Dietary Fat Influences the Expression of Genes Related to Sterol Metabolism and the Composition of Cecal Microbiota and Its Metabolites in Rats

Abstract

IntroductionThe human intestinal tract harbors trillions of bacteria referred to as the gut microbiota, which play an important role in digestion and host metabolism 1 . The change in the composition of gut microbiota has been implicated in the development of metabolic diseases, including type-2 diabetes and obesity 2 . The composition of gut microbiota is influenced by the intestinal environment, including the type of food digested by the host, digestive fluid volume, and digestive fluid quality 3 . Numerous studies have evaluated the composition of gut microbiota and its metabolites in experimental animals fed high-fat or low-fiber diets 4, 5 . However, few reports have focused on the effects of different types of dietary fat sources on gut microbiota and its

Dietary Alaska pollock protein alters insulin sensitivity and gut microbiota composition in rats

“…Compared with the amino acid composition of casein, APP is rich in alanine, arginine, aspartic acid (aspartic acid + asparagine), and glycine, whereas poor in glutamic acid (glutamic acid + glutamine) and proline. The intake of n ‐3 PUFA prevents insulin resistance and alters the gut microbiota composition in rats (Hosomi et al., 2019; Robbez Masson et al., 2008). Therefore, contamination of EPA and DHA in APP were tested.…”

Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A

“…Chronic consumption of HFD induces overweight along with metabolic and cardiovascular alterations, such as insulin resistance, dyslipidemia or hypertension, among others, being all of these symptoms of the MtS [3,4]. Interestingly, studies in animal models demonstrated that HFD intake is related to gut dysbiosis [29,30]. Gut dysbiosis can develop as early as 2 weeks on HFD, long before the development of MtS-related symptoms [31].…”

Effects of dietary oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) on cholesterol metabolism in obese type‐II diabetic KK‐Ay mice

“…Conversely, the liver Abcg5/8 expression levels of the TO group were significantly increased, compared to those of the Control group. Our previous study demonstrated that the dietary TO significantly increased the liver Abcg5/8 expression levels compared to the dietary menhaden oil which is rich in EPA (Hosomi et al, 2019), in rats. Therefore, the dietary DHA was expected to increase cholesterol excretion from the liver to bile by increasing the liver Abcg5/8 expression levels.…”