Dietary fiber modulates abdominal fat deposition associated with cecal microbiota and metabolites in yellow chickens

Cui, Xiaoyan; Gou, Zhongyong; Jiang, Zhonghong; Li, Long; Lin, Xuhui; Fan, Qiuli; Wang, Yibing; Jiang, Sufei

doi:10.1016/j.psj.2022.101721

Cited by 14 publications

(10 citation statements)

References 45 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FVW might provide abundant dietary fiber for the gut microbiota, thereby changing the interaction between members of the microbiota (from competitive symbiosis to mutualistic symbiosis). In contrast with previous studies, this study supports the intervention effect of dietary fiber supplementations on the microbe-microbe interaction ( 19 , 80 , 81 ).…”

Section: Discussioncontrasting

confidence: 71%

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 71%

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

et al. 2023

View full text Add to dashboard Cite

show abstract

“…A recent report indicated that broilers produced ≈3 million tons of abdominal fat around the world annually, which results in >$2.7 billion economic loss in the poultry industry 4 , leading to a key hindrance to profitable farming 5 . Although it is an appreciable energetic component, it has to be removed during evisceration and is considered a waste in chicken meat production 6 . Abdominal fat deposition decreases feed utilization, reduces the reproduction performance of laying hens, negatively affects the slaughtering process, and causes environmental pollution 2 , 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism

Chen

Akhtar

et al. 2023

npj Biofilms Microbiomes

View full text Add to dashboard Cite

Cecal microbiota plays an essential role in chicken health. However, its contribution to fat metabolism, particularly in abdominal fat deposition, which is a severe problem in the poultry industry, is still unclear. Here, chickens at 1, 4, and 12 months of age with significantly (p < 0.05) higher and lower abdominal fat deposition were selected to elucidate fat metabolism. A significantly (p < 0.05) higher mRNA expression of fat anabolism genes (ACSL1, FADS1, CYP2C45, ACC, and FAS), a significantly (p < 0.05) lower mRNA expression of fat catabolism genes (CPT-1 and PPARα) and fat transport gene APOAI in liver/abdominal fat of high abdominal fat deposition chickens indicated that an unbalanced fat metabolism leads to excessive abdominal fat deposition. Parabacteroides, Parasutterella, Oscillibacter, and Anaerofustis were found significantly (p < 0.05) higher in high abdominal fat deposition chickens, while Sphaerochaeta was higher in low abdominal fat deposition chickens. Further, Spearman correlation analysis indicated that the relative abundance of cecal Parabacteroides, Parasutterella, Oscillibacter, and Anaerofustis was positively correlated with abdominal fat deposition, yet cecal Sphaerochaeta was negatively correlated with fat deposition. Interestingly, transferring fecal microbiota from adult chickens with low abdominal fat deposition into one-day-old chicks significantly (p < 0.05) decreased Parabacteroides and fat anabolism genes, while markedly increased Sphaerochaeta (p < 0.05) and fat catabolism genes (p < 0.05). Our findings might help to assess the potential mechanism of cecal microbiota regulating fat deposition in chicken production.

show abstract

“…It has been established that gut microbiota could control abdominal fat deposition by regulating fat metabolism [14]. It is also well-known that an obese host harbors more Firmicutes than Bacteroidetes and a higher Firmicutes/Bacteroidetes ratio [12,36].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence revealed that colonization of the obese microbiota promoted fat deposition in mice [13]. For example, a higher abundance of Methanobrevibacter and Faecalibacterium, while a lower abundance of Akkermansia increases fat deposition [4,14]. Further studies indicated that gut microbiota in uences and modulates fat metabolism, and importantly contributes to nutrient utilization, generating additional harvestable energy and resulting in abdominal fat deposition [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…For example, a higher abundance of Methanobrevibacter and Faecalibacterium, while a lower abundance of Akkermansia increases fat deposition [4,14]. Further studies indicated that gut microbiota in uences and modulates fat metabolism, and importantly contributes to nutrient utilization, generating additional harvestable energy and resulting in abdominal fat deposition [14,15]. For instance, Enterococcus faecium increases fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) secretion in chicken liver [16], and elevated FAS and ACC increases fatty acid production, which incorporates into triglyceride and increases fat deposition [17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism

Chen

Akhtar

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Rapidly developed broilers are often accompanied by excessive fat deposition and markedly decreased feed utilization, which is a severe problem in the poultry industry. Recent studies established that gut microbiota significantly alters chicken fat deposition. However, what kind of cecal bacteria can regulate fat deposition and how they control fat deposition remains unclear. Results: The abdominal fat weight and index, and average diameter of adipocytes were markedly higher in high than in low abdominal fat deposition chickens at different time points (1, 4, and 12 months). The higher expression levels of fat synthesis related genes (ACSL1, FADS1, CYP2C45, ACC, and FAS) and a lower expression of fat catabolism genes (CPT-1, and PPARα) in the liver and abdominal fat of high abdominal fat deposition chickens, indicated that an unbalanced fat metabolism leads to excessive abdominal fat deposition. Parabacteroides, Parasutterella, Oscillibacter, and Anaerofustis were found higher in high abdominal fat deposition chickens, while Bacteroides and Sphaerochaeta were higher in low abdominal fat deposition chickens at different time points. Further, Spearman correlation analysis indicated that the relative abundance of Parabacteroides, Parasutterella, Oscillibacter, and Anaerofustis was positively correlated with abdominal fat weight and index, and the expression level of fat anabolism genes, yet the relative abundance of Bacteroides and Sphaerochaeta was negatively correlated with these factors. Furthermore, transferring fecal microbiota from adult chickens with low abdominal fat deposition into one-day-old chicks significantly decreased Parabacteroides, abdominal fat weight and index, and fat anabolism genes, while markedly increased Bacteroides and Sphaerochaeta and fat catabolism genes. Conclusion: Our findings highlighted that Bacteroides and Sphaerochaeta might reduce abdominal fat deposition, yet Parabacteroides Parasutterella, Oscillibacter, and Anaerofustis could promote abdominal fat deposition by regulating fat metabolism.

show abstract

Dietary fiber modulates abdominal fat deposition associated with cecal microbiota and metabolites in yellow chickens

Cited by 14 publications

References 45 publications

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism

Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism

Contact Info

Product

Resources

About