Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

Labayen, Idoia; Ruiz, Jonatan R.; Huybrechts, Inge; Ortega, Francisco B.; Arenaza, Lide; González‐Gross, Marcela; Widhalm, Kurt; Molnár, Denés; Μanios, Yannis; DeHenauw, Stefaan; Meirhaeghe, Aline; Moreno, Luís A.

doi:10.1016/j.numecd.2016.07.010

Cited by 27 publications

(19 citation statements)

References 38 publications

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“…A mechanistic explanation for the positive response of carriers of the FTO risk allele to behavioral modification is not clear, yet may be related to greater reduction of the brain's reward activation to food as a response to weight loss . In addition, it has been demonstrated that an FTO gene‐environment interaction in subjects who are physically active and/or have a low intake of fat results in a marked reduction of the obesogenic effect of the FTO AA gene variant . As both reduced fat intake and increased physical activity are central parts in most behavioral interventions, it is possible that in individuals with obesity, partly because of FTO, response is better to such interventions.…”

Section: Discussionmentioning

confidence: 99%

“…35 In addition, it has been demonstrated that an FTO gene-environment interaction in subjects who are physically active and/or have a low intake of fat results in a marked reduction of the obesogenic effect of the FTO AA gene variant. 36 As both reduced fat intake and increased physical activity are central parts in most behavioral interventions, it is possible that in individuals with obesity, partly because of FTO, response is better to such interventions. Hence, in the long-term, FTO genetic predisposition to obesity may result in a cycle of weight loss and regain.…”

Section: Discussionmentioning

confidence: 99%

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Predictors of responses to clinic‐based childhood obesity care

Hagman

Hecht²,

et al. 2018

Pediatr Diabetes

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predictors of responses to clinic‐based childhood obesity care

Hagman

Hecht²,

et al. 2018

Pediatr Diabetes

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“…Cecil et al [23] observed that children with the A allele have a preference for energy-dense food. In contrast, Labayen et al [24] showed that the FTO rs9939609 was not significantly associated with energy intake, but rather with the effect of the A allele on adiposity, which increased proportionally to the dietary fat content.…”

Section: Discussionmentioning

confidence: 88%

The significance of the FTO gene on weight gain and body composition in young Swedish women with severe anorexia nervosa: a three-year follow-up study

Svedlund¹,

Tubić

Elfvin

et al. 2020

Preprint

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Background: The aim of this prospective study was to investigate the potential influence of the fat mass and obesity-associated gene (FTO), SNP rs9939609, on body mass index (BMI) and body composition in women with severe anorexia nervosa during intensive nutrition therapy and after three years. Methods: Twenty-five female anorexia nervosa patients (age 20.1±2.3 years, BMI 15.5±1.0 kg/m2) were treated for 12 weeks with a high-energy diet. FTO was genotyped and body composition parameters were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography at baseline, after 12 weeks and at three-year follow-up. Results: Patients gained, on average, 9.9 kg and BMI increased to 19.0±0.9 kg/m2 during intensive nutrition therapy. Fat mass increased, p<0.001, but total lean mass was stable. After three years, BMI remained stable, 19.4±3.3 kg/m2, as well as fat mass parameters and total lean mass. Muscle density decreased while the quotient fat/muscle area increased during nutrition therapy, but both then stabilized and remained stable after three years. There were no associations between FTO genotype and BMI or body composition parameters during the nutrition therapy or after three years. A tendency towards more stable BMI was observed in patients with the TT genotype and wider range in BMI for patients with the risk allele A after three years. Conclusions: Irrespective of the FTO genotype, there was no difference in weight response during nutrition therapy, or at three-year follow-up. Hence, there is limited support for individualized therapy for anorexia nervosa based on FTO genotype. Trial registration: Current Controlled Trials ISRCTN76310580. Date of registration: 15/01/2020. Retrospectively registered.

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“…Fat intake may modifiy the effect of the FTO rs9939609 polymorphism on adiposity. It was observed that carriers of the A risk allele FTO rs9939609 had no significant influence on adiposity in subjects whose dietary fat intake was below 30% of total energy but fat intake higher than 30% increased central and total adipose tissues (20).…”

Section: Discussionmentioning

confidence: 99%

The association between FTO genotype and macro-nutrients’ intake in overweight adults

Mehrdad

Doaei

Eftekhari

2019

Preprint

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Background Macro-nutrients can influence on body weight through their interactions with FTO gene polymorphisms. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macro-nutrients intake.Methods This cross-sectional study was carried out on 196 overweight adults. The rs9939609 SNP in FTO was genotyped. Dietary intake was assessed by a valid 168-item semi-quantitative food frequency questionnaire (FFQ). The association between dietary macro-nutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL).Results The higher carbohydrates (p=0.000), fat intake (p=0.009) and calorie intake (p=0.001) were significantly associated with FTO gene risk allele (P=0.001). Carriers of the AA/AG genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype (p=0.019, p=0.010, & p=0.000, respectively).Conclusion The dietary carbohydrate and fat intake were associated with FTO genotype. Further studies are warranted to investigation of these interactions and the underlying mechanisms.

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Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

Cited by 27 publications

References 38 publications

Predictors of responses to clinic‐based childhood obesity care

Predictors of responses to clinic‐based childhood obesity care

The significance of the FTO gene on weight gain and body composition in young Swedish women with severe anorexia nervosa: a three-year follow-up study

The association between FTO genotype and macro-nutrients’ intake in overweight adults

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