Dietary fatty acids sex-specifically modulate guinea pig postnatal development via cortisol concentrations

Nemeth, Matthias; Millesi, Eva; Schuster, Daniela; Quint, Ruth; Wagner, Karl‐Heinz; Wallner, Bernard

doi:10.1038/s41598-017-18978-4

Cited by 5 publications

(2 citation statements)

References 61 publications

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“…Indeed, they can diminish glucocorticoid secretion through the modulation of the hypothalamicpituitary-adrenal (HPA) axis, thus resulting in a positive influence on structural growth rates. 67,68 On the contrary, an excess of dietary n-6 PUFA has shown a stimulation of adipogenesis and the development of adipose tissue in mice. 69 In our previous study, 23 Italian Duroc piglets had a higher body weight compared to Italian Landrace and Italian Large White piglets at day 3 after birth.…”

Section: ■ Discussionmentioning

confidence: 99%

Evaluation of Breed and Parity Order Effects on the Lipid Composition of Porcine Colostrum

Luise

Cardenia

Zappaterra

et al. 2018

J. Agric. Food Chem.

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Porcine colostrum lipid classes and fatty acids (FA) were characterized in 6 pools (from 69 samples) from 3 sow breeds (Italian Large White, Italian Landrace, and Italian Duroc) and different parity orders (only Large White). Triacylglycerols (TAG; 94.44 expressed as g/100 g of fat) were the most abundant lipid class, followed by diacylglycerols (DAG; 3.36 g/100 g of fat), free fatty acids (FFA; 0.98 g/100 g of fat), and cholesterol (0.84 g/100 g of fat). The main FAs found in swine colostrum were palmitic (27.29%, expressed as g/100 g of total FA), oleic (28.81%), and linoleic (23.39%) acids. Both the breed of sow and parity order affected the FA and lipid composition. The results suggest that the FA composition of swine colostrum is similar to that of human colostrum and could represent a new source of nutrients for human infants, after further assessment of hygienic and quality aspects. The swine model could be an opportunity for a better understanding of colostrum effects on newborns.

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Section: ■ Discussionmentioning

confidence: 99%

Evaluation of Breed and Parity Order Effects on the Lipid Composition of Porcine Colostrum

Luise

Cardenia

Zappaterra

et al. 2018

J. Agric. Food Chem.

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“…Increasing PGF2 is usually regarded as an important phase in the labor procedure (17). Previous research has revealed that dietary polyunsaturated fatty acids (PUFAs) may also affect steroid hormone levels (18,19).…”

Section: Discussionmentioning

confidence: 99%

Effects of Misoprostol and Evening Primrose Extracts on Cervix Preparation for Labor Induction in Term Pregnancies

Moghimipour

Zargarzadeh

Ghaemi

et al. 2022

Fertil Gynecol Androl

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Background: Ripening is the process of preparing the cervix for induction of labor and is crucial to identify a low-complication, low-cost, and safe method of inducing labor before spontaneous labor begins. Therefore, this study aimed to demonstrate the impact of the evening primrose capsule on inducing labor, as well as to compare its effect to that of misoprostol. Methods: This prospective clinical trial study was performed on 200 low-risk pregnant women candidate for delivery in an academic hospital in Tehran from 2018 to 2020. Patients were randomly divided into two groups to receive 25 µg misoprostol vaginally or 500 mg evening primrose vaginal capsule to induce labor and repeated every three hours until reaching the bishop score > 4 in case of no effective up to three doses. The total drug dose, as well as maternal and neonatal outcomes evaluated and compared between groups. Results: Although misoprostol was significantly more effective than evening primrose in increasing cervical bishop score in the inactive phase of labor, the active phase and delivery time were not different between the groups. Also, there was no significant difference between the two groups in the cesarean section rate. Maternal complications, including uterine hyperstimulation, headache, or gastrointestinal complications in the group receiving misoprostol were significantly higher in misoprostol group, but fetal complications, including Apgar score, pH, hospitalization, and meconium excretion, were not significantly different between the two groups. Conclusions: Evening primrose capsules are safe and can be used to induce labor because of the lower risk of hyperstimulation of the uterus and the higher tolerance. There should be more research done to see if this medicine can be used alone or in conjunction with misoprostol or mechanical dilators or if it can be administered at home rather than in the hospital.

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Metabolic rate and saliva cortisol concentrations in socially housed adolescent guinea pigs

Nemeth,

Fritscher,

Füreder

et al. 2024

J Comp Physiol B

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An individual’s energetic demands and hence metabolic rate can strongly change during adolescence, a phase characterized by profound morphological, physiological, and endocrine changes. Glucocorticoid hormones (e.g. cortisol) are released in response to hypothalamic–pituitary–adrenal–axis activity, modulate several metabolic processes, and can also be linked to increased metabolic rate. In domestic guinea pigs (Cavia aperea f. porcellus) housed in same-sex groups, cortisol concentrations increase during adolescence in males but remain stable in females, which was suggested to be related to different energetic demands by age. We therefore measured metabolic rate through oxygen (O2) consumption over 2.5 h in male and female guinea pigs housed in same-sex groups during adolescence at ages of 60, 120, and 180 days, which was paralleled by analyses of saliva cortisol concentrations before and after the measurement. The statistical analyses involved whole body metabolic rate (ml O2/h), body mass-corrected metabolic rate (ml O2/h/kg), and body mass-independent metabolic rate (ml O2/h statistically corrected for body mass). We found increasing cortisol concentrations with age in males only, but none of the three metabolic rate analyses revealed a sex difference by age. On the individual level, repeatability across ages was found in metabolic rate as well as in body mass and cortisol concentrations after the measurement, but not in “basal” cortisol concentrations. Our results suggest no sex-specific changes in metabolic rate and hence equal energetic demands in male and female guinea pigs during adolescence. Moreover, metabolic rate clearly represents a highly stable physiological trait already early in a guinea pig’s life irrespective of rather fluctuating cortisol concentrations.

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Dietary fatty acids sex-specifically modulate guinea pig postnatal development via cortisol concentrations

Cited by 5 publications

References 61 publications

Evaluation of Breed and Parity Order Effects on the Lipid Composition of Porcine Colostrum

Evaluation of Breed and Parity Order Effects on the Lipid Composition of Porcine Colostrum

Effects of Misoprostol and Evening Primrose Extracts on Cervix Preparation for Labor Induction in Term Pregnancies

Metabolic rate and saliva cortisol concentrations in socially housed adolescent guinea pigs

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