Dietary fats influence consumption and metabolic measures in male and female laboratory mice

Abstract

SummaryJuvenile and adult male and female Swiss mice in metabolism cages were fed one of four specially-formulated, pelleted diets containing respectively 8% saturated vegetable fat, 8% soya oil, 8% olive oil and 2 % soya oil. The identities of the diets were hidden from the experimenter. Subjects were individually housed in metabolism cages and their consumption of food, growth and eliminative activities were measured. Clearly, these non-isocaloric diets differed in palatability, producing complex effects on growth as well as metabolic measures. Many indices were influenced by age, sex, and the duration of dietary exposure. Interactions between factors were common. Dietary fats appear to have subtle effects on the physiology and behaviour of rodents and may account for some differences between studies.

Dietary fats influence 'open-field' behaviour of male and female laboratory mice

“…The modest body weight gain in these subjects may be due to the low-fat content of that diet (which would reduce its calori c content). Other studies on the same mice (Brain et al 2000) have shown that these non-isocalori c diets differed in palatability, producing complex effects on growth as well as metabolic measures. Many of these physiological indices were in uenced by age, sex and duration of dietary exposure.…”

“…Consequently, the mice in the present study could 'self dose' themselves with different quantities of the varied diets on the basis of their preferences. These preferences might be in uenced by age, sex and duration of exposure (Brain et al 2000).…”