Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

Murkies, Alice L.; Lombard, C. F.; Strauss, Boyd J G; Wilcox, Gisela; Burger, Henry G.; Morton, Michael S. Scott

doi:10.1016/0378-5122(95)00899-v

Cited by 378 publications

(146 citation statements)

References 15 publications

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“…Flavonoids, of which soy-based isoflavones are the most intensely studied, lower endogenous hormone levels in pre- (Dai et al, 2002;Ren et al, 2003) and post-menopausal women (Murkies et al, 1995), and inhibit transcriptional factors involved in cancer metastasis (Valachovicova et al, 2004;Slivova et al, 2005), including vascular endothelial growth factor, which is strongly associated with tumour angiogenesis (Masuda et al, 2002). These findings provide support for a biologically plausible association between dietary intake of flavonoids, particularly isoflavones, on breast cancer risk and prognosis.…”

supporting

confidence: 51%

Soy intake and breast cancer: elucidation of an unanswered question

et al. 2008

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supporting

confidence: 51%

Soy intake and breast cancer: elucidation of an unanswered question

et al. 2008

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“…Five-to 12-week treatments with soy supplements providing 0.7-1.5 mg/kg/day isoflavones did not alter serum lipids in men and women with average serum cholestrol concentrations (86,(155)(156)(157), although reductions in LDL cholesterol have been observed in hypercholesterolemic women following soy isoflavone treatment (158). However, arterial compliance, a measure of arterial elasticity, was improved in menopausal women after 10 weeks of treatment with 0.7-1.2 mg/kg/day clover isoflavones (157).…”

Section: Cardiovascular Functionmentioning

confidence: 99%

Cross-species and interassay comparisons of phytoestrogen action.

Whitten

Patisaul

2001

Environ Health Perspect

174

105

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This paper compiles animal and human data on the biologic effects and exposure levels of phytoestrogens in order to identify areas of research in which direct species comparisons can be made. In vitro and in vivo assays of phytoestrogen action and potency are reviewed and compared to actions, dose-response relationships, and estimates of exposure in human subjects. Binding studies show that the isoflavonoid phytoestrogens are high-affinity ligands for estrogen receptors (ERs), especially ER beta, but have lower potency in whole-cell assays, perhaps because of interactions with binding proteins. Many other enzymatic actions require concentrations higher than those normally seen in plasma. In vivo data show that phytoestrogens have a wide range of biologic effects at doses and plasma concentrations seen with normal human diets. Significant in vivoresponses have been observed in animal and human tests for bone, breast, ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than the doses generally reported to be active in rodents (10--100 mg/kg body weight/day), although some studies have reported rodent responses at lower doses. However, available estimates of bioavailability and peak plasma levels in rodents and humans are more similar. Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points. The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.

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“…[14][15][16] Thus, differences in other factors are likely to account for ethnic differences in vasomotor symptoms. In addition to differences in body size, hypotheses regarding racial/ethnic differences in reports of vasomotor symptoms include differences in hormone levels, 17,18 socioeconomic status, 3,7,[19][20][21][22][23][24] active or passive exposure to tobacco smoke, 4,7,19,21,[24][25][26][27] diet, [28][29][30][31][32][33][34][35][36][37][38] physical activity, 3,39 and psychosocial factors. 4,5 Determining whether race/ ethnicity-specific differences in rates of vasomotor symptoms are independent of these factors will help clarify the physiology of such symptoms and provide valuable information for women and clinicians about high-risk groups and potential behavioral interventions.…”

mentioning

confidence: 99%

Longitudinal Analysis of the Association Between Vasomotor Symptoms and Race/Ethnicity Across the Menopausal Transition: Study of Women’s Health Across the Nation

et al. 2006

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Objectives. We investigated whether vasomotor symptom reporting or patterns of change in symptom reporting over the perimenopausal transition among women enrolled in a national study differed according to race/ethnicity. We also sought to determine whether racial/ethnic differences were explained by sociodemographic, health, or lifestyle factors. Methods. We followed 3198 women enrolled in the Study of Women’s Health Across the Nation during 1996 through 2002. We analyzed frequency of vasomotor symptom reporting using longitudinal multiple logistic regressions. Results. Rates of vasomotor symptom reporting were highest among African Americans (adjusted odds ratio [OR]=1.63; 95% confidence interval [CI]=1.21, 2.20). The transition to late perimenopause exhibited the strongest association with vasomotor symptoms (adjusted OR = 6.64; 95% CI = 4.80, 9.20). Other risk factors were age (adjusted OR=1.17; 95% CI=1.13, 1.21), having less than a college education (adjusted OR = 1.91; 95% CI = 1.40, 2.61), increasing body mass index (adjusted OR=1.03 per unit of increase; 95% CI=1.01, 1.04), smoking (adjusted OR=1.63; 95% CI=1.25, 2.12), and anxiety symptoms at baseline (adjusted OR=3.10; 95% CI=2.33, 4.12). Conclusions. Among the risk factors assessed, vasomotor symptoms were most strongly associated with menopausal status. After adjustment for covariates, symptoms were reported most often in all racial/ethnic groups in late perimenopause and nearly as often in postmenopause.

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Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

Cited by 378 publications

References 15 publications

Soy intake and breast cancer: elucidation of an unanswered question

Soy intake and breast cancer: elucidation of an unanswered question

Cross-species and interassay comparisons of phytoestrogen action.

Longitudinal Analysis of the Association Between Vasomotor Symptoms and Race/Ethnicity Across the Menopausal Transition: Study of Women’s Health Across the Nation

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