Dietary fat intake and risk of Parkinson's disease: A case-control study in Japan

Miyake, Yoshihiro; Sasaki, Satoshi; Tanaka, Keiko; Fukushima, Wakaba; Kiyohara, Chikako; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Miki, T.; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki

doi:10.1016/j.jns.2009.09.021

Cited by 90 publications

(94 citation statements)

References 43 publications

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“…Finally, 21 eligible articles that reported 4438 cases (263 cases of MCI, 320 cases of cognitive decline, 1864 cases of dementia, 1332 cases of AD, and 659 cases of PD) in 181,580 participants from 17 independent cohorts were included (9-13, 24, 44-58). Of these articles, 4 case-control studies were included (50,(53)(54)(55). Table 1 and Supplemental Table 1 show the characteristics of included studies.…”

Section: Methodsmentioning

confidence: 99%

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Zhang

Chen

Qiu³

et al. 2016

The American Journal of Clinical Nutrition

272

183

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Background: The intake of fish and polyunsaturated fatty acids (PUFAs) may benefit cognitive function. However, optimal intake recommendations for protection are unknown. Objective: We systematically investigated associations between fish and PUFA intake and mild-to-severe cognitive impairment risk. Design: Studies that reported risk estimates for mild cognitive impairment (MCI), cognitive decline, dementia, Alzheimer disease (AD), or Parkinson disease (PD) from fish, total PUFAs, total n-3 (v-3) PUFAs, or at least one n-3 PUFA were included. Study characteristics and outcomes were extracted. The pooled RR was estimated with the use of a random-effects model metaanalysis. A dose-response analysis was conducted with the use of the 2-stage generalized least-squares trend program. Results: We included 21 studies (181,580 participants) with 4438 cases identified during follow-up periods (2.1-21 y). A 1-serving/wk increment of dietary fish was associated with lower risks of dementia (RR: 0.95; 95% CI: 0.90, 0.99; P = 0.042, I 2 = 63.4%) and AD (RR: 0.93; 95% CI: 0.90, 0.95; P = 0.003, I 2 = 74.8%). Pooled RRs of MCI and PD were 0.71 (95% CI: 0.59, 0.82; P = 0.733, I 2 = 0%) and 0.90 (95% CI: 0.80, 0.99; P = 0.221, I 2 = 33.7%), respectively, for an 8-g/d increment of PUFA intake. As an important source of marine n-3 PUFAs, a 0.1-g/d increment of dietary docosahexaenoic acid (DHA) intake was associated with lower risks of dementia (RR: 0.86; 95% CI: 0.76, 0.96; P , 0.001, I 2 = 92.7%) and AD (RR: 0.63; 95% CI: 0.51, 0.76; P , 0.001, I 2 = 94.5%). Significant curvilinear relations between fish consumption and risk of AD and between total PUFAs and risk of MCI (both P-nonlinearity , 0.001) were observed. Conclusions: Fishery products are recommended as dietary sources and are associated with lower risk of cognitive impairment. Marinederived DHA was associated with lower risk of dementia and AD but without a linear dose-response relation.Am J Clin Nutr 2016;103:330-40.

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Section: Methodsmentioning

confidence: 99%

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Zhang

Chen

Qiu³

et al. 2016

The American Journal of Clinical Nutrition

272

183

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“…Here, we examined the association between dietary intake of folate, vitamin B 6 , vitamin B 12 and riboflavin and the risk of PD using data from a multicentre hospitalbased case -control study in Japan (9,10) . Population-specific genetic characteristics (e.g.…”

mentioning

confidence: 99%

Dietary intake of folate, vitamin B₆, vitamin B₁₂ and riboflavin and risk of Parkinson's disease: a case–control study in Japan

et al. 2010

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Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case -control study in Japan to examine associations between dietary intake of folate, vitamin B 6 , vitamin B 12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B 12 and riboflavin was not associated with the risk of PD (P for trend¼0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B 6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B 6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend¼ 0·10). In conclusion, in the present case -control study in Japan, low intake of vitamin B 6 , but not of folate, vitamin B 12 or riboflavin, was independently associated with an increased risk of PD.

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“…Emerging epidemiological evidence lends some support to this. In particular, increased dietary intake of omega-3 polyunsaturated FAs (n-3 PUFAs) has been associated with a decreased risk of PD (16), while increased PD risk has been associated with a high intake of the n-6 PUFA arachidonic acid (21). Dietary n-3 PUFAs also provide neuroprotection in toxin-induced rodent models of parkinsonism (16).…”

Section: Fas and Pdmentioning

confidence: 99%

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

Abumrad

Moore²

2011

J. Clin. Invest.

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Dietary fat intake and risk of Parkinson's disease: A case-control study in Japan

Cited by 90 publications

References 43 publications

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Dietary intake of folate, vitamin B₆, vitamin B₁₂ and riboflavin and risk of Parkinson's disease: a case–control study in Japan

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

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Dietary fat intake and risk of Parkinson's disease: A case-control study in Japan

Cited by 90 publications

References 43 publications

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

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Dietary intake of folate, vitamin B₆, vitamin B₁₂ and riboflavin and risk of Parkinson's disease: a case–control study in Japan