Dietary fibers obtained from Caulerpa lentillifera prevent high-fat diet-induced obesity in mice by regulating the gut microbiota and metabolite profiles

Abstract

With the expansion of farming and increasing consumption, Caulerpa lentillifera has received extensive attention. In the present study, the physicochemical properties of insoluble dietary fiber from C. lentillifera (CL-IDF) were...

Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

“…Natural antioxidants can present a viable therapeutic target in helping to correct the negative effects of obesity, cancer, and oxidative stress [ 31 , 32 ]. You et al [ 33 ] have studied isolated dietary fiber from C. lentillifera for the first time to identify its potential anti-obesity activity. However, the study by You et al [ 33 ] has not shown potential anti-obesity effects through the lipase inhibition pathway.…”

“…You et al [ 33 ] have studied isolated dietary fiber from C. lentillifera for the first time to identify its potential anti-obesity activity. However, the study by You et al [ 33 ] has not shown potential anti-obesity effects through the lipase inhibition pathway. This study demonstrates that C. lentillifera can be an antioxidant agent with anti-obesity effects since it has an antioxidant capacity (EC 50 MH is very close to EC 50 Trolox/control positive) followed by anti-obesity properties via lipase inhibition (EC 50 MH < EC 50 orlistat/control positive)—a useful precursor to new therapeutic approaches in improving obesity-related diseases.…”

Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

“…The physiochemical and structural properties of TCMPOs, as shown in Figure 1 , mainly including monosaccharide compositions, Mw, and backbone structures (configuration, type, position of glycosidic linkage, sequence of monosaccharide), as well as conformational features, have been investigated and identified by various chemical and instrumental analyses, such as acid hydrolysis, periodate oxidation analysis, methylation analysis, smith degradation, gas chromatography (GC) ( 49 ), gas chromatography–mass spectrometry (GC–MS) ( 53 ), ultraviolet (UV) detection ( 23 , 32 ), ion chromatography (IC) ( 54 ), infrared spectroscopy (IR) ( 32 ), Fourier transform-infrared (FT-IR) spectroscopy ( 48 ), nuclear magnetic resonance (NMR) spectroscopy ( 55 ), high-performance liquid chromatography (HPLC) ( 56 ), high-performance size exclusion chromatography (HPSEC) ( 57 ), high-performance gel permeation chromatography (HPGPC) ( 58 ), scanning electron microscopy (SEM) ( 48 ), atomic force microscopy (AFM) and X-ray diffraction (XRD) ( 37 , 48 , 59 ). The structural characteristics of various TCMPOs, including their monosaccharide compositions, average Mw, backbone structures as well as conformational structures, are exhibited in Table 2 , together with the sources, geographical origins and structural characterization methods.…”

“…The biofunctional activities of TCMPOs could be affected by their backbones and conformational properties. Prior studies have demonstrated that the structural properties of polysaccharides, including types of glycosidic bonds, monosaccharide compositions and molar ratios, degrees of branching (DBs) in the backbone, are closely related to their biological activity ( 59 , 79 , 80 ). Studies have found that β-glycosidic linkages usually exhibit stronger antiobesity activity than α-glycosidic linkages, causing the α-amylase in human small intestine which is specific for α-glycosidic linkages ( 55 , 75 ).…”

Inquiry of modulatory role of sea buckthorn fruit oil on dyslipidemia and gut microbiota in hyperlipidemia mice

“…The formation of lipid metabolism disorder and hyperlipidemia is commonly accompanied by an imbalance in the intestinal microbiota . To assess the richness and diversity of the intestinal microbiota, the ACE and Chao1 indices were utilized to evaluate the species richness, while the Shannon and Simpson indices were utilized to assess the diversity (You et al, 2022). As shown in Fig.…”