Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

Chen, Kangning; Zhao, Qianyu; Li, Xiaofan; Zhao, Jing; Li, Peiqin; Lin, Shuchun; Wang, Hongwei; Zang, Jiajie; Xiao, Ying; Xu, Wanghong; Chen, Fuxue; Gao, Ying

doi:10.3390/nu10070945

Cited by 20 publications

(16 citation statements)

References 43 publications

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“…A direct association between a high glycemic load (GL) diet and the risk of endometrial cancer was reported by several studies [ 23 , 24 ], but the evidence is not fully consistent [ 25 , 26 , 27 ]. Evidence is suggestive but inconclusive for a direct association with the intake of red and processed meat [ 28 , 29 , 30 , 31 , 32 ] and for inverse associations with the intakes of cereal fiber [ 33 , 34 , 35 ] and fruit [ 30 , 32 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Risk Reduction Diet and Endometrial Cancer Risk

et al. 2021

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Diabetes increases endometrial cancer risk. We investigated the role of a diabetes risk reduction diet (DRRD) on the risk of endometrial cancer using data from a multicentric, Italian hospital-based case–control study (1992–2006) enrolling 454 histologically confirmed cases of endometrial cancer and 908 controls matched by age and center. We derived a DRRD score assigning higher scores for higher intakes of cereal fiber, fruit, coffee, polyunsaturated:saturated fatty acid ratio, and nuts and for lower glycemic load and lower intakes of red/processed meat and sugar-sweetened beverages/fruit juices. The odds ratios (OR) of endometrial cancer according to the DRRD score were derived by multiple conditional logistic regression models. The OR for high (DRRD score >24, i.e., third tertile) versus medium–low adherence to the DRRD was 0.73 (95% confidence interval, CI, 0.55–0.97). Similar results were observed after the exclusion of diabetic women (OR 0.75; 95% CI, 0.56–1.00) and allowance for total vegetable consumption (OR 0.80; 95% CI, 0.60–1.07). Inverse associations were observed in most of the analyzed subgroups. The OR for high DRRD combined with high vegetable consumption was 0.45 (95% CI, 0.28–0.73). Our results suggest that diets able to reduce diabetes risk may also reduce endometrial cancer risk. High vegetable consumption combined with high adherence to the DRRD may provide additional benefit in endometrial cancer prevention.

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Section: Introductionmentioning

confidence: 99%

Diabetes Risk Reduction Diet and Endometrial Cancer Risk

et al. 2021

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“…The random-effects summary estimate was 0.71 (95% CI: 0.59, 0.85) for the comparison of the highest with the lowest dietary fiber intake in 8 case-control studies [44]. A significant negative association was observed between total dietary fiber intake and endometrial cancer risk in 11 casecontrol studies (OR = 0.76, 95% CI: 0.64~0.89) [45]. But no association was found in the cohort study, even positive correlations of higher total fiber and cereal fiber intake with endometrial cancer risk [44][45].…”

Section: Endometrial Carcinomamentioning

confidence: 92%

“…A significant negative association was observed between total dietary fiber intake and endometrial cancer risk in 11 casecontrol studies (OR = 0.76, 95% CI: 0.64~0.89) [45]. But no association was found in the cohort study, even positive correlations of higher total fiber and cereal fiber intake with endometrial cancer risk [44][45]. Li HJ et al [46] found a significant association between dietary fiber intake and endometrial carcinoma (RR = 0.86, 95% CI: 0.78, 0.93) .The findings revealed that the consumption of dietary fiber was associated with a 14% reduction in endometrial carcinoma risk.…”

Section: Endometrial Carcinomamentioning

confidence: 96%

A Review of the Associations between Dietary Fiber Intake and Cancer Prevention or Prognosis

Xie¹,

Ren²,

Li³

et al. 2020

Journal of Nutritional Oncology

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The increase in tumor incidence is closely related to dietary factors. In recent years, many researchers have carried out in-depth research to investigate whether increasing the intake of dietary fiber can prevent tumors and improve the prognosis, but the results have been unclear. We herein searched the literature in common academic databases and incorporated and summarized the relevant articles. The literature clearly indicates that dietary fiber can protect against the following cancers: colorectal cancer, breast cancer, pancreatic cancer, ovarian cancer, and head and neck cancer. There is also evidence that dietary fiber intake can exert protective effects against cancers of the liver, lung, stomach, small bowel, kidney, and esophagus, as well as lymphoma, but the data have so far been relatively limited. The effects on endometrial cancer and prostate cancer still remain uncertain. In terms of the effects on the cancer prognosis, dietary fiber does not appear to have an impact on colorectal cancer or breast cancer. Although more research is needed for some kinds of cancer, it is clear that increasing the intake of dietary fiber is beneficial for preventing the occurrence and development of several major types of cancer, with no major adverse effects. We therefore recommend that most of individuals increase their intake of dietary fiber.

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“…Adequate fiber intake is associated with digestive health and reduced risk of several noncommunicable diseases, and is recognized as essential for human health (1)(2)(3)(4)(5)(6)(7) . In terms of gastrointestinal (GI) conditions, evidence has suggested that adequate fiber intake has also potential benefits in the management of chronic constipation and irritable bowel syndrome (8,9) .…”

Section: Introductionmentioning

confidence: 99%

Patterns of Fiber Intake Among Brazilian Adults: Perceptions From an Online Nationwide Survey

Passos

Takemoto

Guedes³

2020

Arq. Gastroenterol.

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BACKGROUND: Adequate fiber intake is associated with digestive health and reduced risk of several noncommunicable diseases and is recognized as essential for human health (World Health Organization, 2003). The World Health Organization (WHO) recommends a daily fiber consumption of ≥25 g, but previous studies observed a fiber intake in Brazil lower than recommended. OBJECTIVE: We aimed to describe fiber intake among adults in Brazil and also respondents’ knowledge and perceptions about their fiber intake. METHODS: National online survey with community-dwelling Brazilian individuals. The survey was conducted during September 2018, using an online platform with closed-ended questions. A representative sample of Brazilian internet users stratified by sex, age, socioeconomic status and geographic region was adopted. Sample size was calculated using a 2% error margin and 95% confidence interval (n=2,000). Data was descriptively analyzed using measures of frequency, central tendency and dispersion. RESULTS: Sample included 2,000 individuals who were well-balanced in terms of sex (51.2% female), with mean age of 35.9 years (most represented age group was 35-54 years, 39.6%) and from all country geographic regions (49.4% from Southeast). A total of 69.7% of them consider their usual diet as healthy and 78.4% reported consuming fibers regularly. Fibers from natural sources are consumed at least once a day by 69.5% of the sample, while daily fiber supplements were reported by 29.9%. Absence of regular fiber intake was reported by 21.7% of respondents and the most common reason was “lack of knowledge about fiber sources” (39.3%). When informed about the food sources of each type of fiber (soluble and insoluble) and asked about the regular intake, only 2.5% answered that they do not consume any of them regularly (as opposed to 21.7% before receiving information about specific fiber sources). CONCLUSION: Our findings indicate that fiber intake in Brazil is probably insufficient with a high proportion of individuals reporting irregular or absent ingestion of fiber sources in their daily lives. Lack of knowledge about fiber sources and fiber types seems to play a role in this inadequate intake, highlighting the need for nutritional education to achieve healthy dietary patterns in the country.

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Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

Cited by 20 publications

References 43 publications

Diabetes Risk Reduction Diet and Endometrial Cancer Risk

Diabetes Risk Reduction Diet and Endometrial Cancer Risk

A Review of the Associations between Dietary Fiber Intake and Cancer Prevention or Prognosis

Patterns of Fiber Intake Among Brazilian Adults: Perceptions From an Online Nationwide Survey

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