Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome

López-Moreno, Javier; Quintana-Navarro, Gracia M.; Camargo, Antonio; Jiménez-Lucena, Rosa; Delgado-Lista, Javier; Marı́n, Carmen; Tinahones, Francisco J.; Striker, Gary E.; Roche, Helen M.; Pérez‐Martínez, Pablo; López‐Miranda, José; Yubero‐Serrano, Elena M.

doi:10.1002/mnfr.201601029

Cited by 37 publications

(27 citation statements)

References 56 publications

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“…In overweight and obese subjects, when compared to the low‐fat high‐AGE diet group, consumption of a single high‐fat high‐AGE breakfast showed a different response pattern in serum CML, secreted RAGE and total cholesterol (Davis et al., 2015). Likewise, in comparison to the low‐fat high‐complex carbohydrate group, low‐AGE high‐monounsaturated fatty acids diets reduced the serum content of AGEs and RAGE expression while enhanced the AGR‐R1 and Gloxl mRNA levels in patients with metabolic syndrome (Lopez‐Moreno et al., 2017). By contrast, in an observation study enrolling patients with renal failure, no correlations between serum CML level and macronutrient intake, that is, protein, fat, saturated fat, and carbohydrate, were demonstrated (Uribarri, Peppa, Cai, Goldberg, Lu, Baliga, et al., 2003).…”

Section: Health Implications Of Dages: Perspectives To Fill the Gap Bmentioning

confidence: 99%

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang

2020

Comp Rev Food Sci Food Safe

144

116

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Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods.

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Section: Health Implications Of Dages: Perspectives To Fill the Gap Bmentioning

confidence: 99%

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang

2020

Comp Rev Food Sci Food Safe

144

116

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“…Specific to diet‐induced inflammation, plasma levels of RAGE ligands increase with high saturated‐fat diets (Lopez‐Moreno et al. ) and in mice, RAGE is critical in mediating inflammation and insulin resistance in response to high‐fat feeding (Song et al. ).…”

Section: Introductionmentioning

confidence: 99%

A single high-fat meal alters human soluble RAGE profiles and PBMC RAGE expression with no effect of prior aerobic exercise

et al. 2018

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A high‐fat diet can induce inflammation and metabolic diseases such as diabetes and atherosclerosis. The receptor for advanced glycation endproducts (RAGE) plays a critical role in metabolic disease pathophysiology and the soluble form of the receptor (sRAGE) can mitigate these effects. However, little is known about RAGE in the postprandial condition and the effect of exercise in this context. Thus, we aimed to determine the effects of a single high‐fat meal (HFM) with and without prior exercise on peripheral blood mononuclear cell (PBMC) RAGE biology. Healthy males (n = 12) consumed a HFM on two occasions, one without prior exercise and one 16–18 hours following acute aerobic exercise. Total soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE) were determined via ELISA and cleaved RAGE (cRAGE) was calculated as the difference between the two. Isolated PBMCs were analyzed for RAGE, ADAM10, TLR4, and MyD88 protein expression and ADAM10 activity. The HFM significantly (P < 0.01) attenuated sRAGE, esRAGE, and cRAGE by 9.7%, 6.9%, and 10.5%, respectively. Whereas, the HFM increased PBMC RAGE protein expression by 10.3% (P < 0.01), there was no meal effect on PBMC TLR4, MYD88, or ADAM10 protein expression, nor ADAM10 activity. There was also no exercise effect on any experimental outcomes. These findings suggest that PBMC RAGE and soluble RAGE may be important in the postprandial response to a HFM, and that prior aerobic exercise does not alter these processes in young healthy adult males. The mechanisms by which a HFM induces RAGE expression and reduces circulating soluble RAGE isoforms requires further study.

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“…Conversely, low-AGE diets were shown to reverse insulin resistance and chronic inflammation, inhibit the progression of atherosclerosis and prevent experimental diabetic complications [35,36]. In this context, we have recently published that, in both elderly adults and patients with the metabolic syndrome, a Mediterranean diet could be a beneficial dietary model in terms of AGEs reduction as it has a low content of dietary AGEs, thus consequently reducing their circulating levels and the degree of oxidative stress and inflammation [37,38].…”

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study

et al. 2020

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Endothelial dysfunction and intima-media thickness of common carotid arteries (IMT-CC) are considered subclinical markers of atherosclerotic cardiovascular disease (ASCVD). Advanced glycation end products (AGEs) are increased in type 2 diabetes mellitus (T2DM) patients, compared with non-diabetics, being implicated in micro- and macrovascular complications. Our aim was to compare serum AGEs levels and subclinical atherosclerotic markers between patients with established and newly diagnosed T2DM. Among 540 patients with T2DM and coronary heart disease from the CORDIOPREV study, 350 patients had established T2DM and 190 patients had newly diagnosed T2DM. Serum levels of AGEs (methylglyoxal (MG) and N-carboxymethyl lysine (CML)) and subclinical atherosclerotic markers (brachial flow-mediated vasodilation (FMD) and IMT-CC) were measured. AGEs levels (all p < 0.001) and IMT-CC (p = 0.025) were higher in patients with established vs. newly diagnosed T2DM, whereas FMD did not differ between the two groups. Patients with established T2DM and severe endothelial dysfunction (i.e., FMD < 2%) had higher serum MG levels, IMT-CC, HOMA-IR and fasting insulin levels than those with newly diagnosed T2DM and non-severe endothelial dysfunction (i.e., FMD ≥ 2%) (all p < 0.05). Serum CML levels were greater in patients with established vs. newly diagnosed T2DM, regardless of endothelial dysfunction severity. Serum AGEs levels and IMT-CC were significantly higher in patients with established vs. newly diagnosed T2DM, highlighting the progressively increased risk of ASCVD in the course of T2DM. Establishing therapeutic strategies to reduce AGEs production and delay the onset of cardiovascular complications in newly diagnosed T2DM patients or minimize ASCVD risk in established T2DM patients is needed.

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Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome

Abstract: Low AGE content in HMUFA diet reduces sAGEs and modulates the gene expression related to AGE metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.

Cited by 37 publications

References 56 publications

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

A single high-fat meal alters human soluble RAGE profiles and PBMC RAGE expression with no effect of prior aerobic exercise

Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study

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