related Maculopathy

Cited by 188 publications

References 36 publications

Review of nutrient actions on age-related macular degeneration

Review of nutrient actions on age-related macular degeneration

Application of Nutrigenomics in Eye Health

Murine High-Fat Diet and Laser Photochemical Model of Basal Deposits in Bruch Membrane

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