Dietary fiber intake reduces risk of inflammatory bowel disease: result from a meta-analysis

Liu, Xiaoqin; Wu, Yili; Fang, Li; Zhang, Dongfeng

doi:10.1016/j.nutres.2015.05.021

Cited by 96 publications

(56 citation statements)

References 25 publications

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“…However, as another major subtype of carbohydrate, high fiber intake could decrease CD risk. The result was consistent with the meta-analysis of Liu et al, which also found dietary fiber intake could reduce the risk of CD (the highest vs. the lowest category: RR (95% CI): 0.44 (0.29–0.69)) [34]. In subgroup analysis, when not adjusted for smoking, a lower RR was observed with higher fiber intake, but the same finding was not present with an adjustment for smoking.…”

Section: Discussionsupporting

confidence: 90%

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Zeng

Chen

et al. 2017

Nutrients

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Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to identify all relevant studies, and the role of macronutrients in the development of CD was quantitatively assessed by dose–response meta-analysis. Four case-control studies (a total of 311 CD cases and 660 controls) and five prospective cohort studies (238,887 participants and 482 cases) were identified. The pooled relative risks (RR) for per 10 g increment/day were 0.991 (95% confidence interval (CI): 0.978–1.004) for total carbohydrate intake, 1.018 (95% CI: 0.969–1.069) for total fat intake, and 1.029 (95% CI: 0.955–1.109) for total protein intake. Fiber intake was inversely associated with CD risk (RR for per 10 g increment/day: 0.853, 95% CI: 0.762–0.955), but the association was influenced by study design and smoking adjustment. In subtypes, sucrose intake was positively related with CD risk (RR for per 10 g increment/day: 1.088, 95% CI: 1.020–1.160). Non-linear dose–response association was also found between fiber and sucrose intake and CD risk. In conclusion, this meta-analysis suggested a lack of association between total carbohydrate, fat or protein intake and the risk of CD, while high fiber intake might decrease the risk. In subtypes, high sucrose intake might increase the risk of CD.

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Section: Discussionsupporting

confidence: 90%

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Zeng

Chen

et al. 2017

Nutrients

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“…A total of 145 meta-analytic estimates were retained for the main analysis: 74 (51%) reported effects that were significant at P < .05 and 32 (22%) at P < .001. The putative environmental factors pertained to lifestyles and hygiene (n ¼ 16), 6,18-30 surgeries (n ¼ 2), exposure to drugs (n ¼ 3), [37][38][39][40][41][42] dietary intake and nutrients (n ¼ 22), [43][44][45][46][47][48][49][50][51][52][53][54][55] and microorganisms and vaccinations (n ¼ 28). [56][57][58][59][60][61][62][63][64][65][66][67][68][69] Quality Assessment of Meta-analyses The AMSTAR 2 rating for all studies was determined to be critically low (31 studies, 60%) or low (21 studies, 40%) (Supplementary Table 4).…”

Section: Search Resultsmentioning

confidence: 99%

“…47 Fiber intake reduced the risk of CD (RR, 0.85; 95% CI, 0.76-0.96; per 10-g increment/day) but not UC, with evidence of a dose-response relationship (P ¼ .02). 44,45,48 Some of these findings are biologically plausible. Plant components may affect the translocation of microbes across the gut mucosa, 96 and flavonoids can influence the maintenance of intestinal barrier function, 97 which is impaired in IBD.…”

Section: Exposure To Drugsmentioning

confidence: 86%

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

et al. 2019

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Our study protocol was registered with PROSPERO (registration number: CRD42018112214). We followed a standardized methodology 7 and report findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (ie, PRISMA) 8 and Meta-analyses of Observational Studies in Epidemiology (ie, MOOSE) 9 recommendations. Search Strategy We systematically searched PubMed, Embase, and Scopus from inception through September 28, 2018, to identify metaanalyses of studies assessing the association between environmental factors and IBD. Search terms included inflammatory bowel disease, Crohn's disease, or ulcerative colitis, combined with systematic review or meta-analysis. We excluded conference abstracts, letters, editorials, and articles published in languages other than English. The reference lists of the identified meta-analyses were screened for additional eligible articles. No other restrictions were imposed.

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“…Although no specific pediatric study has been performed, several trials in adults have evaluated the effectiveness and mechanisms of action of fiber in IBD. Based on the published RCT in adults and on 3 systematic reviews, there is limited evidence for the effectiveness of fiber supplementation in active UC and in maintenance of remission in UC and pouchitis (253,254,(263)(264)(265)(266)(267)(268)(269)(270)(271)(272)(273)(274). Data in active UC are conflicting, Copyright © ESPGHAN and NASPGHAN.…”

Section: Practice Pointsmentioning

confidence: 99%

Nutrition in Pediatric Inflammatory Bowel Disease

Miele

Shamir

Aloi

et al. 2018

J. pediatr. gastroenterol. nutr.

140

113

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Dietary fiber intake reduces risk of inflammatory bowel disease: result from a meta-analysis

Cited by 96 publications

References 25 publications

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Nutrition in Pediatric Inflammatory Bowel Disease

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