Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies

Aune, Dagfinn; Chan, Doris S. M.; Greenwood, Darren C.; Vieira, Ana; Rosenblatt, Deborah A. Navarro; Vieira, R.; Norat, Teresa

doi:10.1093/annonc/mdr589

Cited by 200 publications

(153 citation statements)

References 56 publications

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“…482 Finally, reducing dietary fat intake, with a modest influence on body weight, may improve relapse-free survival rates of patients with breast cancer receiving conventional cancer treatment. 483 Fruits and vegetables contain large amounts of polyphenols.…”

Section: Healthy Eating Active Living and Emotional Resilience Goalsmentioning

confidence: 99%

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Bodai¹,

Tuso

2015

TPJ

286

163

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Section: Healthy Eating Active Living and Emotional Resilience Goalsmentioning

confidence: 99%

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Bodai¹,

Tuso

2015

TPJ

286

163

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“…In a recent meta-analysis of 16 prospective studies, a weak inverse association was found; for an increment of 10 g fiber per day, a 5% lower BC risk was seen. 24 Notably, most previous evidence on fiber intake and BC has been from studies in which women were enrolled during midlife or later; the effects of fiber during adolescence or early adulthood on BC incidence have been minimally studied. The atomic bombing of Hiroshima and Nagasaki and radiation treatment of Hodgkin's lymphoma indicate that breast tissue may be particularly susceptible to carcinogenic exposures during childhood and early adult life.…”

Section: What This Study Addsmentioning

confidence: 99%

Dietary Fiber Intake in Young Adults and Breast Cancer Risk

Farvid¹,

Eliassen

Cho

et al. 2016

Pediatrics

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We evaluated fiber intake during adolescence and early adulthood in relation to breast cancer (BC) risk in the Nurses' Health Study II. METHODS:Among 90 534 premenopausal women who completed a dietary questionnaire in 1991, we documented 2833 invasive BC cases during 20 years of follow-up. In 1998, 44 263 of these women also completed a questionnaire about their diet during high school; among these women, we documented 1118 cases of BC by end of follow-up. Multivariable-adjusted Cox proportional hazards regression was used to model relative risks (RRs) and 95% confidence intervals (CIs) for BC across categories of dietary fiber.RESULTS: Among all women, early adulthood total dietary fiber intake was associated with significantly lower BC risk (RR for highest versus lowest quintile 0.81; 95% CI 0.72-0.91; P trend = .002). Higher intakes of soluble fiber (RR for highest versus lowest quintile 0.86; 95% CI 0.77-0.97; P trend = .02) and insoluble fiber (RR for highest versus lowest quintile 0.80; 95% CI 0.71-0.90; P trend < .001) were each associated with lower BC risk. Total dietary fiber intake in adolescence was also associated with lower BC risk (RR for highest versus lowest quintile 0.84; 95% CI 0.70-1.01; P trend = .04). For the average of fiber intake during adolescence and early adult life, the RR comparing highest with lowest quintiles was 0.75 (95% CI 0.62-0.91, P trend = .004). CONCLUSIONS:Our findings support the hypothesis that higher fiber intakes reduce BC risk and suggest that intake during adolescence and early adulthood may be particularly important.

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“…A systematic review and meta-analysis of prospective studies in high-income countries showed a significant inverse association between dietary fiber intake and risk of BC 60 . The estimate suggested a decrease of 5% in the risk of BC per 10 g/day (95% CI: −9 to −2).…”

Section: Fibermentioning

confidence: 99%

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

Romieu

Amadou

Chajès

2017

RIC

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The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood. Despite limited data on BC in young women, evidence points to the importance of a healthy lifestyle, including high intake of vegetables, fruits, legumes, fish, and poultry, low intake of sugar and fat, daily physical activity, low alcohol consumption, steady weight, and breastfeeding in preventing BC in young women. Preventive efforts should begin in early life to provide important benefits much later in life by shifting the long-term trajectory of risk accumulation. Data from Latin America and developing regions are still sparse. There is a need to harmonize studies in a global effort to fight the rise of BC incidence in low-and middle-income countries, where the nutritional transition is occurring rapidly. The stratification of BC by specific tumor characteristics needs to be considered since risk factors may be more particularly associated with the promotion of, or protection from, a defined type of BC.

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Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies

Abstract: In this meta-analysis of prospective studies, there was an inverse association between dietary fiber intake and breast cancer risk.

Cited by 200 publications

References 56 publications

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

Dietary Fiber Intake in Young Adults and Breast Cancer Risk

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

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