Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat

Mauriz, José L.; Matilla, B.; Culebras, Jesús M.; González, Pablo; González‐Gallego, Javier

doi:10.1016/s0891-5849(01)00716-x

Cited by 81 publications

(62 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This effect may have implications for therapeutic developments in a variety of diseases, including asthma. In a rat model of haemorrhagic shock, a glycine-supplemented diet reduced oxidative stress and augmented anti-oxidant enzyme activities, while it also downregulated the expression of nuclear factor-kB and inducible nitric oxide synthetase [35], both of which are increased in the inflammation associated with asthma [9]. In humans with malnutrition, supplemental glycine leads to increased levels of the blood anti-oxidant glutathione [27].…”

Section: Discussionmentioning

confidence: 99%

Amino acids and asthma: a case-control study

Fogarty¹,

Broadfield²,

Lewis³

et al. 2004

Eur Respir J

View full text Add to dashboard Cite

Amino acids contribute to various anti-oxidant and immunological activities relevant to asthma pathogenesis, raising the possibility that differences in amino acids may be involved in asthma aetiology. The authors hypothesised that cystine reduces the risk of asthma via glutathione metabolism. Methionine, glutamine, glutamic acid and glycine may have potential protective effects, whilst arginine, phenylalanine and tryptophan may have adverse effects in asthma.Fasting plasma levels of amino acids were compared in a case-control study. A total of 89 adults, aged 18-65 yrs, with asthma controlled by inhaled corticosteroids, were recruited from a volunteer database and local primary care registers, and compared with 89 controls individually matched for age, sex and primary care centre.Contrary to the primary hypothesis, cases had higher fasting plasma cystine levels than controls, and there was no difference between cases and controls in any of the other amino acids tested, with the exception of plasma glycine, which was associated with a strongly reduced risk of asthma (odds ratio for the highest tertile compared to lowest 0.30 (95% confidence interval (0.11-0.82)).This study negates the hypothesis that higher fasting plasma cystine levels have a protective effect on the risk of asthma, although the inverse correlation with plasma glycine deserves further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Amino acids and asthma: a case-control study

Fogarty¹,

Broadfield²,

Lewis³

et al. 2004

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…129 Dietary glycine has been shown to inhibit the activation of NF-B and prevent hepatic injury in hemorrhagic shock in rats. 130 In another study on pentoxifylline, a methyl xanthine derivative, the effect on collagen induction and on the production of mRNA of IL-6 and TGF-1 in rat HSC cell line CFSC-2G exposed to acetaldehyde was investigated. Pentoxifylline was shown to exert a protective effect on hepatic fibrosis.…”

Section: Miscellaneous Inhibitorsmentioning

confidence: 99%

Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

Ali¹,

Mann²

2004

Cell Biochemistry & Function

139

View full text Add to dashboard Cite

Activation of transcription factors plays a pivotal role in many signal transduction pathways. Of particular interest is NF-kappaB, which is present in the cytoplasm in an inactive form, where it can be activated in response to many different stress conditions such as infection, inflammation, heat shock etc. It has also been associated with apoptosis and tissue repair. Modulation of signal transduction events that mediate activation of NF-kappaB seems to have a great potential in not only treating many disease conditions, but also in tissue repair. The present review article is an attempt to put together many different conditions where the NF-kappaB activation pathway appears to be crucial in transducing signals under stress conditions, and to explore the possibility of its modulation as a targeted treatment modality.

show abstract

“…26) In conclusion, curcumin improved the LV function in pressure overloaded rabbits, and this effect may result from the inhibition of myocardiac collagen remodeling associated with suppression of overexpression of TNF-a and MMP-2.…”

Section: Curcumin Ameliorates the LV Function In Rabbits With Pressurmentioning

confidence: 82%

Curcumin Ameliorates Left Ventricular Function in Rabbits with Pressure Overload: Inhibition of the Remodeling of the Left Ventricular Collagen Network Associated with Suppression of Myocardial Tumor Necrosis Factor-.ALPHA. and Matrix Metalloproteinase-2 Expression

Yao

Wang

Cui

et al. 2004

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Ventricular remodeling is a milestone in the progression of congestive heart failure (CHF), which is characterized by cardiomyocyte hypertrophy, apoptosis, and remodeling of the extracellular matrix (ECM). During cardiac hypertrophy transition to heart failure, the composition and types of collagen undergo complex alterations due to neurohormonal disturbance and local cytokine release. CHF is a process of systemic inflammation with overexpression of local inflammatory cytokines including tumor necrosis factor (TNF)-a, interleukin-1 (IL-1) b and matrix metalloproteinases (MMPs). Those inflammatory cytokines may play a crucial role in the development of heart failure. 1)Recent clinical trials and experimental studies have provided evidence to suggest that increased cardiac TNF-a expression contributes to the progress of left ventricle (LV) dysfunction.2,3) Experimental studies showed that increased TNF-a levels could cause LV remodeling and promote the deterioration of LV function. 4,5) MMPs constitute a family of zinc-dependent enzymes that are responsible for ECM degradation in either a physiological or pathological process.6) Myocardial ECM remodeling regulated by MMPs is implicated in the progression of heart failure. Recent reports have shown TNF-a contributes to the process of myocardial remodeling in evolving heart failure through the local induction of specific MMPs. [5][6][7][8] Modification of the expression of TNF-a and MMPs may serve as potential therapeutic targets in the treatment of heart failure.Curcumin is a polyphenol contained in the rhizome of the plant Curcuma longa Linn. Previous studies demonstrated that curcumin is an effective cell protector with antiinflammatory, antioxidizant and antifibrotic effects. It can inhibit the expression of a sequence of inflammatory cytokines such as TNF-a, IL-1, or IL-8 9) and MMP-3, MMP-13, 10) MMP-2 11) in the kidney or derma. Curcumin is a potential cleanser of oxidized free radicals (OFRs) and this effect is much stronger than that of carotene or vitamin E 12) due to its ability to suppress the synthesis of xanthine oxidase and lower its activity, 13) but to enhance the activity of the superoxide dismutase (SOD) enzyme.14) Curcumin can retard the fibrotic process in the lung, 15) liver, or kidney.16) It is proposed that this effect is associated with down-regulation of TNF-a expression, reducing lipid peroxidization and blocking the transmission of apoptotic signals.16) Curcumin suppresses renal parenchymal cell apoptosis in mice in which the lateral ureter was ligated to inhibit activation of nuclear transcription factor (NF)-kB and down-regulate the expression of Fas-ligand.In the present study, we tested the hypothesis that curcumin could improve cardiac function and counteract myocardiac collagen remodeling of failing hearts. We also explored the influence of curcumin on the expression of TNF-a and MMP-2 in the LV myocardium of pressure overloaded rabbits. Objective: Curcumin is a wide-spectrum cellular protector with antiinflammatory, antioxidizant, ...

show abstract

Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat

Cited by 81 publications

References 44 publications

Amino acids and asthma: a case-control study

Amino acids and asthma: a case-control study

Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

Curcumin Ameliorates Left Ventricular Function in Rabbits with Pressure Overload: Inhibition of the Remodeling of the Left Ventricular Collagen Network Associated with Suppression of Myocardial Tumor Necrosis Factor-.ALPHA. and Matrix Metalloproteinase-2 Expression

Contact Info

Product

Resources

About