Dietary Folate and the Risk of Nonfatal Myocardial Infarction

Hernández–Dı́az, Sonia; Martínez-Losa, E; Fernández-Jarne, Elena; Serrano-Martínez, Manuel; Martínez‐González, Miguel Ángel

doi:10.1097/00001648-200211000-00015

Cited by 23 publications

(14 citation statements)

References 41 publications

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“…Affordable public health recommendations are unlikely to change and the need remains for strong measures, probably involving legislation controlling inappropriate advertising to children and selective taxation and duties, along with very active health promotion, possibly emphasizing traditional diets. In this case a recent report from Spain (Hernandez-Diaz et al 2002) is encouraging. It found, in a Mediterranean population with natural plant foods as the main source of folate, a relationship supporting the hypothesis that dietary folate intake may be an independent protective factor for myocardial infarction.…”

Section: Prevention Of Diseasesupporting

confidence: 57%

Public health nutrition and genetics: implications for nutrition policy and promotion

2004

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The unravelling of the human genome has the potential to radically extend many of the strategies used in public health nutrition to improve health and to increase food availability, accessibility and utilization. The present paper divides nutrigenomics into two broad but differing areas in asking about possible public health applications: (1) the increasing mismatch between population growth and global food security, on top of the already approximately 800 million of the world population who are food insecure; (2) possible responses to the rising prevalence of non-communicable diseases as the Western diet becomes increasingly inappropriate to the needs of those consuming it. It is clear that complex interactions of multiple polymorphisms play a role in how individuals and sub-populations respond to dietary interventions. All these applications present public health and ethical challenges, particularly in ensuring that any benefits that do come from nutrigenomics are not restricted to the wealthy minority of only the affluent nations. The present paper concludes that the public health applications of nutrigenomics are probably at least a decade away, especially for developing countries. Clinical applications are likely to be more immediate, probably resulting in ‘designer diets’ for individuals with particular polymorphisms, but unless governments take on the role of ensuring some extent of equity in access, any benefits are most likely to go to those who can afford the screening, tests and treatment. At the same time, greatly increased international efforts are needed towards the continuing, and in some cases worsening, global malnutrition, as genetic manipulation of crops is unlikely to provide more than part of the solution.

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Section: Prevention Of Diseasesupporting

confidence: 57%

Public health nutrition and genetics: implications for nutrition policy and promotion

2004

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“…Thus, a possible explanation for the lack of effect of folate intake among females is that very few women in this cohort were exposed to suboptimal levels of folate intake. It is very likely that, once folate intake is sufficient to prevent subclinical folate deficiency, no further benefit is obtained by additional increases in folate intake, as observed in some studies regarding cardiovascular disease risk (Hernández‐Díaz et al. , 2002).…”

Section: Discussionmentioning

confidence: 99%

Association between folate, vitamin B₆ and vitamin B₁₂ intake and depression in the SUN cohort study

Sánchez‐Villegas

Doreste

Schlatter

et al. 2009

J Human Nutrition Diet

105

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Background: An association between low blood levels of folate, vitamins B6 and B12 and a higher prevalence of depressive symptoms has been reported in several epidemiological studies. The present study aimed to assess the association between folate, vitamins B6 and B12 intake and depresion prevalence in the SUN cohort study. Methods: The study comprised a cross‐sectional analysis of 9670 participants. A validated semi‐quantitative food frequency questionnaire was used to ascertain vitamin intake. The association between the baseline intake of folate, vitamins B6 and B12 categorised in quintiles and the prevalence of depression was assessed. The analyses were repeated after stratifying by smoking habits, alcohol intake, physical activity and personality traits. Results: Among women, odds ratios (OR) [95% confidence interval (CI)] for the third to fifth quintile for vitamin B12 intake were 0.58 (0.41–0.84), 0.56 (0.38–0.82) and 0.68 (0.45–1.04), respectively. Among those men with a low level of anxiety and current smokers, a significant positive association between low folate intake and the prevalence of depression was found. The OR (95% CI) for the first quintile of intake was 2.85 (1.49–5.45) and 2.18 (1.08–4.38), respectively, compared to the upper quintiles of intake (Q2–Q5) considered as a group. Conclusion: Low folate intake was associated with depression among currently smoking men and men with low anxiety levels. Low intake of vitamin B12 was associated with depression among women. No significant associations were found for vitamin B6 intake.

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“…The protective role of these nutrients, especially of B 6 , B 12 and folic acid on cardiovascular disease, Alzheimer or depressive disorders has been hypothesised by different epidemiological studies in the last years 3,4 . To understand the mechanisms of B vitamins involved in depression, it is important to describe the homocysteine cycle.…”

Section: Mediterranean Diet and B Vitaminsmentioning

confidence: 99%

Mediterranean diet and depression

Sánchez‐Villegas

Henríquez

Bes–Rastrollo

et al. 2006

Public Health Nutr.

135

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Objective: The adherence to a Mediterranean Dietary Pattern ensures an adequate intake of B vitamins and w-3 fatty acids. A protective role on depression has been suggested for both nutrients. Design: Cross-sectional analysis from the SUN (Seguimiento Universidad de Navarra) prospective cohort study. Data from 9670 participants (4211 men and 5459 women) were analised. Logistic regression analyses were fitted to assess the association between B-vitamins and w-3 fatty acids intake (quintiles) and the prevalence of depression.

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Dietary Folate and the Risk of Nonfatal Myocardial Infarction

Cited by 23 publications

References 41 publications

Public health nutrition and genetics: implications for nutrition policy and promotion

Public health nutrition and genetics: implications for nutrition policy and promotion

Association between folate, vitamin B₆ and vitamin B₁₂ intake and depression in the SUN cohort study

Mediterranean diet and depression

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Dietary Folate and the Risk of Nonfatal Myocardial Infarction

Cited by 23 publications

References 41 publications

Public health nutrition and genetics: implications for nutrition policy and promotion

Public health nutrition and genetics: implications for nutrition policy and promotion

Association between folate, vitamin B6 and vitamin B12 intake and depression in the SUN cohort study

Mediterranean diet and depression

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Product

Resources

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Association between folate, vitamin B₆ and vitamin B₁₂ intake and depression in the SUN cohort study