Dietary fiber and cholesterol and bile acid metabolism in axenic (germfree) and holoxenic (conventional) rats. — III. Effect of non-sterilized pectin

Sacquet, E; Leprince, C.; Riottot, Michel; Raibaud, P.

doi:10.1051/rnd:19850109

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…This finding is important because β-glucan is a fiber with well-known hypocholesterolemic effects – , to the extent that the U.S. Food and Drug Administration allows cardiovascular risk reduction claims for oat β-glucan . The lipid-lowering capacity of pectin has been reported previously in rats ,,,, and in humans . Similar effects were observed when apple-supplemented diets were used ,, .…”

Section: Discussionmentioning

confidence: 78%

Highly Methoxylated Pectin Improves Insulin Resistance and Other Cardiometabolic Risk Factors in Zucker Fatty Rats

Sánchez¹,

Muguerza²,

Moulay³

et al. 2008

J. Agric. Food Chem.

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In this study, we evaluated the effect of a highly methoxylated apple pectin (HMAP) on cardiometabolic risk factors in Zucker fatty rats. beta-Glucan, a fiber known for its hypocholesterolemic properties, also was used. The rats fed both fiber-enriched diets exhibited a reduction in body weight and in total cholesterol and triglycerides when compared to the Zucker fatty rats fed the standard diet. The effect on the lipid profile was more remarkable in the HMAP group. A decrease in blood glucose was only noticed in this group. Moreover, a decrease in plasma insulin, HOMA-IR, and HOMA-beta was noticed in the fiber groups, and in particular in the HMAP group, these variables being similar to the lean rats. Blood pressure and endothelial function were similar in all the Zucker fatty rats. These results warrant evaluation in humans to determine if HMAP could be used as a functional ingredient to reduce lipid profile, insulin resistance, and other cardiometabolic risk factors.

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Section: Discussionmentioning

confidence: 78%

Highly Methoxylated Pectin Improves Insulin Resistance and Other Cardiometabolic Risk Factors in Zucker Fatty Rats

Sánchez¹,

Muguerza²,

Moulay³

et al. 2008

J. Agric. Food Chem.

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“…Nitroreductase was not modified in either group. Non-sterilized pectin decreased the absorption coefficient of cholesterol, the plasma cholesterol concentration and the faecal excretion of cholesterol in holoxenic rats but not in axenic rats, which suggest that there were functional modifications of the gastrointestinal flora (Sacquet et al 1985). The effect of dietary carbohydrates that are indigestible or difficult to digest on certain metabolic activities of bacterial origin, such as the epimerization of p-muricholic acid into w-muricholic acid, in holoxenic rats kept in isolators could be reversed (Andrieux et al 1980): the metabolic activity disappeared once the rats ingested the resistant carbohydrate and reappeared when they received a diet containing digestible starch.…”

Section: Simple-stomached Animalsmentioning

confidence: 99%