Dietary Flavonoids, Copper Intake, and Risk of Metabolic Syndrome in Chinese Adults

Qu, Rongge; Jia, Yubing; Liu, Junyi; Jin, Songqing; Han, Tianshu; Na, Lixin

doi:10.3390/nu10080991

Cited by 24 publications

(16 citation statements)

References 29 publications

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“…Recent work indicated that insufficient copper may be important in obesity, ischemic heart disease and metabolic syndrome (Morrell et al, 2017). A cross-sectional study in China showed a strong negative correlation between copper intake and metabolic syndrome, increasing copper intake could reduce the risk of metabolic syndrome, and similar reports in Korea (Choi & Bae, 2013;Qu et al, 2018). These studies were similar to our findings.…”

Section: Discussionsupporting

confidence: 91%

Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. adults using quantile regression analysis NHANES 2007–2014

Jiang¹,

Ma²,

Li³

et al. 2020

PeerJ

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Objective Mineral nutrients play an important role in maintaining material and energy metabolism. Reports on mineral nutrient intakes and body mass index (BMI) and waist circumference (WC) are rare in the United States. This study examined the relationship between BMI, WC and dietary mineral intakes. Method We used the data from National Health and Nutrition Examination Survey 2007–2014. Nutrient intakes were adjusted for energy according to the residual adjustment method. We used the quantile regression model to analyze the relationship between BMI, WC under different distributions and the average daily mineral intakes. Result A total of 19,952 people were included in the study, including 9,879 men and 10,073 women (≥20 years old). The median BMI was 27.935 kg/m2 and the median WC was 97.700 cm. The results of quantile regression showed that calcium, magnesium, potassium, copper, zinc and iron intakes were negatively correlated with BMI and WC, after adjusting for age and gender. Sodium and phosphorus intakes were positively correlated with BMI, sodium intakes were positively correlated with WC. This correlation was enhanced with increasing quantiles of risk levels. In high BMI or high WC populations, mineral intakes had a greater impact on BMI and WC. The quantile regression coefficients of selenium intakes were not statistically significant at each quantile. Conclusion Our results suggested that the mineral nutrient intakes were associated with BMI and WC in American adults. However, we also need to further study the longitudinal effects of mineral intakes and obesity.

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Section: Discussionsupporting

confidence: 91%

Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. adults using quantile regression analysis NHANES 2007–2014

Jiang¹,

Ma²,

Li³

et al. 2020

PeerJ

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“…In recent years, epidemiological studies have examined the association between dietary flavonoids and cardiometabolic risk factors that were highly correlated with NAFLD. Existing observational studies have suggested that a higher intake of dietary flavonoids was associated with a lower prevalence of insulin resistance in British people (10) , a lower prevalence of the metabolic syndrome in Chinese adults (31) and lower levels of serum lipids in humans (32,33) . However, limited data were available for NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Higher flavonoid intake is associated with a lower progression risk of non-alcoholic fatty liver disease in adults: a prospective study

Zhong

Xiong

et al. 2020

Br J Nutr

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Flavonoid-rich foods have shown a beneficial effect against non-alcoholic fatty liver disease (NAFLD) in short-term randomized trials and animal experiments. It is uncertain whether the usual dietary intake of flavonoids may benefit patients with NAFLD. This study evaluated the association between the usual intake of total flavonoids and their subclasses and the risk of progression in NAFLD. The prospective study included 2694 adults from the Guangzhou Nutrition & Health Study. Face-to-face interviews using a 79-item food frequency questionnaire were administered to assess habitual dietary flavonoid intake, while abdominal ultrasonography was conducted to evaluate the presence and degree of NAFLD, with measurements conducted three years apart. After adjustment for potential confounders, higher flavonoid intakes were gradely associated with reduced risks of worsen NAFLD status. The relative risks (95% CI) of worsening (vs. non-worsening) NAFLD in the highest (vs. lowest) quintile were 0.71 (0.54, 0.93) for total flavonoids, 0.74 (0.57, 0.95) for flavanones, 0.74 (0.56, 0.96) for flavan-3-ols, 0.90 (0.68, 1.18) for flavonols, 0.73 (0.56, 0.93) for flavones, 0.79 (0.61, 1.02) for isoflavones and 0.74 (0.57, 0.96) for anthocyanins. Sub-group analysis found that the beneficial associations were evident only in overweight/obese participants (P-interactions=0.015). An L-shaped (non-linear) relationship was observed between total flavonoid intake and the risk of NAFLD progression. Path analyses showed that the association between flavonoids and NAFLD progression was mediated by decreases in serum cholesterol and HOMA-IR. This prospective study showed that higher flavonoids intake was associated with a lower risk of NAFLD progression in the elderly overweight/obese Chinese population.

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“…Taking MetS and micronutrients into consideration, dietary intake of Zn was associated with a reduced risk of MetS [ 13 ], but dietary intake of Cu and Fe was associated with an increased risk of MetS [ 14 ]. However, little is known about the association between serum levels of Zn, Cu, or Fe and MetS while most of the results are not statistically significant [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.

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Dietary Flavonoids, Copper Intake, and Risk of Metabolic Syndrome in Chinese Adults

Cited by 24 publications

References 29 publications

Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. adults using quantile regression analysis NHANES 2007–2014

Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. adults using quantile regression analysis NHANES 2007–2014

Higher flavonoid intake is associated with a lower progression risk of non-alcoholic fatty liver disease in adults: a prospective study

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

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