Dietary fat saturation produces lipid modifications in peritoneal macrophages of mouse

Oliveros, Liliana; Videla, Andrea Mónica; Ramirez, Dario C.; Giménez, María Sofía

doi:10.1016/s0955-2863(03)00057-3

Cited by 12 publications

(8 citation statements)

References 35 publications

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“…The proportion of MUFA in pequi oil did not appear to be adequate to counteract the effects of SFA on blood lipids. Regarding soybean oil composition, our results agree with other studies demonstrating that it is composed of approximately 15% SFA, 20% MUFA, and more than 40% of the PUFA linoleic acid (18:2 ω-6) (21-24). Therefore, although pequi oil has more than 50% PUFA in its composition, the high proportion of SFA gives the pequi oil a fatty acid distribution that is more atherogenic than soybean oil, resulting in the hypercholesterolemia seen in the pequi oil diet group.…”

Section: Discussionsupporting

confidence: 91%

Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Aguilar

Jascolka

Teixeira

et al. 2012

Braz J Med Biol Res

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Pequi is the fruit of Caryocar brasiliense and its oil has a high concentration of monounsaturated and saturated fatty acids, which are anti- and pro-atherogenic agents, respectively, and of carotenoids, which give it antioxidant properties. Our objective was to study the effect of the intake of a cholesterol-rich diet supplemented with pequi oil, compared to the same diet containing soybean oil, on atherosclerosis development, and oxidative stress in atherosclerosis-susceptible LDL receptor-deficient mice (LDLr−/−, C57BL/6-background). Female mice were fed a cholesterol-rich diet containing 7% soybean oil (Soybean group, N = 12) or 7% pequi oil (Pequi group, N = 12) for 6 weeks. The Pequi group presented a more atherogenic lipid profile and more advanced atherosclerotic lesions in the aortic root compared to the Soybean group. However, the Pequi group presented a less advanced lesion in the aorta than the Soybean group and showed lower lipid peroxidation (Soybean group: 50.2 ± 7.1; Pequi group: 30.0 ± 4.8 µmol MDA/mg protein) and anti-oxidized LDL autoantibodies (Soybean group: 35.7 ± 9.4; Pequi group: 15.6 ± 3.7 arbitrary units). Peritoneal macrophages from the Pequi group stimulated with zymosan showed a reduction in the release of reactive oxygen species compared to the Soybean group. Our data suggest that a pequi oil-rich diet slows atherogenesis in the initial stages, possibly due to its antioxidant activity. However, the increase of serum cholesterol induces a more prominent LDL migration toward the intimae of arteries, increasing the advanced atherosclerotic plaque. In conclusion, pequi oil associated with an atherogenic diet worsens the lipid profile and accelerates the formation of advanced atherosclerotic lesions despite its antioxidant action.

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Section: Discussionsupporting

confidence: 91%

Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Aguilar

Jascolka

Teixeira

et al. 2012

Braz J Med Biol Res

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“…Several studies of animals have reported that the consumption of coconut oil enhanced lipogenesis in liver, which was also reflected in increased TG and cholesterol levels in plasma (19,20). In our present study, mice were fed a coconut oil-supplemented diet (without extra cholesterol supplementation) for 4 wk, and these mice exhibited hypotriglyceridemia and hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 64%

Effect of five cysteine‐containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet

Lin

Yin

Hsu

et al. 2004

Lipids

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The in vivo effects of N-acetyl cysteine (NAC), S-allyl cysteine, S-ethyl cysteine (SEC), S-methyl cysteine (SMC), and S-propyl cysteine (SPC) against hyperlipidemia development and oxidation stress in Balb/cA mice consuming a high saturated fat diet were examined. The influence of these agents on plasma levels of glucose, insulin, uric acid, TG, cholesterol, and the activity of three lipogenic enzymes--glucose-6-phosphate dehydrogenase, malic enzyme, and FA synthase--was determined. All mice consumed the coconut oil-basd, high saturated fat diet, water, and cysteine or one of the five cysteine-containing compounds for 4 wk. The diet with 18% saturated fat significantly elevated the activity of three lipogenic enzymes and significantly increased TG and cholesterol biosynthesis in plasma and liver (P < 0.05). When compared with the water and cysteine groups, the treatments from five cysteine-containing agents significantly reduced high saturated fat diet-increased malic enzyme and FA synthase activities, and significantly lowered TG levels in plasma and liver (P< 0.05); however, only NAC, SAC, and SMC treatments significantly reduced cholesterol levels in plasma and liver (P < 0.05). The five cysteine-containing agents significantly restored high saturated fat diet-decreased glutathione peroxidase (GPX) activity in liver (P< 0.05); however, only SMC and SPC significantly restored GPX activity in heart and kidney (P< 0.05). These agents also significantly improved high saturated fat diet-related hyperglycemia, hyperuricemia, and oxidation stress (P < 0.05). These data support the hypothesis that these compounds are potential multiply-protective agents for hyperlipidemia prevention or therapy.

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“…Rats fed a diet enriched in 20:5n-3 did not have altered EtnGpl and ChoGpl masses in the erythrocytes (67). On the other hand, a soybean oil-enriched diet increased the ChoGpl and decreased the EtnGpl content in macrophages (68). In addition, the liver and heart CerPCho masses were increased in the fish oil group as compared with the other two groups.…”

Section: Discussionmentioning

confidence: 89%

Dietary α‐linolenic acid increases brain but not heart and liver docosahexaenoic acid levels

Barceló‐Coblijn

Collison

Jolly

et al. 2005

Lipids

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Fish oil-enriched diets increase n-3 FA in tissue phospholipids; however, a similar effect by plant-derived n-3 FA is poorly defined. To address this question, we determined mass changes in phospholipid FA, individual phospholipid classes, and cholesterol in the liver, heart, and brain of rats fed diets enriched in flax oil (rich in 18:3n-3), fish oil (rich in 22:6n-3 and 20:5n-3), or safflower oil (rich in 18:2n-6) for 8 wk. In the heart and liver phospholipids, 22:6n-3 levels increased only in the fish oil group, although rats fed flax oil accumulated 20:5n-3 and 22:5n-3. However, in the brain, the flax and fish oil diets increased the phospholipid 22:6n-3 mass. In all tissues, these diets decreased the 20:4n-6 mass, although the effect was more marked in the fish oil than in the flax oil group. Although these data do not provide direct evidence for 18:3n-3 elongation and desaturation by the brain, they demonstrate that 18:3n-3-enriched diets reduced tissue 20:4n-6 levels and increased cellular n-3 levels in a tissue-dependent manner. We hypothesize, based on the lack of increased 22:6n-3 but increased 18:3n-3 in the liver and heart, that the flax oil diet increased circulating 18:3n-3, thereby presenting tissue with this EFA for further elongation and desaturation.

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Dietary fat saturation produces lipid modifications in peritoneal macrophages of mouse

Cited by 12 publications

References 35 publications

Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Effect of five cysteine‐containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet

Dietary α‐linolenic acid increases brain but not heart and liver docosahexaenoic acid levels

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