Dietary Fermented Soybean Suppresses UVB-Induced Skin Inflammation in Hairless Mice via Regulation of the MAPK Signaling Pathway

Lee, Taek Hwan; Ho, Moon; Oh, Young Lyun; Cho, Dong Woon; Kim, Seung Hyun; Kim, Sun Yeou

doi:10.1021/jf5018252

Cited by 44 publications

(34 citation statements)

References 47 publications

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“…Although these natural products contain many beneficial bioactive substances, there are some limits in terms of efficacy. Several studies have demonstrated that fermentation of the natural products improved biological activities [23]. Therefore, in order to enhance the beneficial effects of soybean and barley, we increased the activity of β-glucans, daidzein and genistein in barley and soybean by yeast fermentation.…”

Section: Discussionmentioning

confidence: 99%

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

Woo

Choi

Kang

et al. 2016

BMC Complement Altern Med

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BackgroundInflammatory bowel disease (IBD) is characterized by chronic or relapsing immune system activation and inflammation within the gastrointestinal tract. The lack of safety and efficacy of standard therapies, the use of food supplements for managing IBD is increasing, and many studies have reported that various food supplements provide many beneficial effects for the IBD.MethodsThis study aimed to evaluate the anti-colitis effects of dietary supplementation with a fermented barley and soybean mixture (BS) on intestinal inflammation using a murine model of IBD. Female C57BL/6 mice were administered with either BS (100 and 200 mg/kg/day) or vehicle (PBS) control through oral gavages for 3 days and received 5% dextran sulfate sodium (DSS) drinking water to induce colitis. Mice body weight was measured every two days and disease activity index (DAI) score was determined on Day 15; mice were sacrificed and colons were analyzed by H & E staining and RT-PCR. We also measured intestinal barrier function in vitro using DSS-treated Caco-2 cells by assessing ZO-1 immunofluorescence staining and Western blotting and in vivo by measuring serum level of FITC-Dextran and by performing bacteria culture from mesenteric lymph nodes (MLN) extract. The gut microbiota was examined by real time PCR using fecal DNA.ResultsWe found that BS alleviated the severity of colitis in a DSS-induced colitis mouse model, and suppressed levels of pro-inflammatory cytokines in colonic tissue. Moreover, BS prevented epithelial barrier dysfunction, inducing an increase of tight junction protein levels in colonic tissues, BS also inhibited FITC-dextran permeability, and suppressed bacterial translocation to MLNs. In addition, BS increased the levels of Lactobacilli and Bacteroides, which have anti-inflammatory properties.ConclusionOur study suggests that BS has protective roles against inflammatory bowel disease through changes in inflammatory activity, tight junction protein expression, and gut microbiota composition in DSS-induced colitis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1479-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

Woo

Choi

Kang

et al. 2016

BMC Complement Altern Med

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“…Genistein and daidzein, which are abundantly present in soy products, are also isofl avones that have diverse biological functions, including anti-allergic, anti-infl ammatory, antioxidant and anti-cancer as well E-mail: hirasaka@nagasaki-u.ac.jp as estrogenic action (13)(14)(15). Our previous study demonstrated that isofl avones prevent TNF-␣-induced myotube atrophy in C2C12 myotubes (16).…”

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confidence: 99%

“…Our previous study demonstrated that isofl avones prevent TNF-␣-induced myotube atrophy in C2C12 myotubes (16). In addition, it has been reported that the cytoprotective effects of genistein as an anti-infl ammatory agent are also mediated through the suppression of ERK signaling in pancreatic ␤-cells and skin (15,17). However, effects of isofl avones such as genistein and daidzein in counteracting muscle atrophy caused by cancer in vivo are still unknown.…”

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Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice

Hirasaka

Saito

Yamaguchi

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Proinfl ammatory cytokines contribute to the progression of muscle wasting caused by ubiquitin-proteasome-dependent proteolysis. We have previously demonstrated that isofl avones, such as genistein and daidzein, prevent TNF-␣-induced muscle atrophy in C2C12 myotubes. In this study, we examined the effect of dietary fl avonoids on the wasting of muscle. Mice were divided into the following four groups: vehicle-injected (control) mice fed the normal diet (CN); tumor-bearing mice fed the normal diet (TN); control mice fed the isofl avone diet (CI); and tumor-bearing mice fed the isofl avone diet (TI). There were no significant differences in the intake of food or body weight gain among these four groups. The wet weight and myofi ber size of gastrocnemius muscle in TN signifi cantly decreased, compared with those in CN. Interestingly, the wet weight and myofi ber size of gastrocnemius muscle in TI were nearly the same as those in CN and CI, although isofl avone supplementation did not affect the increased tumor mass or concentrations of proinfl ammatory cytokines, such as TNF-␣ and IL-6, in the blood. Moreover, increased expression of muscle-specifi c ubiquitin ligase genes encoding MAFbx/Atrogin-1 and MuRF1 in the skeletal muscle of TN was signifi cantly inhibited by the supplementation of isofl avones. In parallel with the expression of muscle-specifi c ubiquitin ligases, dietary isofl avones signifi cantly suppressed phosphorylation of ERK in tumor-bearing mice. These results suggest that dietary isofl avones improve muscle wasting in tumor-bearing mice via the ERK signaling pathway mediated-suppression of ubiquitin ligases in muscle cells.

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“…During the process of fermentation, the sugar moiety is removed from the compounds genistin and daidzin, converting them into their aglycon forms, genistein, and daidzein. [19]. When soybean extracts (25 g of soybean were extracted 2 times at room temperature with shaking for 48 hours using each solvent) were fed to Sprague-Dawley rats using various solvents (ethanol, n-hexane extract, ethyl acetate), all three extracts caused an increase in estrogen receptor-positive cells to emerge, but only a high-dose ethyl acetate extract group showed an increased amount of collagen in the skin.…”

Section: Soybean Extractsmentioning

confidence: 99%

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

Kim¹,

Kang²,

Park³

et al. 2017

JFNR

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Numerous studies have investigated the bioactive properties of compounds present in soybean (Glycine max) that may have beneficial effects on the health of human skin. Several such compounds have already been introduced into commercial cosmetic products to promote functional properties such as skin whitening, anti-wrinkle activity and skin hydration. However, a significantly greater understanding of the application of soybean ingredients in these types of products is needed before optimal benefits can be realized. In this review, we aim to summarize some of the biological properties of soybean constituents and the underlying mechanisms of action responsible for beneficial effects in skin. In addition, we will discuss future directions for studies that may help to expand the applications for soybean compounds.

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Dietary Fermented Soybean Suppresses UVB-Induced Skin Inflammation in Hairless Mice via Regulation of the MAPK Signaling Pathway

Cited by 44 publications

References 47 publications

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

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