Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Zamora-Ros, Raúl; Ferrari, Pietro; González, Carlos A.; Tjønneland, Anne; Olsen, Anja; Bredsdorff, Lea; Overvad, Kim; Touillaud, Marina; Perquier, Florence; Fagherazzi, Guy; Lukanova, Annekatrin; Tikk, Kaja; Aleksandrova, Krasimira; Boeing, Heiner; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Dilis, Vardis; Masala, Giovanna; Sieri, Sabina; Mattiello, Amalia; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, H. Bas; Peeters, Petra H.; Weiderpass, Elisabete; Skeie, Guri; Engeset, Dagrun; Menéndez, Virginia; Travier, Noémie; Molina‐Montes, Esther; Amiano, Pilar; Chirlaque, María Dolores; Barricarte, Aurelio; Wallström, Peter; Sonestedt, Emily; Sund, Malin; Landberg, Rikard; Khaw, Kay Thee; Wareham, Nicholas J.; Travis, Ruth C.; Scalbert, Augustin; Ward, Heather; Riboli, Elio; Romieu, Isabelle

doi:10.1007/s10549-013-2483-4

Cited by 51 publications

(39 citation statements)

References 54 publications

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“…Similarly, lignan exposure has been inconsistently associated with postmenopausal breast cancer risk, both in studies based on lignan intake assessment (125, 132) and in studies based on lignan biomarkers (125, 137). The limited knowledge of the dietary precursors of mammalian lignans (114) makes the comparison between both types of studies difficult and suggests that current food-composition tables for the few lignans often present in trace amounts in foods are insufficient to assess exposure to mammalian lignans.…”

Section: Measurement Of Polyphenol Exposure In Observational Epidemiomentioning

confidence: 99%

Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits

Zamora-Ros¹,

Touillaud

Rothwell³

et al. 2014

The American Journal of Clinical Nutrition

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121

143

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Much experimental evidence supports a protective role of dietary polyphenols against chronic diseases such as cardiovascular diseases, diabetes, and cancer. However, results from observational epidemiologic studies are still limited and are often inconsistent. This is largely explained by the difficulties encountered in the estimation of exposure to the polyphenol metabolome, which is composed of ∼500 polyphenols distributed across a wide variety of foods and characterized by diverse biological properties. Exposure to the polyphenol metabolome in epidemiologic studies can be assessed by the use of detailed dietary questionnaires or the measurement of biomarkers of polyphenol intake. The questionnaire approach has been greatly facilitated by the use of new databases on polyphenol composition but is limited by bias as a result of self-reporting. The use of polyphenol biomarkers holds much promise for objective estimation of polyphenol exposure in future metabolome-wide association studies. These approaches are reviewed and their advantages and limitations discussed by using examples of epidemiologic studies on polyphenols and cancer. The current improvement in these techniques, along with greater emphasis on the intake of individual polyphenols rather than polyphenols considered collectively, will help unravel the role of these major food bioactive constituents in disease prevention.

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Section: Measurement Of Polyphenol Exposure In Observational Epidemiomentioning

confidence: 99%

Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits

Zamora-Ros¹,

Touillaud

Rothwell³

et al. 2014

The American Journal of Clinical Nutrition

Self Cite

121

143

View full text Add to dashboard Cite

show abstract

“…Flavonol intake was associated with decreased risk of hepatocellular carcinoma (48). However, no association between flavonoid intake and breast cancer risk was identified (49), although a recent meta-analysis concluded that flavanol and flavone intake may inversely associate with breast cancer risk (50).…”

Section: -Day Dietmentioning

confidence: 99%

A Food Frequency Questionnaire Validated for Estimating Dietary Flavonoid Intake in an Australian Population

Somerset

Papier

2014

Nutrition and Cancer

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Flavonoids, a broad category of nonnutrient food components, are potential protective dietary factors in the etiology of some cancers. However, previous epidemiological studies showing associations between flavonoid intake and cancer risk have used unvalidated intake assessment methods. A 62-item food frequency questionnaire (FFQ) based on usual intake of a representative Australian adult population sample was validated against a 3-day diet diary method in 60 young adults. Spearman's rank correlations showed 17 of 25 individual flavonoids, 3 of 5 flavonoid subgroups, and total flavonoids having strong/moderate correlation coefficients (0.40-0.70), and 8 of 25 individual flavonoids and 2 of 5 flavonoid subgroups having weak/insignificant correlations (0.01-0.39) between the 2 methods. Bland-Altman plots showed most subjects within ±1.96 SD for intakes of flavonoid subgroups and total flavonoids. The FFQ classified 73-90% of participants for all flavonoids except isorhamnetin, cyanidin, delphinidin, peonidin, and pelargonidin; 73.3-85.0% for all flavonoid subgroups except Anthocyanidins; and 86.7% for total flavonoid intake in the same/adjacent quartile determined by the 3-day diary. Weighted kappa values ranged from 0.00 (Isorhamnetin, Pelargonidin) to 0.60 (Myricetin) and were statistically significant for 18 of 25 individual flavonoids, 3 of 5 subgroups, and total flavonoids. This FFQ provides a simple and inexpensive means to estimate total flavonoid and flavonoid subgroup intake.

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“…9, 10, 11, 12, 13, 14 The majority of studies on the relationship between flavonoid intake and obesity have focused on intake of specific flavonoids subtypes and body mass index or weight gain 15, 16 or lipid metabolism; 17 with very few assessing the relationship between overall flavonoid intake and obesity. The objective of this study was to determine the relationship between flavonoid consumption and obesity in a representative sample of 9551 US adults.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults

Vernarelli

Lambert

2017

Nutr. Diabetes

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Recent studies have demonstrated the importance of flavonoid intake and disease risk, however the association between flavonoid intake and obesity has not been evaluated in a nationally representative sample of US adults. The objective of the study was to evaluate the association between flavonoid consumption and established risk factors for obesity and obesity-related inflammation. Data from a nationally representative sample of 9551 adults who participated in the 2005–2008 National Health and Nutrition Examination Survey (NHANES) were analyzed. Flavonoid consumption was inversely associated with obesity in both men and women in multivariate models. Adults in the highest quartile of flavonoid intake had significantly lower body mass index and waist circumference than those in the lowest quartile of flavonoid intake (P<0.03 and P<0.04, respectively), and flavonoid intake was inversely related to C-reactive protein levels in women (p-trend, 0.01). These findings support a growing body of laboratory evidence that flavonoid consumption may be beneficial for disease prevention.

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Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Abstract: This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.6

Cited by 51 publications

References 54 publications

Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits

Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits

A Food Frequency Questionnaire Validated for Estimating Dietary Flavonoid Intake in an Australian Population

Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults

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