Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice

Shang, Qingsen; Song, Guanrui; Zhang, Meifang; Shi, Jingjing; Xu, Chen; Hao, Jiejie; Li, Guoyun; Yu, Guangli

doi:10.1016/j.jff.2016.11.002

Cited by 213 publications

(163 citation statements)

References 48 publications

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“…Previous studies indicated that diet‐induced obese mice would significantly elevate fasting glucose and insulin levels accompanied by an increased HOMA‐IR value . In the present study, SCSP and d‐SCSP treatments resulted in a significant reduction of fasting glucose and insulin levels along with a decrease in HOMA‐IR values ( Figure A–C, p < 0.05).…”

Section: Resultssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

“…Recently, a growing body of evidence has proven that the modulation of the gut microbiota by dietary functional food ingredients can ameliorate obesity and its complications, especially polysaccharides . For example, the intake of unabsorbed fucoidan from edible brown seaweeds reduced body weight, insulin resistance, and systematic inflammation in high‐fat diet (HFD)‐fed mice mainly by increasing the growth of specific beneficial bacteria in the gut . An essential mechanism for indigestible polysaccharides preventing diet‐induced obesity is that microbial fermentation generates SCFAs, which play a role in the regulation of energy balance, inflammatory processes, and obesity .…”

Section: Introductionmentioning

confidence: 99%

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Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhu

Sun

et al. 2018

Molecular Nutrition Food Res

142

119

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Scope Sulfated polysaccharide from sea cucumber (SCSP), Stichopus japonicus, has been shown to prevent diverse diseases, but little is known about its effects on obesity and gut microbiota in mice fed a high‐fat diet (HFD). Methods and results Diet‐induced obese, BALB/c mice are fed an HFD with or without SCSP and depolymerized SCSP (d‐SCSP, 0.004 kcal g−1) for 8 weeks. The results show that both SCSP and d‐SCSP reduce body weight, fat and liver hypertrophy, insulin resistance, and serum lipid and inflammatory cytokine levels in HFD‐fed mice. Moreover, SCSP and d‐SCSP not only prevent HFD‐induced gut disorder, as indicated by the enriched probiotic Akkermansia and reduce endotoxin‐bearing Proteobacteria, but also improve the SCFAs and endotoxin (LPS) levels and gut tissue index. Spearman's correlation analysis reveals that several specific genera are strongly correlated with obesity‐related indexes. In addition, the inhibitory effect of d‐SCSP on fat accumulation is more effective than that of SCSP, which may be related to their different regulation of the gut microbiota. Conclusions These findings suggest that SCSP can prevent diet‐induced obesity and its associated diseases by modulating the gut microbiota and improving microbial metabolites and gut tissue, and its effects can be enhanced by free‐radical depolymerization.

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Section: Resultssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhu

Sun

et al. 2018

Molecular Nutrition Food Res

142

119

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“…Figure (Okolie et al , ). The data that support the findings of this study are openly available in Web of Science at https://doi.org/10.1111/jfbc.12392 (Shang et al , ). The data that support the findings of this study are openly available in Web of Science at https://doi.org/10.1016/j.jff.2016.11.002.…”

Section: Data Availability Statementsupporting

confidence: 73%

“…Natural fucoidan has two types of chains, type I chain consists of α‐ (1 → 3)‐linked fucose and type II chain consists of altering α‐(1 → 3) and α (1 → 4)‐linked fucose (Cumashi et al , ). Molecular weight and sulphate content of fucoidan from Ascophyllum nodosum with type II chain were 1330 kDa and 21.0%, but MW and sulphate content of fucoidan from Laminaria japonica with type I chain were merely 310 kDa and 18.4% (Shang et al , ), respectively. The differences in the position of sulphate group of fucoidan with classical structures are shown in Fig.…”

Section: Fucoidanmentioning

confidence: 99%

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

You

Gong

et al. 2019

Int J of Food Sci Tech

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Summary The gut microbiota appears critical in the metabolic health and anti‐disease activity. In this review, we discuss three brown seaweed polysaccharides (alginate, laminarin, fucoidan) for their structural information, the digestive behaviour and the effects on gut microbiota. Bioactivities are associated with various physicochemical properties, like solubility, viscosity, hydration properties, molecular weight, monosaccharide composition, and so on. Brown seaweed polysaccharides can be completely utilised by microbes in the large bowel, and they can regulate the gut microbiota. The ultimate metabolite of these polysaccharides is mainly short‐chain fatty acids, which are able to regulate the ecology of the gut microbiota by increasing the growth of beneficial bacteria and inhibiting the growth of some harmful bacteria. In addition, this article also discusses the relationship between the structure and activity of modulating the gut microbiota. Results show that polysaccharides with low molecular weight are more conductive to modulate gut microbiota.

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Network pharmacology‐based investigation to explore the effect and mechanism of Erchen decoction against the nonalcoholic fatty liver disease

Liu

et al. 2021

The Anatomical Record

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This study aimed to uncover the potential mechanism of Erchen decoction (ECD) on the amelioration of nonalcoholic fatty liver disease (NAFLD). Network pharmacology and bioinformatics were used to determine the active components of ECD and its potential target in treating NAFLD. High fat diet (HFD)-induced NAFLD mice model was used. Liver tissues were stained with hematoxylin and eosin, and Oil Red O. Serum lipid profiles and hepatic inflammatory molecules in lipopolysaccharide (LPS)/Toll-like receptor-4 (TLR-4) pathway were confirmed by enzyme-linked immunosorbent assay. Intestinal barrier function, including intestinal epithelial tight junction (IETJ) proteins, fecal short-chain fatty acids (SCFAs) concentration and intestinal microbiota composition, was also assessed. Screening relevant databases revealed 123 active components and 158 potential target proteins in ECD, as well as 1,783 differential genes for NAFLD. Enrichment analyses predicted that the regulation of LPS, cholesterol metabolism and inflammatory pathways might be the underlying mechanisms of ECD in NAFLD treatment. ECD ameliorated the multi-profiles of NAFLD and reversed the high levels of inflammatory molecules such as, serum LPS, hepatic TLR-4, tumor necrosis factor-α, and interleukin-1β. Additionally, ECD upregulated the concentration levels of IETJ proteins and fecal SCFAs. 16s RNA sequencing indicated that ECD can improve the gut microbiota, such as Akkermansia, Clostridium XIVa, Coprococcus, and Ruminococcus. The current study demonstrated that ECD can reverse the HFD-induced intestinal barrier dysfunction, thereby reducing the LPS translocation and alleviating the hepatic inflammation, and eventually exhibiting a protective effect against NAFLD. 摘要本研究旨在揭示二陈汤 (ECD) 改善非酒精性脂肪肝 (NAFLD) 的潜在机制。利用网络药理学和生物信息学方法确定 ECD 的活性成分及其治疗 NAFLD 的潜在靶点。采用高脂饲料 (HFD) 诱导的 NAFLD 小鼠模型，以 HE 染色和油红染色对肝脏进行组织学观察；以酶联免疫吸附法检测血脂谱和肝脏炎症分子在脂多糖 (LPS) / Toll 样受体 4 (TLR-4) 通路中的表达；并以肠上皮紧密连接蛋白 (IETJ) 、粪便短链脂肪酸 (SCFAs) 浓度和肠道菌群来评价肠道屏障

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Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice

Cited by 213 publications

References 48 publications

Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

Network pharmacology‐based investigation to explore the effect and mechanism of Erchen decoction against the nonalcoholic fatty liver disease

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